芪棱汤联合阿替普酶静脉溶栓对急性脑梗死患者血清炎性因子和神经功能康复的影响

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【摘要】 目的：探讨芪棱汤联合阿替普酶静脉溶栓对急性脑梗死患者血清炎性因子和神经功能康复的影响。方法：回顾性分析2014年10月-2016年10月本院溶栓治疗的116例急性脑梗死患者临床资料，按照治疗方案不同将其分为试验组和对照组，各58例。对照组患者给予常规治疗和阿替普酶静脉溶栓治疗，试验组在对照组基础上加用了芪棱汤进行溶栓治疗。采用美国国立卫生研究院卒中量表（NIHSS）评估两组患者溶栓前后神经功能康复情况；采用Barthel指数评价两组患者溶栓前后日常生活能力情况；对比分析两组患者溶栓前后血清超敏C-反应蛋白（hs-CRP）、肿瘤坏死因子α（TNF-α）、白介素-6（IL-6）水平。结果：溶栓后24 h，试验组患者Barthel指数明显高于对照组，而NIHSS评分明显低于对照组，差异均有统计学意义（P<0.05），溶栓后7 d，试验组患者Barthel 指数进一步高于对照组，而NIHSS评分也进一步较对照组降低，差异均有统计学意义（P<0.05）；溶栓后24 h、7 d，试验组患者

hs-CRP、TNF-α及IL-6水平均明显低于对照组，差异均有统计學意义（P<0.05）；试验组基本治愈率明显高于对照组，差异有统计学意义（P<0.05），而总有效也明显高于对照组，差异有统计学意义（P<0.05）。结论：芪棱汤联合阿替普酶静脉溶栓治疗能明显改善急性脑梗死患者神经功能缺损程度，提高患者日常生活能力及能显著降低患者炎性因子水平。

【关键词】 芪棱汤； 阿替普酶； 溶栓； 急性脑梗死； 血清炎性因； 神经功能康复

Effect of Stilbene Rib Soup Combined with Atenolol Enzyme on Serum Inflammatory Factors and Neural Function Recovery in Patients with Acute Cerebral Infarction/LI Min，LIAO Le-le，TANG Gan-yi，et al.//Medical Innovation of China，2017，14（11）：020-024

【Abstract】 Objective：To observe the effect of Stilbene Rib Soup combined with Atenolol Enzyme on serum inflammatory factors and neural function recovery in patients with acute cerebral infarction.Method：From October 2014 to October 2016，116 acute cerebral infarction patients were divided into the control group and the experimental group according to the different treatment method.The control group was given routine therapy and Atenolol Enzyme intravenous thrombolysis treatment，the experimental group on the basis of the control group was given Stilbene Rib Soup.Neural function recovery of two groups before and after thrombolysis were evaluated by the national institutes of health stroke scale（NIHSS）.Daily life ability of two groups before and after thrombolysis were evaluated by Barthel index.Serum hypersensitive C-reactive protein（hs-CRP），tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6） of two groups before and after thrombolysis were compared.Result：The Barthel index of the experimental group were higher than those of the control group 24 h and 7 d after thrombolysis，NIHSS scores of the experimental group were lower than those of the control group，the differences had statistical significance（P<0.05）.Hs-CRP，TNF-α and IL-6 levels of the experimental group were lower than those of the control group 24 h and 7 d after thrombolysis，the differences had statistical significance（P<0.05）.Basic cure rate of the experimental group was higher than that of the control group，the difference had statistical significance（P<0.05）.The total effective of the experimental group was higher than that of the control group，the difference had statistical significance（P<0.05）.Conclusion：Stilbene Rib Soup combined Atenolol Enzyme can significantly improve the degree of nervous functional defects and daily life ability and can significantly decrease levels of serum inflammatory factors in patients with acute cerebral infarction.