缬沙坦联合氨氯地平治疗老年原发高血压合并糖尿病疗效观察

徐炳君

[摘要] 目的 观察缬沙坦联合氨氯地平治疗老年原发高血压合并糖尿病疗效。方法 以该院2018年1月—2019年7月间收治的老年原发高血压合并糖尿病患者中选取104例作为实验案例均分两组，参照组52例患者接受氨氯地平药物治疗，研讨组52例患者接受氨氯地平联合缬沙坦治疗，观察疾病疗效。 结果 治疗后研讨组2项血压及2项血糖指标相对于参照组有更明显的下降，同时研讨组治疗总体有效性90.38%，参照组治疗总体有效性63.46%，研讨组疗效优于参照组，组间比较差异有统计学意义（P<0.05）。结论 缬沙坦联合氨氯地平治疗老年原发高血压合并糖尿病疗效甚佳，能够改善患者血压及血糖水平。

[关键词] 缬沙坦;氨氯地平;老年原发高血压;糖尿病;疗效观察

[中图分类号] R4          [文献标识码] A          [文章编号] 1672-4062（2020）05（b）-0014-03

Observation on the Efficacy of Valsartan Combined with Amlodipine in the Treatment of Elderly Hypertension with Diabetes

XU Bing-jun

Department of Emergency Medicine， Junan County Traditional Chinese Medicine Hospital， Junan， Shandong Province， 276600 China

[Abstract] Objective To observe the efficacy of valsartan combined with amlodipine in the treatment of senile essential hypertension with diabetes. Methods A total of 104 elderly patients with primary hypertension and diabetes treated in the hospital from January 2018 to July 2019 were selected as experimental cases and divided into 2 groups. 52 patients in the reference group received amlodipine drug treatment， and the study group of 52 patients received amlodipine combined with valsartan to observe the effect of the disease. Results After treatment， the two blood pressure and two blood glucose indexes of the study group decreased more significantly than the reference group. At the same time， the overall effectiveness of the treatment group was 90.38%， and the overall effectiveness of the reference group was 63.46%. The treatment group was better than the reference group. There were statistically significant differences between groups（P<0.05）. Conclusion Valsartan combined with amlodipine is effective in treating elderly patients with hypertension and diabetes. It can improve patients' blood pressure and blood glucose levels.

[Key words] Valsartan; Amlodipine; Elderly hypertension; Diabetes; Efficacy observation

高血压是临床一种典型的慢性心血管疾病，是引发患者心脏病、肾衰竭、中风、血管瘤等诸多疾病的诱因[1]。老年群体是高血压的高发人群，发生率达到49.7%以上，主要是由于老年人身体免疫力、抵抗力下降，往往易合并糖尿病[2]。对于老年原发高血压合并糖尿病的治疗关键点在于胰岛素抵抗，这是因胰岛素与患者预后恢复关系密切[3]。临床治疗常采取联合用药方式，并遵循提高药效、减轻药物副反应、改善代谢综合征、保护靶器官为原则[4]。该文围绕该院于2018年1月—2019年7月收治的104例老年原发高血压合并糖尿病患者分组采用氨氯地平与其联合缬沙坦治疗，观察其治疗效果，现报道如下。

1  资料与方法

1.1  一般资料

以该院收治的老年原发高血压合并糖尿病患者中选取104例作为实验案例均分两组，参照组52例患者接受氨氯地平药物治疗，研讨组52例患者接受氨氯地平联合缬沙坦治疗，观察疾病疗效。纳入标准：符合中华医学会制定的原发高血压合并糖尿病相关诊断标准，患者年龄于60岁以上，对于該研究内容知晓，患者及其亲属自愿签署知情同意书。排除标准：合并肝、肾脏器功能衰竭或障碍等患者，治疗依从性差，难以配合治疗开展的患者。