乐映川
【摘要】 目的:探討输尿管镜下钬激光碎石术对输尿管结石患者术后康复及结石排净率的影响。方法:选取2018年2月-2019年7月笔者所在医院收治的输尿管结石患者115例,依照奇偶顺序分为研究组(58例)、对照组(57例)。对照组采用输尿管镜气压弹道碎石术治疗,研究组采用输尿管镜下钬激光碎石术治疗。比较两组手术指标(手术时间、术后血尿持续时间、住院时间)、结石排净率、并发症发生率、应激指标(血清皮质醇、丙二醛水平)。结果:研究组结石排净率为96.55%,高于对照组的75.44%,差异有统计学意义(P<0.05);研究组手术时间、术后血尿持续时间、住院时间均短于对照组,差异均有统计学意义(P<0.05);术后10 min研究组血清皮质醇、丙二醛水平均低于对照组,差异均有统计学意义(P<0.05);研究组术后并发症发生率为3.45%,低于对照组的17.54%,差异有统计学意义(P<0.05)。结论:输尿管结石患者采用输尿管镜下钬激光碎石术治疗,能缩短手术时间,清除结石,减轻应激反应,促进患者早期康复,安全性高。
【关键词】 输尿管镜 钬激光碎石术 输尿管结石
doi:10.14033/j.cnki.cfmr.2020.15.010 文献标识码 B 文章编号 1674-6805(2020)15-00-03
Effect of Holmium Laser Lithotripsy under Ureteroscope on Postoperative Recovery and Stone Removal Rate of Patients with Ureteral Calculi/LE Yingchuan. //Chinese and Foreign Medical Research, 2020, 18(15): -26
[Abstract] Objective: To investigate the effect of holmium laser lithotripsy under ureteroscope on postoperative recovery and stone removal rate of patients with ureteral calculi. Method: From February 2018 to July 2019, 115 patients with ureteral calculi in our hospital were selected and divided into the study group (58 cases) and the control group (57 cases) according to parity order. The control group was treated with ureteroscopy pneumatic lithotripsy, while the study group was treated with ureteroscopy holmium laser lithotripsy. The surgical indexes (duration of operation, duration of postoperative hematuria, length of hospital stay), stone removal rate, incidence of complications, and stress indexes (serum cortisol and malondialdehyde levels) of two groups were compared. Result: The stone removal rate of the study group was 96.55%, higher than that of the control group (75.44%), the difference was statistically significant (P<0.05). All the operative time, postoperative hematuria duration time and hospital stay time in the study group were shorter than those in the control group, the differences were statistically significant (P<0.05). At 10 minutes after operation, the serum cortisol and malondialdehyde levels in the study group were lower than those in the control group, the differences were statistically significant (P<0.05). The incidence of postoperative complications in the study group was 3.45%, lower than that in the control group (17.54%), the difference was statistically significant (P<0.05). Conclusion: Holmium laser lithotripsy under ureteroscope can shorten the operation time, clear the calculi, reduce the stress response, promote the early recovery of patients with ureteral calculi, with high safety.
皮质醇、丙二醛水平是临床反映应激反应常见生化指标,其水平越高表明机体应激损伤程度越高[12]。本研究显示,术后10 min研究组血清皮质醇、丙二醛水平均低于对照组(P<0.05),表明输尿管结石患者采用输尿管镜下钬激光碎石术治疗,能减轻应激反应。此外,输尿管镜下钬激光碎石术对术者专业技术要求较高,其应熟练掌握输尿管镜及钬激光操作技巧,动作轻柔,以减少对输尿管及其他组织损失,保证手术效果;同时在采用输尿管镜查探管腔时,若出现视野受限,未能完全看清整个管腔时,应退出输尿管镜,适当调整角度,再继续前进查探病灶情况;操作时应确保降低膀胱内压,充分麻醉,以防出现输尿管抱镜现象,输尿管退镜困难,导致发生输尿管损伤。
综上可知,输尿管结石患者采用输尿管镜下钬激光碎石术治疗,能缩短手术时间,清除结石,减轻应激反应,促进患者早期康复,安全性高。
参考文献
[1]王正权,陶沙,黄小七,等.输尿管开口电切术联合输尿管镜治疗输尿管结石16例[J].安徽医药,2019,23(5):923-925.
[2]孙永凯.输尿管镜气压弹道碎石术治疗输尿管结石的临床分析[J].中国冶金工业医学杂志,2019,36(3):322-323.
[3]袁顺辉,杨德林,李志鹏,等.筋膜扩张器协助输尿管镜钬激光治疗婴幼儿中下段输尿管结石的疗效观察[J].中国内镜杂志,2018,24(1):93-95.
[4]王健宇,胡宗阳,陶朝发,等.经尿道输尿管镜下钬激光碎石术治疗输尿管结石的临床疗效观察[J].局解手术学杂志,2018,27(1):44-46.
[5]王洪兵,李康慧,平峰.三金片联合ESWL治疗输尿管结石(湿热蕴结)的临床研究[J].中华中医药学刊,2019,37(6):1417-1420.
[6]姚增民,白志杰,王新胜,等.NMSCT输尿管重建联合肾血流图诊断输尿管结石[J].中国中西医结合外科杂志,2019,25(2):179-182.
[7]许清江,叶烈夫,朱庆国,等.输尿管壁厚度对嵌顿性输尿管结石的预测价值[J].中华泌尿外科杂志,2019,40(3):210-214.
[8]储传敏,杨炜,杨启维,等.镍钛合金泌尿系统取石网在输尿管镜碎石术中的临床应用[J].中华航海医学与高气压医学杂志,2017,24(4):315-318.
[9]杨钟良,黄毅.输尿管镜下钬激光碎石与气压弹道碎石术治疗输尿管结石的疗效比较[J].解放军预防医学杂志,2019,37(5):71-72.
[10]高永涛,闫波,高恩江.自拟三金排石汤辅助输尿管软镜下钬激光碎石术治疗肾结石临床疗效分析[J].山西医药杂志,2018,47(6):673-674.
[11]顧日辉,刘丽芳.经皮肾镜结合输尿管软镜钬激光碎石术治疗复杂性肾结石的疗效分析[J].首都食品与医药,2019,26(24):19-20.
[12]梁苏东,吕高飞,阮亚石,等.输尿管软镜碎石术与经皮肾镜碎石术对肾结石患者炎性因子、氧化应激及应激激素水平的影响[J].海南医学院学报,2017,23(20):2783-2786.
(收稿日期:2020-01-17) (本文编辑:马竹君)