万小勇++++++涂传刚++++++邓胜文
[摘要]目的 探讨腰-硬联合麻醉对老年骨科手术患者应激反应及血流动力学的影响。方法 选择2015年2月~2016年2月于我院进行手术治疗的100例老年骨折患者作为研究对象,按照随机数字表法分为观察组与对照组,各50例。对照组予以全身麻醉,观察组采用腰-硬联合麻醉,比较两組的应激反应及血流动力学指标变化。结果 观察组的肾上腺素、血管紧张素、肾素、去甲肾上腺素水平均低于对照组,差异有统计学意义(P<0.05)。两组麻醉前的DBP、SBP、HR指标水平比较,差异无统计学意义(P>0.05)。两组麻醉后10、30 min的DBP、SBP、HR水平较麻醉前均呈现出明显下降趋势,且对照组下降速度更快,差异有统计学意义(P<0.05)。结论 老年骨科手术患者采用腰-硬联合麻醉干预有利于减轻患者的应激反应,改善血流动力学指标,值得临床广泛应用。
[关键词]腰-硬联合麻醉;老年;骨科手术;应激反应;血流动力学
[中图分类号] R614.4 [文献标识码] A [文章编号] 1674-4721(2017)09(c)-0034-03
[Abstract]Objective To investigate the influence of combined spinal-epidural anesthesia (CSEA) on stress response and hemodynamics in senile patients with orthopedic surgery.Methods 100 senile patients with fracture received surgery in our hospital from February 2015 to February 2016 were selected as the research object,and they were divided into the observation group and the control group according to random number table method,50 cases in each group.The patients in control group was given general anesthesia,while the patients in observation group was given CSEA.The stress response and changes of hemodynamic indexes were compared between the two groups.Results The epinephrine,angiotensin,renin,norepinephrine in the observation group was lower than that in the control group,with statistical difference (P<0.05).Before the anesthesia,the level of DBP,SBP,HR between the two groups were compared,there was no statistical difference (P>0.05).After the anesthesia for 10 min and 30 min,the levels of DBP,SBP,HR in the two groups significantly decreased compared with those before anesthesia,and the descend speed of the control group was more quicker,with statistical difference (P<0.05).Conclusion CSEA in senile patients with orthopedic surgery is effective,it can reduce stress response and improve indexes of hemodynamics,which is worthy of clinical application.
[Key words]Combined spinal-epidural anesthesia;Senile;Orthopedic surgery;Stress response;Hemodynamics
老年人群因自身多项功能减退以及骨质疏松的进渐性加重,骨密度减少,使得老年骨折的发生率越来越高[1-2]。据临床数据显示,骨科临床中约有30%以上的患者为老年患者[3]。随着年龄的增长,机体各项器官会出现明显退化,基础疾病多,对手术的耐受程度也随之下降,因此老年患者采用骨科手术治疗所承担的风险也更高,术后并发症及预后不良等情况发生的概率也随之升高[4-5]。已有研究显示,合理有效的麻醉技术与平稳的麻醉状态能降低手术风险,减轻应激反应发生,尽可能减少术后并发症的发生[6-7]。本研究旨在探讨腰-硬联合麻醉对老年骨科手术患者应激反应及血流动力学的影响,现报道如下。
1资料与方法
1.1一般资料
选择2015年2月~2016年2月于我院进行手术治疗的100例老年骨折患者作为研究对象,按照随机数字表法分为观察组与对照组,各50例。观察组中,男32例,女18例;年龄65~87岁,平均(73.46±3.57)岁;体重50~84 kg,平均(68.24±5.46)kg;其中14例全髋关节置换术,26例股骨头置换术,10例膝关节置换术。对照组中,男35例,女15例;年龄64~88岁,平均(74.12±3.96)岁;体重49~85 kg,平均(68.96±5.82)kg;其中15例全髋关节置换术,24例股骨头置换术,11例膝关节置换术。两组的一般资料比较,差异无统计学意义(P>0.05),具有可比性。endprint