血清胱抑素C与血清25羟维生素D对诊断儿童过敏性紫癜早期肾损害的临床价值

李飞 洪春香

[摘要] 目的 探討血清胱抑素C与血清25羟维生素D对诊断儿童过敏性紫癜早期肾损害的临床价值。 方法 选取2018年5月～2019年5月我院儿童过敏性紫癜患儿60例，根据肾功能结果分为无肾损害组和有肾损害组，每组30例，同期采用随机数字法收集我院儿保科进行健康体检的健康儿童30例作为对照组，比较三组尿mALB、血清CysC、25-（OH）vitD水平及其阳性情况。 结果 有肾损害组、无肾损害组尿mALB、血清CysC水平均显著高于对照组（P<0.05），血清25-（OH）vitD水平均显著低于对照组（P<0.05），有肾损害组尿mALB、血清CysC水平均显著高于无肾损害组（P<0.05），血清25-（OH）vitD水平显著低于无肾损害组（P<0.05）。有肾损害组尿mALB、血清CysC、25-（OH）vitD阳性率分别为33.3%（10/30）、26.7%（8/30）、30.0%（9/30），无肾损害组尿mALB、血清CysC、25-（OH）vitD阳性率分别为13.3%（4/30）、13.3%（4/30）、13.3%（4/30），对照组尿mALB、血清CysC、25-（OH）vitD阳性率分别为0、3.3%（1/30）、3.3%（1/30）。有肾损害组、无肾损害组尿mALB、血清CysC、25-（OH）vitD阳性率均显著高于对照组（P<0.05），而有肾损害组患儿的尿mALB、血清CysC、25-（OH）vitD阳性率均显著高于无肾损害组（P<0.05）。 结论 血清胱抑素C与血清25羟维生素D可用于诊断儿童过敏性紫癜早期肾损害，临床价值高。

[关键词] 血清胱抑素C;血清25羟维生素D;儿童过敏性紫癜;早期肾损害

[中图分类号] R446.6          [文献标识码] A          [文章编号] 1673-9701（2019）33-0012-03

[Abstract] Objective To explore the clinical value of serum cystatin C and serum 25-hydroxyvitamin D in the diagnosis of early renal damage in children with Henoch-Schonlein purpura. Methods 60 children with Henoch-Schonlein purpura from May 2018 to May 2019 in our hospital were randomLy enrolled and divided into the group of no renal and the group of renal damage according to renal function results， 30 cases in each group. 30 case healthy children receiving healthy checkup in the same period in department of children's health prevention in our hospital were selected as controls by random number method. The levels of urine mAlb， serum CysC and 25-（OH） VitD were compared among the three groups. Results In the group of no renal damage and the group of renal damage， the urine mALB and serum CysC levels were significantly higher than those in the control group（P<0.05）， and the serum 25-（OH） vitD levels were significantly lower than those in the control group（P<0.05）. The urine mALB and serum CysC levels in the group of renal damage were significantly higher than those in the group of no renal damage（P<0.05）， the serum 25-（OH） vitD level in the group of renal damage was significantly lower than that in the group of no renal damage（P<0.05）. The positive rates of urine mALB， serum CysC， and 25-（OH） vitD in the group of renal damage were 33.3%（10/30）， 26.7%（8/30）， and 30.0% （9/30） respectively， the positive rates of urine mALB， serum CysC， and 25-（OH） vitD in the group of no renal damage were 13.3%（4/30）， 13.3%（4/30）， and 13.3%（4/30） respectively， and the positive rates of urine mALB， serum CysC， and 25-（OH） vitD in the group of no renal damage were 0， 3.3%（1/30）， and 3.3%（1/30） respectively. The positive rates of urine mALB， serum CysC， and 25-（OH） vitD in the group of renal damage and the group of no renal damage were significantly higher than those in the control group（P<0.05）， and the positive rates of urine mALB， serum CysC， and 25-（OH） vitD in the group of renal damage were significantly higher than those in the group of no renal damage（P<0.05）. Conclusion Serum cystatin C and 25 hydroxyvitamin D can be used to diagnose early renal damage in children with Henoch Schonlein purpura， and It has a high clinical value.