中药汤剂对绝经后妇女乳腺癌的干预作用及炎症因子的影响

何维华 钟钰 彭卫卫 陈贱兰

摘 要 目的：探討中药汤剂对绝经后妇女乳腺癌的干预作用及炎症因子的影响。方法：收集2019年7月—12月诊治的绝经后乳腺癌患者60例，随机分为观察组和对照组各30例，对照组给予来曲唑2.5 mg/次，1次/d；阿托伐他汀钙片20 mg/次，1次/d；共治疗1个月。观察组在此基础上早、晚口服中药汤剂各200 ml，共治疗1个月。比较两组治疗效果及治疗前后炎症因子、中医症候积分和骨密度变化情况。结果：观察组临床控制率为73.33%（22/30），高于对照组的43.33%（13/30，P<0.05）；总有效率为90.00%（27/30），高于对照组的66.67%（20/30，P<0.05）。治疗后，观察组的炎症因子水平均显著低于对照组（P<0.05）；中医症候积分显著低于对照组（P<0.05）；腰椎骨密度及股骨颈骨密度显著高于对照组P<0.05）。结论：中药汤剂配合西药治疗绝经后妇女乳腺癌疗效显著，可明显改善患者炎症因子和骨密度水平。

关键词 乳腺癌；绝经后；中药汤剂；炎症因子

中图分类号：R737.9 文献标志码：A 文章编号：1006-1533（2020）22-0022-03

Effect of traditional Chinese medicine decoction on breast cancer and inflammatory factors in postmenopausal women

HE Weihua1， ZHONG Yu2， PENG Weiwei3， CHEN Jianlan4（1. Pharmacy Department of Peoples Hospital of Ganzhou， Jiangxi 341000， China； 2. Obstetrics and Gynecology Department of Red Cross Hospital of Rongjiang New District， Ganzhou， Jiangxi 341000， China； 3. Oncology Department of Peoples Hospital of Ganzhou， Jiangxi 341000， China； 4. Clinical Laboratory of Peoples Hospital of Ganzhou， Jiangxi 341000， China）

ABSTRACT Objective： To investigate the effect of the traditional Chinese medicine decoction on breast cancer and inflammatory factors in postmenopausal women. Methods： Sixty postmenopausal patients with breast cancer diagnosed and treated from July to December 2019 were collected and randomly divided into an observation group and a control group with 30 cases in each group. The control group was given letrozole 2.5 mg/time， once a day； atorvastatin calcium tablets 20 mg/ time， once a day； a total of treatment was 1 month. On this basis， the observation group took 200 ml of traditional Chinese medicine decoction in the morning and in the evening for a total of 1 month of treatment. The treatment effects and changes of inflammatory factors， TCM syndrome scores and bone mineral density before and after treatment were compared between the two groups. Results： The clinical control rate was 73.33%（22/30） in the observation group， which was higher than 43.33% in the control group（13/30， P<0.05）； the total effective rate was 90.00%（27/30） in the observation group， which was higher than the 66.67% in the control group（20/30， P<0.05）. After treatment， the levels of inflammatory factors in the observation group were significantly lower than those in the control group （P <0.05）； the TCM symptom score in the observation group was significantly lower than that in the control group （P < 0.05）； the bone mineral density of lumbar spine and femoral neck in the observation group were significantly higher than those in the control group（P<0.05）. Conclusion： The traditional Chinese medicine decoction combined with western medicine has a significant effect in the treatment of breast cancer in postmenopausal women， and can significantly improve the level of inflammatory factors and bone mineral density in patients.