N-Heterocyclic carbene catalyzed C-acylation reaction for access to linear aminoenones

Jie Lv,Yingling Nong,Kai Chen,Qingyun Wang,Jiamiao Jin,Tingting Li,Zhichao Jin,Yonggui Robin Chi

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering,Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education,Guizhou University,Guiyang 550025,China

Keywords:N-Heterocyclic carbene Organocatalysis C-Acylation reaction Animoenone synthesis

ABSTRACT An N-heterocyclic carbene (NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linear β-aminoenone products.The β-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild conditions.The reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.

Cyclopropyl carbonyl derivatives are widely found in natural products with proven biological activities and have significant applications in medicinal research and pesticide development (Fig.1)[1–11].For example,S-Bioallethrin and Cyhalothrin are commercially available insecticides that are widely used on crops for pest control.Cilastatin sodium is a popular antibiotic drug for the treatment of various infections.Milnacipran hydrochloride is an antidepression drug and can also be used for the treatment of fibromyalgia symptom.Prasugrel is an ADP (adenosine diphosphate) receptor (P2Y12) antagonist that can inhibit platelet aggregation and decrease the risk of coronary syndromes and stroke in patients.Therefore,the development of simple and efficient approaches for the synthesis of cyclopropyl carbonyl derivatives with multiple functionalities have received considerable attention.

N-Heterocyclic carbenes (NHCs) have been extensively explored as organocatalysts for the preparation of various functional molecules [12–29].Ketones are one class of the most significant functional molecules in both synthetic chemistry[30–34] and biological research [35–37].They can be efficiently afforded from NHC organocatalytic reactions (Scheme 1).For instance,linear ketones can be obtained from NHC-catalyzed singleelectron transfer processes (SET) by using carbaldehyde/carboxylic acid derivatives as the starting materials [38–52].An alkyl radical precursor bearing a redox active leaving group is generally involved in these processes (Scheme 1a(1)).They can also be efficiently affordedviaStetter reactions using aldehydes and various electron-deficient alkene/alkyne molecules as the reaction substrates (Scheme 1a(2)) [53–57].NHC-catalyzed ionic carbonyl nucleophilic substitution reactions can be used as effective tools for the synthesis of ketone molecules as well (Scheme 1b(1)) [58–75].Cyclic ketones bearing multiple functional groups are generally formed in this case.For example,theα,β-unsaturated aldehyde can be activated by an NHC catalyst as a nucleophile to react with an electron-deficient alkene substrateviaa homoenolate [3+2] cycloaddition reaction to give the multi-substituted cyclopentanone as the final product (Scheme 1b(1)) [58–63].The oxidative [4+2] cycloaddition reaction between theβ-methylα,β-unsaturated aldehyde and the electron-deficient alkene substrate promoted by an NHC catalyst can also be used for cyclic unsaturated ketone syntheses (Scheme 1b(2)) [64–71]].Theα,βunsaturated aldehyde can react as a dielectrophile with the tetra-substituted electron-deficient alkene substrate under NHCcatalyzed oxidative conditions to give the multi-functionalized cyclohexadienone product (Scheme 1b(3)) [72,74].To the best of our knowledge,the formation of linear ketone moleculesviaNHCcatalyzed carbonyl nucleophilic substitution reactions has never been reported.

Herein,we disclose an NHC-catalyzed oxidativeC-acylation reaction between the 1-cyclopropylcarbaldehydes 1 [76–78] and the aryl methyl ketimine substrates 2 [79–81] to give theα,β-unsaturated ketones 3 bearing aβ-amino group in moderate to excellent yields as single diastereomers (Scheme 1c).Mechanistically,the aldehyde substrate 1 can react with NHC catalyst under oxidative conditions to generate the acyl azolium intermediate I.The Lewis acidic Zn(OTf)2can help bring affinities between the acyl azolium intermediate I and the enamine intermediate II (generated from deprotonation of the imine substrate 2).An electrophilic enamineC-acylation/proton transfer cascade process leads to the formation of the target enone product,with the free NHC catalyst released for additional catalytic cycles.

Scheme 1.NHC-catalyzed ketone syntheses.

Fig.1.Bioactive molecules containing cyclopropyl carbonyl skeleton.

The racemic 1-cyclopropylcarbaldehyde 1a was chosen as the model substrate to react with theN-sulfonyl imine 2a to test the reaction conditions,with key results summarized in Table 1.We initially tested the reaction using various NHC catalysts in the pres-ence of Cs2CO3and DQ oxidant in THF at 35°C for 17 h (Table 1,entries 1–6).The non-chiral NHC catalysts bearing electron-richNaryl substituents (e.g.,A & B) were not efficient for this transformation (entries 1 and 2).The target product 3a can be afforded in a promissing yield when using the NHC catalyst C bearingN-2,4,6-trichlorophenyl group (entry 3).Further decreasing the electron density of the NHC catalyst resulted in no formation of the desired product (entry 4,D).Therefore,different catalyst scaffolds were evaluated with the 2,4,6-trichlorophenyl group used as the NHCNsubstituent (entries 5 and 6).To our delight,the target product 3a can be afforded in a moderate yield when using the aminoindanolderived NHC catalyst F (entry 6) [82].Changing the basic additive into other organic or inorganic bases could not improve the reaction yields (entries 7–9).The reaction could also be carried out in a variety of organic solvents (entries 10–12),and the yield of product 3a could be futher improved to 62% when using DCM as the reaction solvent (entry 10).Lewis acids have been proven to be beneficial to a number of NHC-catalyzed transformations in both reaction efficiency and stereoselectivity.In this regard,a diversity of Lewis acids were tested and Zn(OTf)2[83–89] was found as the most suitable promoter for the transformation,with the product yield dramatically improved to 91% (entry 14).The Lewis acidic Zn(OTf)2was believed to act as coordinators that could bring both of the reactive intermediates close to each other to facilitate the catalytic reaction process.

Table 1 Condition optimization.a

With the optimal reaction conditions at hand (Table 1,entry 14),we next examined the reaction scope of the 1-cyclopropylcarbaldehydes 1 bearing different substituents and substitution patterns (Scheme 2).Electron-donating groups are well tolerated on each position of the phenyl ring of the 1-cyclopropylcarbaldehyde 1a,with the target functionalβaminoenone products (3b-3e) afforded in excellent yields as single diastereoisomers.In contrast,substitutions on the phenyl ring of the cyclopropylcarbaldehyde 1a with electron-withdrawing groups generally give the products in relatively lower yields,regardless of their substitution positions (3f-3k).The phenyl ring of the substrate 1a could be also switched to a heteroaromatic thiophenyl group,with the desriedβ-aminoenone product 3l afforded in 67%yield as a single diastereomer.Replacing the phenyl group of 1a with an alkyltBu group led to no desired product,with the imine substrate remained unchanged.Noteworthily,aldehyde substrates without an electron-deficient 1-cyclopropyl group are not efficient in this transformation.

Scheme 2.Scope of the 1-cyclopropylcarbaldehydes 1.Reaction conditions as stated in Table 1,entry 14.Yields were isolated yields after purification via SiO2 column chromatography.The dr values were determined via 1H NMR on the crude reaction mixture.

Scheme 3.Scope of the N-sulfonyl imines 2.Reaction conditions as stated in Table 1,entry 14.Yields were isolated yields after purification via SiO2 column chromatography.The dr values were determined via 1H NMR on the crude reaction mixture.

We then examined the scope of theN-sulfonyl imine substrates 2 (Scheme 3).Substituents with various electronic properties could be installed on each position of the phenyl rings of theN-sulfonyl imines 2,with the corresponding products obtained in good to excellent yields as single diastereoisomers (Scheme 3,3m-3t).Replacing the phenyl group with a thiophenyl group in theN-sulfonyl imine 2a could afford the desired product 3u in 91% yield.Note that,the phenyl ring of theN–sulfonyl imine 2a could also be replaced by a naphthyl ring,and the yield of the target product 3v was slightly decreased.However,switching the phenyl group of theN-sulfonyl imine 2a into an aliphatictBu group resulted in no formation of the desired product,with the imine substrate remained unchanged.It is also worthy to note that no desired product could be observed when the R3on theN-sulfonyl imine 2 was a methyl or a Br group.As a technical note,all the enone products are afforded asZ-isomers from our approach,which is probably due to the stablization effects by the intramolecular H-bonding interaction.Noteworthily,theN-Ts group of the imine 2a could also be converted to anN-Ms group,with the desired product 3w obtained in 31% yield under the currently optimized condition.However,no target product was observed when theN-Ts group of the imine 2a was replaced by anN-Ph group.

The NHC-catalyzed C-acylation reaction between 1a and 2a can be carried out at 1.0-mmol scale without much erosion on the product yield (Fig.2a).We have also explored the enantioselective dynamic kinetic resolution (DKR) reaction between 1a and 2a using various chiral NHC catalysts (e.g.,G) (Fig.2b).Theβ-aminoenones could be obtained in the a moderateervalue at the current stage.

Fig.2.A 1.0-mmol scale synthesis and an enantioselective synthesis of 3a.

Scheme 4.Synthetic transformation of 3a.

Theβ-aminoenones 3 containing cyclopropyl fragments can be easily transformed into novel multifunctional molecules (Scheme 4).For instance,the Ts group of theβ-aminoenone 3a can be removed by sulfuric acid to give the product 4 in an excellent yield as a single diastereoisomer.Theβ-aminoenone 3a can react with BzCl to afford the product 5 in 84% yield.The carbonyl group of 3a can be methylated by the Grignard reagent,with the product 6 afforded in 88% yield.Besides,the cyclopropyl fragments of 3a can also undergo a ring-opening reaction to obtain the linear ketone product 7 in moderate yield.

In summary,we have developed the first NHC-catalyzed carbonyl nucleophilic substitution reaction for quick and efficient access to linear ketone molecules.β-Aminoenones bearing electrondeficient cyclopropyl fragments are afforded in moderate to excellent yields as single diastereomers.The products featuretransdiastereoselective substitutions on the cyclopropyl ring motif andZsubstitutions around the C=C double bond.Further investigations towards highly enantioselective approaches for the DKRCacylation reaction and the applications of theβ-aminoenone products in novel pestcide development are in progress in our laboratories.

Declaration of competing interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Acknowledgments

We acknowledge the financial support from the National Natural Science Foundation of China (Nos.21772029,32172459,21961006,22001173),The 10 Talent Plan (Shicengci) of Guizhou Province (No.[2016]5649),the Science and Technology Department of Guizhou Province (Nos.[2019]1020,Qiankehejichu-ZK[2021]Key033),the Program of Introducing Talents of Discipline to Universities of China (111 Program,No.D20023) at Guizhou University,Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[No.Qianjiaohe KY (2020)004],the Guizhou Province First-Class Disciplines Project (No.GNYL(2017)008),and Guizhou University(China).

Supplementary materials

Supplementary material associated with this article can be found,in the online version,at doi:10.1016/j.cclet.2022.05.084.