枸橼酸咖啡因在早产儿呼吸机辅助通气中的临床效果

林建丰 庄泽吟 陈淑特

[摘要]目的 探讨枸橼酸咖啡因在早产儿呼吸机辅助通气中的临床效果。方法 选取2017年11月～2019年2月我院新生儿重症监护室收治的81例需要呼吸机辅助通气的早产儿作为研究对象，采用随机数字表法将其分为观察组（37例）与对照组（44例）。观察组采用枸橼酸咖啡因治疗，对照组采用氨茶碱治疗。比较两组的临床相关指标、撤机失败率及并发症发生情况。结果 观察组的有创通气时间与住院时间短于对照组，住院费用低于对照组，出院时体重增长量多于对照组，差异有统计学意义（P<0.05）。两组的无创辅助通气时间比较，差异无统计学意义（P>0.05）。兩组的撤机失败率比较，差异无统计学意义（P>0.05）。两组的烦躁、心率增快、血糖升高、消化系统症状、支气管肺发育不良发生率比较，差异无统计学意义（P>0.05）。结论 呼吸机辅助通气的早产儿早期联合使用枸橼酸咖啡因治疗，能有效缩短有创机械辅助通气时间，降低撤机失败率，缩短住院时间，减少住院费用，但在无创呼吸机辅助通气中，氨茶碱的疗效与枸橼酸咖啡因相当，两者的并发症发生率差别不明显。

[关键词]咖啡因;氨茶碱;通气机;机械;婴儿;早产

[中图分类号] R969.4          [文献标识码] A          [文章编号] 1674-4721（2019）12（b）-0159-04

Clinical effect of Caffeine Citrate in ventilator assisted treatment of premature infants

LIN Jian-feng   ZHUANG Ze-yin   CHEN Shu-te

Department of Neonatology， Pengpai Memorial Hospital Affiliated to Guangdong Medical University in Haifeng County， Guangdong Province， Haifeng   516400， China

[Abstract] Objective To investigate the clinical effect of Caffeine Citrate in ventilator assisted treatment of premature infants. Methods A total of 81 premature infants requiring ventilator assisted ventilation admitted to the Neonatal Intensive Care Unit in our hospital from November 2017 to February 2019 were selected as study subjects， they were divided into the observation group （37 cases） and the control group （44 cases） by the random number table method. The observation group was treated with Caffeine Citrate， while the control group was treated with Aminophylline. The clinical relevant indicators， weaning failure rate and incidence of complication were compared between the two groups. Results The duration of invasive ventilation and the length of hospitalization in the observation group were shorter than those in the control group， the cost of hospitalization was lower than that in the control group， and the weight gain at discharge was more than that in the control group， with statistically significant differences （P<0.05）. There was no significant difference in the duration of non-invasive assisted ventilation between the two groups （P>0.05）. There was no significant difference in the weaning failure rate between the two groups （P>0.05）. There were no significant differences in irritability， increased heart rate， elevated blood sugar， digestive symptoms， and incidence of bronchopulmonary dysplasia between the two groups （P>0.05）. Conclusion For premature infants who are treated with mechanical ventilation， the use of Caffeine Citrate can effectively reduce the duration of invasive mechanical ventilation， failure rate of ventilator removal， the length and cost of hospitalization， but in the treatment of noninvasive mechanical ventilation， the treatment effect of Aminophylline is equivalent to Caffeine Ciatrate， there is no statistically significant difference in the incidence of complication between the two groups.