吴夕华
[摘要] 目的 探析缩宫素联合卡贝缩宫素在高危产妇剖宫产术中的应用效果。方法 简单随机选取2017年1月—2018年6月在该院进行剖宫产术的100例高危产妇进行分组研究,随机分为对照组(n=50)与治疗组(n=50)。对照组给予缩宫素治疗,治疗组给予缩宫素联合卡贝缩宫素治疗,对两组临床疗效、产时出血量、产后24 h出血量及不良反应发生率进行统计比较。结果 治疗组临床有效率为96.00%,对照组为84.00%,治疗组显著高于对照组(χ2=4.350,P<0.05)。治疗组产时出血量、产后24 h出血量分别为(248.46±45.24)mL、(400.80±57.02)mL,对照组分别为(313.02±48.78)mL、(476.13±57.15)mL,治疗组显著低于对照组(t=5.180、6.040,P<0.05)。治疗组不良反应发生率为8.00%,对照组为6.00%,组间差异无统计学意义(χ2=0.340,P>0.05)。结论 高危产妇剖宫产术中应用缩宫素联合卡贝缩宫素的临床效果更加确切,可进一步降低产后出血量,且不会明显增加不良反应,具有安全、可靠的特点。
[关键词] 高危产妇;剖宫产术;缩宫素;卡贝缩宫素;临床疗效
[中图分类号] R719 [文献标识码] A [文章编号] 1674-0742(2020)06(b)-0103-03
[Abstract] Objective To explore the effect of oxytocin combined with carbetocin in high-risk cesarean section. Methods From January 2017 to June 2018, 100 high-risk women undergoing cesarean section in the hospital were easy randomly divided into a control group (n=50) and a treatment group (n=50). The control group was given oxytocin, and the treatment group was given oxytocin combined with carbetocin. The clinical efficacy, blood loss at birth, blood loss at 24 h postpartum and the incidence of adverse reactions were statistically compared between the two groups. Results The clinical effective rate was 96.00% in the treatment group and 84.00% in the control group. The treatment group was significantly higher than the control group (χ2=4.350, P<0.05). Bleeding volume at delivery and 24 h postpartum in the treatment group were (248.46±45.24) mL, (400.80±57.02) mL, and the control group were (313.02±48.78) mL and (476.13±57.15) mL, respectively, lower than the control group (t=5.180, 6.040, P<0.05). The incidence of adverse reactions in the treatment group was 8.00%, and that in the control group was 6.00%. The data was not statistically significantly different (χ2=0.340, P>0.05). Conclusion The clinical effect of oxytocin combined with carbetocin in cesarean section of high-risk women is more accurate, it can further reduce the amount of postpartum hemorrhage, and it will not significantly increase adverse reactions, being safe and reliable.
[Key words] High-risk parturient; Cesarean section; Oxytocin; Carbetocin; Clinical efficacy; Postpartum hemorrhage
產后出血、宫缩乏力是产妇生产中较为常见的情况,尤其是剖宫产术中与术后的大出血,是引起产妇病死的关键因素。根据有关调查显示,在剖宫产术治疗中,产后出血发生率约为2%~3%,随着剖宫产术的不断普及,产后出血发生率越来越高,其原因主要为宫缩乏力[1]。近些年来,尽管剖宫产术技术越来越完善,但产后出血防范效果并不理想。缩宫素是促进宫缩的一线药物,但对部分产妇效果并不理想,需与其他促进宫缩的药物联合使用,从而进一步预防产后出血。卡贝缩宫素是一种用于治疗宫缩乏力与产后出血的新型催产类药物,临床效果显著。为此,该文简单随机选取2017年1月—2018年6月在该院进行剖宫产术的100例高危产妇进行分组研究,探讨缩宫素联合卡贝缩宫素的应用效果,现报道如下。
综上所述,高危产妇剖宫产术中应用缩宫素联合卡贝缩宫素的临床效果更加确切,可进一步降低产后出血量,且不会明显增加不良反应,具有安全、可靠的特点。
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(收稿日期:2020-03-15)