米诺环素联合甲硝唑凝胶治疗慢性牙周炎的临床效果及不良反应发生率影响观察

樊晶　蔡上

[摘要] 目的 觀察并探讨米诺环素联合甲硝唑凝胶治疗慢性牙周炎的临床效果及不良反应发生率。 方法 方便选取2018年1—8月期间的70例慢性牙周炎患者当作研究对象。根据用药治疗方案的不同，将70例慢性牙周炎患者分为2组，各35例。研究组联合应用米诺环素、甲硝唑凝胶进行治疗，对照组单一应用米诺环素进行治疗。观察并比较2组的临床治疗效果及不良反应发生率。结果 研究组的总有效率94.29%明显高于对照组的总有效率74.29%，差异有统计学意义（χ2=7.564，P=0.003）;研究组的龈沟出血指数（1.63±0.25）分、菌斑指数（0.81±0.22）分、牙龈指数（1.25±0.32）分、 牙齿松动度（0.65±0.15）mm、牙周袋深度（1.85±0.53）mm明显低于对照组的龈沟出血指数（2.32±0.45）分、菌斑指数（1.21±0.23）分、牙龈指数（2.05±0.26）分、牙齿松动度（1.52±0.34）mm、牙周袋深度（2.31±0.62）mm，差异有统计学意义（t=6.584、5.132、7.521、6.981、7.614，P=0.015、0.024、0.003、0.011、0.003）;研究组的不良反应发生率5.71%明显低于对照组的不良反应发生率22.86%，差异有统计学意义（χ2=7.981，P=0.002）。 结论 米诺环素联合甲硝唑凝胶治疗慢性牙周炎，疗效确切，不良反应发生率低，安全性高，值得推广。

[关键词] 米诺环素;甲硝唑凝胶;慢性牙周炎

[中图分类号] R781          [文献标识码] A          [文章编号] 1674-0742（2019）04（b）-0130-03

[Abstract] Objective To observe and investigate the clinical effects and incidence of adverse reactions of minocycline combined with metronidazole gel in the treatment of chronic periodontitis. Methods Seventy patients with chronic periodontitis between January 2018 and August 2018 were convenient selected and enrolled. According to the different treatment regimens， 70 patients with chronic periodontitis were divided into 2 groups， 35 cases each. The study group was treated with minocycline and metronidazole gel， and the control group was treated with minocycline alone. The clinical effects and adverse reactions of the two groups were observed and compared. Results The total effective rate of the study group was 94.29%， which was significantly higher than the total effective rate of the control group （74.29%）. The difference was statistically significant （χ2=7.564， P=0.003）. The sulcus bleeding index of the study group （1.63±0.25）points， the plaque index （0.81±0.22）points， the gingival index （1.25±0.32）points， the tooth looseness （0.65±0.15） mm， and the periodontal pocket depth（1.85±0.53） mm were significantly lower than the sulcus bleeding index of the control group of （2.32±0.45）points， plaque index （1.21±0.23）points， gingival index （2.05±0.26）points， tooth looseness （1.52±0.34） mm， periodontal pocket depth （2.31±0.62） mm， the difference is statistically significant（t=6.584， 5.132， 7.521， 6.981， 7.614， P=0.015， 0.024， 0.003， 0.011， 0.003）; the incidence of adverse reactions in the study group was 5.71% significantly lower than the incidence of adverse reactions in the control group 22.86%， The difference was statistically significant （χ2=7.981， P=0.002）. Conclusion  Minocycline combined with metronidazole gel is effective in the treatment of chronic periodontitis. The incidence of adverse reactions is low and the safety is high. It is worthy of promotion.