Efficacy of the method of tonifying Qi, resolving phlegm and eliminating stasis in thetreatment of AECOPD: A meta analysis

Lu Zhang, Qin-Jun Yang, Xiang-Li Tong, JieZhu, Ze-Geng Li3✉

1. Anhui University of Chinese Medicine

2. The First Affiliated Hospital of Anhui University of Chinese Medicine

3. Institute of TCM Respiratory Disease Prevention and Control Anhui Academy of Chinese Medicine

ARTICLE INFO

Article history:Received 20 May 2022 Received in revised form 28 May 2022 Accepted 5 Jun 2022 Available online 14 Jun 2022

Keywords:Tonifying qi Resolving phlegm Eliminating stasis Chronic obstructive pulmonary diseases Acute exacerbation Meta-analysis

ABSTRACT Objective: To systematically evaluate the efficacy and safety of the method of tonifying qi,resolving phlegm and eliminating stasis in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods: Search the China Knowledge Network (CNKI),VIP Chinese Science and Technology Journal Database (VIP), Wanfang Data Knowledge Service Platform, China Biomedical Literature Database (CBM), PubMed, Embase, Cochrane Library, and select the databases that meet the requirements for tonifying qi, resolving phlegm and eliminating stasis. The stasis method in the treatment of AECOPD was included in the standard literature, and RevMan 5.4 software was used for statistical analysis. Results:A total of 10 articles were included, with a total of 854 patients, 435 in the treatment group and 419 in the control group. Systematic analysis shows that the method of tonifying qi, resolving phlegm and eliminating stasis combined with conventional Western medicine treatment of AECOPD is significantly different in total clinical effective rate than conventional Western medicine treatment alone [OR=3.98,95%CI(2.23,7.11), P＜0.00001];In terms of lung function,FEV1/FVC[MD=6.08,95%CI(5.01,7.15), P＜0.00001], FEV1[ MD=0.07,95%CI(0.01，0.13),P=0.02], FEV1%[MD=4.56,95%CI(3.09,6.02),P＜0.00001] is significantly higher than the control group; arterial oxygen partial pressure (PaO2)[MD=18.47,95%CI(16.77,20.16),P＜0.00001]Significant improvement compared to the control group; arterial partial pressure of carbon dioxide (PaCO2) [MD=-7.48,95%CI(-8.7,-6.26), P＜0.00001] was significantly lower than the control group. Conclusion: The current evidence shows that the method of tonifying qi, resolving phlegm and eliminating stasis combined with conventional Western medicine treatment of chronic obstructive pulmonary disease in acute exacerbations can improve clinical efficacy and improve the quality of life of patients.