Dual primary gastric and colorectal cancer: A complex challenge in surgical oncology

Luigi Marano

Abstract The intricate interplay of colorectal cancer (CRC) and gastric cancer (GC) as dual primary malignancies presents a significant challenge in surgical oncology.CRC is the most common secondary malignancy in GC patients,and vice versa,evidence highlighted by advances in diagnostic procedures and therapy modalities that impact patient survival.A recent study titled “Features of synchronous and metachronous dual primary gastric and colorectal cancer” explores this enigmatic dual malignancy,uncovering crucial insights into the clinical characteristics and prognostic distinctions between synchronous and metachronous presentations.Notably,metachronous cases with a second primary cancer discovered more than six months after the first diagnosis have a better outcome,emphasizing the importance of early detection and treatment.This study underscores the prognostic role of GC stage in patient outcomes.It also sheds light on the complexities faced by synchronous cases,often presenting with unresectable CRC.Surgery-related procedures,like gastrectomy and colon resection,stand out as important predictors of increased survival,necessitating a reevaluation of current therapeutic approaches.A tailored and patient-centered strategy,considering the health of each patient individually and the feasibility of radical treatments,is essential.Continuous follow-up and monitoring are crucial as most second primary cancers arise within five years.In conclusion,early diagnosis,surgical intervention,and watchful surveillance are pivotal in managing dual primary gastric and colorectal cancer patients.Since the incidence of gastric and colorectal cancers continues to rise,the imperative need for further research,ideally with larger sample sizes,becomes evident in our pursuit of comprehensive insights that will refine clinical approaches for this intricate dual malignancy.

Key Words: Multiple primary cancers;Colorectal cancer;Gastric cancer;Dual primary cancers;Synchronous cancers;Metachronous cancers

INTRODUCTION

The intersection of colorectal cancer (CRC) and gastric cancer (GC) as dual primary cancers presents a significant challenge in surgical oncology[1].CRC,with an incidence of 11.4%,ranks among the most frequent tumors associated with multiple primary cancers[2],while GC can evolve into a second primary cancer,with an incidence ranging from 1% to 4.2% in GC patients[3-5].The intricate relationship between these malignancies is bidirectional,with CRC being the most common second primary cancer in GC patients,and GC the most common second primary cancer in CRC patients[6-8].Advances in diagnostic techniques and treatment modalities leading to extended patient survival will likely increase the detection and incidence of multiple primary cancers.This necessitates a comprehensive approach to the evaluation and management of dual primary gastric and CC (DPGCC).A recent study by Linet al[9],titled “Features of synchronous and metachronous dual primary gastric and colorectal cancer”,addresses this complex aspect of surgical oncology,providing valuable insights into the clinical characteristics and prognosis of DPGCC patients.Notably,the study reveals a distinct difference in prognosis between synchronous and metachronous DPGCCs.Patients with metachronous DPGCC exhibited a more favorable prognosis,underlining the significance of early diagnosis and intervention.The study also highlights the high rate of unresectable CC in synchronous DPGCC patients,emphasizing the complexity of managing this dual malignancy.Additionally,it underscores the critical influence of GC stage on patient outcomes,with stage III-IV patients experiencing a considerably worse prognosis.Surgical interventions,such as gastrectomy and colorectal resection,significantly improved survival rates.Regular follow-up and surveillance emerged as crucial components,with the majority of second primary cancers in DPGCC cases occurring within five years.The study’s findings have important implications for tailoring treatment strategies and improving patient outcomes in DPGCC.

SYNCHRONOUS VS METACHRONOUS DPGCC: A PROGNOSTIC GAP

The theory of the etiologic field effect,frequently invoked in the field of multiple primary cancers,offers valuable insights into the pathogenesis and evolution of DPGCC[10].This theoretical framework postulates that the epithelium of the gastrointestinal tract is subjected to a dynamic interplay of genetic and environmental variables,which increases the tendency for carcinogenesis.Both the stomach and the colorectum are equally sensitive to these factors’ effect because they are both essential parts of the continuous mucosal epithelium lining the digestive tract,exposing patients to synchronous or metachronous carcinogenesis.Empirical research confirms a detectable relationship between the initial primary cancer and the second primary cancer in patients with multiple primary neoplasms,highlighting the intricate multifactorial etiology of DPGCC[11-13].This enriches our understanding of the intricate dynamics at play in the DPGCC landscape,shedding light on the relationships governing its occurrence.Importantly,the study’s primary finding,that patients with metachronous DPGCC exhibit a more favorable prognosis compared to synchronous cases,is consistent with previous studies on multiple primary cancers’ prognosis[14-16].This observation underscores the need for tailored treatment strategies and watchful surveillance for patients with synchronous DPGCC,further illuminating the factors influencing this gap in prognosis and refining our approach to managing these challenging cases.

RESECTION AS A PROGNOSTIC KEY FACTOR

The study emphasizes the central role of clinicopathologic characteristics of DPGCC and the inclusion of therapeutic factors in the prognostic analysis[16].Gastrectomy and colorectal resection were associated with better prognosis,highlighting the importance of early diagnosis and surgical intervention.The identification of GC resection as an independent predictor of overall survival aligns with the benefits of surgical intervention in GC[17].This underscores the value of radical surgery in synchronous DPGCC cases,encouraging a reconsideration of treatment strategies and the need for improved diagnostic and therapeutic approaches for this specific dual malignancy.

On the other hand,the research also highlights the high rate of unresectable CC in synchronous DPGCC patients as well as the significant impact of GC stage on patient prognosis,underscoring the importance of early detection and further investigation to identify contributing factors.It is essential to emphasize that the treatment approach for DPGCC remains challenging and multifaceted,requiring individualized evaluation and consideration of patient health and the feasibility of perioperative multidisciplinary treatments associated with radical surgeries.

INTENSIVE FOLLOW-UP: A KEY ISSUE

Early diagnosis and timely intervention are essential in the clinical management of DPGCC[14].The research demonstrates that most second primary cancers in DPGCC cases occur within five years,highlighting the importance of intensive surveillance and follow-up for patients with gastric or CC.Postoperative monitoring of the entire digestive tract is essential,and patients who have extensive resections might need protracted monitoring,underlining the importance of thorough,long-term follow-up to achieve the best outcomes.

CONCLUSION

In conclusion,early diagnosis,surgical resection,and watchful follow-up are essential for managing DPGCC patients.The current literature conclusions call for a reevaluation of therapeutic approaches,particularly in synchronous cases when radical surgery may hold the key to improved outcomes.Furthermore,economic considerations should also be explored to determine the cost-benefit ratio of surveillance strategies.As the incidence of gastric and colorectal cancers continues to rise,the insights derived from this research,as well as the current body of literature,will steer us toward more effective treatment and follow-up strategies for DPGCC.Further research,ideally with larger sample sizes,is imperative to corroborate and expand upon these findings,thereby offering a more comprehensive understanding of DPGCC and guiding more effective clinical approaches in the future.

FOOTNOTES

Author contributions:Marano L designed the overall concept and outline of the manuscript,wrote and edited the manuscript and review of literature.

Conflict-of-interest statement:The author reports no relevant conflicts of interest for this article.

Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers.It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license,which permits others to distribute,remix,adapt,build upon this work non-commercially,and license their derivative works on different terms,provided the original work is properly cited and the use is non-commercial.See: https://creativecommons.org/Licenses/by-nc/4.0/

Country/Territory of origin:Poland

ORCID number:Luigi Marano 0000-0002-9777-9588.

S-Editor:Wang JJ

L-Editor:A

P-Editor:Zhang XD