基于数据挖掘的现代湖湘男科流派医家治疗激素难治性前列腺癌用药规律研究

刘德果 赵姣 苏艺峰 陈其华 胡金辉 向时竹 林梦姣

〔摘要〕 目的 基于數据挖掘研究现代湖湘男科流派代表医家谭新华、贺菊乔、陈其华治疗激素难治性前列腺癌（hormone refractory prostate cancer， HRPC）的用药规律。方法 收集2012年5月至2020年8月现代湖湘男科流派医家谭新华、贺菊乔、陈其华于湖南中医药大学第一附属医院国医堂专家门诊治疗HRPC的处方，采用中医传承辅助平台软件（V 2.50）对上述处方进行描述性分析、关联规则分析、复杂系统熵聚类分析。结果 本研究共纳入HRPC治疗处方241首，涉及药物99味，频次>100次的药物共14味，前5位依次为黄芪、甘草、三棱、莪术、熟地黄。药物四气前3位分别为温、寒、平;药物五味前3位分别为甘、辛、苦;药物归经前3位分别为肾、脾、肝。获得治疗HRPC药物组合28条;经复杂系统熵聚类分析后，获得7个核心药对及4个新药物组合。结论 “肾虚血瘀”是HRPC发病的主要病机，现代湖湘男科流派医家治疗HRPC遣方用药侧重于益肾温阳，活血化瘀，可为中医临床治疗HRPC提供用药参考。

〔关键词〕 前列腺癌;激素难治性前列腺癌;数据挖掘;用药规律;男科;医家

〔中图分类号〕R277.5       〔文献标志码〕A       〔文章编号〕doi：10.3969/j.issn.1674-070X.2021.05.014

Research on the Drug Rule of Modern Huxiang Andrology School in the Treatment of

Hormone-refractory Prostate Cancer Based on Data Mining

LIU Deguo1，2， ZHAO Jiao1， SU Yifeng1， CHEN Qihua2*， HU Jinhui2， XIANG Shizhu1， LIN Mengjiao1

（1. Hunan University of Chinese Medicine， Changsha， Hunan 410008， China; 2. The First Affiliated Hospital of Hunan University of Chinese Medicine， Changsha， Hunan 410208， China）

〔Abstract〕 Objective Based on data mining to study the medication rules of modern Huxiang andrology school representatives Tan Xinhua， He Juqiao， Chen Qihua， etc. in the treatment of hormone refractory prostate cancer （HRPC）. Methods From May 2012 to August 2020， doctors Tan Xinhua， He Juqiao， and Chen Qihua from the modern Huxiang andrology school were collected from the expert clinic of the Traditional Chinese Medicine Hall of the First Affiliated Hospital of Hunan University of Chinese Medicine. The prescriptions for HRPC were collected， and the traditional Chinese medicine inheritance auxiliary platform software （V 2.50） was used to perform descriptive analysis， association rule analysis， and complex system entropy cluster analysis on the above prescriptions. Results A total of 241 prescriptions for HRPC were included in this study， involving 99 drugs， and 14 drugs with a frequency of more than 100 times. The top 5 were Huangqi （Astragali Radix）， Gancao （Glycyrrhizae Radix Et Rhizoma）， Sanleng （Sparganii Rhizoma）， Ezhu （Curcumae Rhizoma）， Shudihuang （Rehmanniae Radix Praeparata）. The top 3 of the four Qi of the drug were warm， cold， and flat; the top 3 of the five flavors of the drug were sweet， pungent， and bitter; the top 3 of the channels of the drug were kidney， spleen， and liver. 28 drug combinations for the treatment of HRPC were obtained through the association rule analysis; after complex system entropy cluster analysis， 7 core drug pairs and 4 new drug combinations were obtained. Conclusion "Kidney deficiency and blood stasis" is the main pathogenesis of the onset of HRPC. Modern Huxiang andrology school doctors used medicines to treat HRPC with a focus on invigorating the kidney and warming Yang， promoting blood circulation and removing blood stasis drugs， which can provide a reference for the clinical treatment of HRPC in traditional Chinese medicine.