左甲状腺素钠治疗老年甲状腺功能减退综合征的有效性

刘海英　罗玉

【摘要】 目的：探究左甲状腺素钠治疗老年甲状腺功能减退综合征的有效性。方法：选取2016年12月-2018年12月于笔者所在医院接受治疗的72例老年甲状腺功能减退综合征患者，分为观察组和对照组，每组36例。对照组给予甲状腺片治疗，观察组给予左甲状腺素钠治疗。对比两组治疗总有效率及甲状腺功能各项指标水平。结果：观察组治疗后FT4明显高于对照组，TSH、FT3均明显低于对照组（P<0.05）。治疗后，两组FT4与FT3均明显高于治疗前，TSH明显低于治疗前（P<0.05）。对照组总有效率为83.33%，显著低于观察组的97.22%（P<0.05）。结论：针对老年甲状腺功能减退综合征患者采用左甲状腺素钠治疗，可有效改善甲状腺功能，提高治疗有效率，具有广泛的应用价值。

【关键词】 老年甲状腺功能减退; 左甲状腺素钠; 有效性

doi：10.14033/j.cnki.cfmr.2019.20.049 文献标识码 B 文章编号 1674-6805（2019）20-0-02

Efficacy of Levothyroxine Sodium in the Treatment of Senile Hypothyroidism Syndrome/LIU Haiying，LUO Yu.//Chinese and Foreign Medical Research，2019，17（20）：-112

【Abstract】 Objective：To investigate the effectiveness of Levothyroxine Sodium in the treatment of senile hypothyroidism syndrome.Method：72 elderly patients with hypothyroidism were selected from December 2016 to December 2018.The patients were divided into the observation group and the control group，and 36 cases in each group.The control group was treated with Thyroid Tablet and the observation group was treated with Levothyroxine Sodium.The total effective rate and the level of thyroid function indexes of the two groups were compared.Result：After treatment，the level of FT4 in the observation group was significantly higher than that of the control group，and TSH and FT3 were significantly lower than those of the control group（P<0.05）.After treatment，FT4 and FT3 levels of the two groups was significantly higher than before treatment，and TSH was significantly lower than before treatment（P<0.05）.The total effective rate of the control group was 83.33%，which was significantly lower than 97.22% of the observation group（P<0.05）.Conclusion：The use of Levothyroxine Sodium in the treatment of elderly patients with hypothyroidism syndrome can improve thyroid function effectively，improve the effective rate of treatment，and have wide application value.

【Key words】 Senile hypothyroidism; Levothyroxine Sodium; Effectiveness

First-authors address：The Fifth Peoples Hospital of Sichuan Province，Mianyang 610031，China

甲狀腺功能减退综合征，为临床上常见的一种慢性疾病，记忆力衰退、嗜睡、疲乏、认知损伤等为常见临床症状，多发生于老年人群，对患者的生活质量产生严重影响[1]。引起老年人甲状腺功能减退综合征主要原因为甲状腺激素合成、分泌不足，生物效应下降[2]。此次研究针对老年甲状腺功能减退综合征患者进行左甲状腺素钠治疗，分析药物的有效性，结果如下。

1 资料与方法

1.1 一般资料

选取2016年12月-2018年12月于笔者所在医院接受治疗的72例老年甲状腺功能减退综合征患者。纳入标准：来院治疗前未服用降脂药物;无糖尿病、肾病、恶性肿瘤等疾病史。将72例患者分为观察组和对照组，每组36例。观察组男26例，女10例;年龄60～80岁。对照组男24例，女12例;年龄62～82岁。两组一般资料对比，差异均无统计学意义（P>0.05），有可比性。研究经医院伦理委员会批准，患者均自愿参与且签署知情同意书。