乙型肝炎病毒感染患者发生原发性肝癌的影响因素

汤佳媚　周晓玲　沈晓萍　包剑锋

[關键词] 乙型肝炎病毒;原发性肝癌;肝硬化;影响因素;危险因素

[中图分类号] R735.7          [文献标识码] B          [文章编号] 1673-9701（2021）22-0050-04

Impacting factors of primary hepatocellular carcinoma in patients with hepatitis B virus infection

TANG Jiamei1   ZHOU Xiaoling1   SHEN Xiaoping1   BAO Jianfeng2

1.Department of Hepatobiliary and Pancreatic Surgery， Xixi Hospital of Hangzhou， Hangzhou   310023， China; 2.Department of Severe Hepatopathy， Xixi Hospital of Hangzhou， Hangzhou   310023， China

[Abstract] Objective To investigate the related factors of primary hepatocellular carcinoma（PHC） in patients with hepatitis B virus infection and put forward early preventive measures. Methods PHC patients admitted to and treated in our hospital from January 2017 to December 2020 were selected as the case group（n=316）， and hepatitis B patients without liver cancer in the same period were randomly selected as the control group（n=316）. The differences of factors such as gender， age， body mass index， educational background， long-term smoking history， long-term drinking history， frequency of eating fried food， family history of liver cancer， diabetes， hypertension， liver cirrhosis， fatty liver， no antiviral treatment， hepatitis B virus load， e antigen and frequency of emotional irritability were compared between the two groups. Then， stepwise logistic regression was adopted to screen the related risk factors of PHC in patients with hepatitis B. Results There were statistically significant differences in long-term smoking history， long-term drinking history， frequency of eating fried food， family history of liver cancer， diabetes， liver cirrhosis， fatty liver， no antiviral treatment， hepatitis B virus load， e antigen， frequency of emotional irritability and other factors between the two groups （P<0.05）. The risk factors of PHC impacting patients with hepatitis B included long-term drinking history （OR=4.166）， family history of liver cancer （OR=3.114）， liver cirrhosis （OR=5.436）， fatty liver （OR=3.699）， no antiviral treatment （OR=4.455）， hepatitis B virus load （OR=3.518） and frequency of emotional irritability （OR=2.527）， etc. Conclusion There are many high-risk factors of PHC impacting patients with hepatitis B， so targeted prevention and control should be carried out as soon as possible to reduce the incidence of liver cirrhosis and PHC and improve the prognosis of patients.