关节腔内注射玻璃酸钠治疗类风湿关节炎的疗效观察

周燕莉 王焰

【摘要】 目的 探討类风湿关节炎应用关节腔内注射治疗的临床效果。方法 100例类风湿关节炎患者， 随机分为关节腔内注射治疗组和常规治疗组， 每组50例。常规治疗组给予甲氨蝶呤治疗， 关节腔内注射治疗组在常规治疗组基础上给予关节腔内注射玻璃酸钠治疗。观察比较两组治疗前后关节视觉模拟评分、晨僵维持时间、肿胀程度评分、C反应蛋白、血沉、疼痛症状消失时间、疼痛症状缓解时间以及不良反应发生情况。结果 治疗后， 关节腔内注射治疗组关节视觉模拟评分（1.24±0.15）分、晨僵维持时间（1.24±0.12）h、肿胀程度（5.53±1.01）分、C反应蛋白（10.19±2.36）μg/L、血沉（34.56±3.26）mm/h均低于常规治疗组的（3.24±1.34）分、（1.78±0.61）h、（6.56±1.42）分、（14.11±4.12）μg/L、（45.72±12.11）mm/h， 差异具有统计学意义（P<0.05）;关节腔内注射治疗组疼痛症状消失时间、疼痛症状缓解时间分别为（42.12±3.57）、（12.12±3.21）d， 明显短于常规治疗组的（57.57±3.89）、（18.57±3.24）d， 差异有统计学意义（P<0.05）。两组不良反应发生率比较， 差异无统计学意义（P>0.05）。结论 类风湿关节炎患者实施关节腔内注射玻璃酸钠治疗可获得较好效果。

【关键词】 类风湿关节炎;关节腔内注射;玻璃酸钠

DOI：10.14163/j.cnki.11-5547/r.2019.29.037

【Abstract】 Objective   To discuss the clinical effect of intra-articular injection of sodium hyaluronate for the treatment of rheumatoid arthritis. Methods   A total of 100 rheumatoid arthritis patients were randomly divided into intra-articular injection group and conventional treatment group， with 50 cases in each group. The conventional treatment group received methotrexate for treatment， and the intra-articular injection group received intra-articular injection of sodium hyaluronate on the basis of the conventional treatment group. Observation and comparison were made on visual analogue score of joint， duration of morning stiffness， degree of swelling， C-reactive protein， erythrocyte sedimentation rate before and after treatment， disappearance time of pain symptoms， remission time of pain symptoms and occurrence of adverse reactions between the two groups. Results   After treatment， the visual analogue score of joint （1.24±0.15） points， duration of morning stiffness （1.24±0.12） h， duration of morning stiffness （5.53±1.01） points， C-reactive protein （10.19±2.36） μg/L and erythrocyte sedimentation rate （34.56±3.26） mm/h in the intra-articular injection group were lower than （3.24±1.34） points， （1.78±0.61） h， （6.56±1.42） points， （14.11±4.12） μg/L and （45.72±12.11） mm/h in the conventional treatment group. Their difference was statistically significant （P<0.05）. The disappearance time of pain symptoms and remission time of pain symptoms respectively as （42.12±3.57） and （12.12±3.21） d in the intra-articular injection group， and that were obviously shorter than （57.57±3.89） and （18.57±3.24） d in conventional treatment group. Their difference was statistically significant （P<0.05）. There was no statistically significant difference in incidence of adverse reactions between the two groups （P>0.05）. Conclusion   Intra-articular injection of sodium hyaluronate in rheumatoid arthritis patients can achieve better results.