时间调节诱导化疗联合调强放疗同期洛铂化疗治疗局部晚期头颈部鳞癌的效果

郭立仪 邓明辉 吕莉

[摘要]目的 探討局部晚期头颈部鳞癌患者临床联合接受时间调节诱导化疗、调强放疗同期洛铂化疗的临床效果。方法 选取2014年4月～2017年4月我院的60例局部晚期头颈部鳞癌患者作为研究对象，采用随机分组方法将其分为观察组和对照组，各30例患者。对照组接受时间调节诱导化疗，观察组联合接受时间调节诱导化疗、调强放疗同期洛铂化疗，比较两组的不良反应发生率、总有效率、1年内总生存率、无进展生存率以及无局部复发生存率。结果 观察组的总有效率为60.00%，高于对照组的30.00%，差异有统计学意义（P<0.05）。观察组的不良反应总发生率为23.33%，与对照组的20.00%比较，差异无统计学意义（P>0.05）。观察组的治疗后1年内总生存率、无进展生存率以及无局部复发生存率分别为80.00%、60.00%、56.67%，高于对照组的53.33%、33.33%、30.00%，差异有统计学意义（P<0.05）。结论 时间调节诱导化疗联合调强放疗同期洛铂化疗治疗局部晚期头颈部鳞癌效果满意，不良反应程度较轻，患者能够耐受，具有临床应用价值。

[关键词]局部晚期头颈部鳞癌;时间调节诱导化疗;调强放疗;同期洛铂化疗;治疗

[中图分类号] R739.91          [文献标识码] A          [文章编号] 1674-4721（2019）1（b）-0068-03

[Abstract] Objective To investigate the clinical effect of combined time-modulated induction chemotherapy and intensity-modulated radiotherapy with concurrent lobaplatin chemotherapy in locally advanced head and neck squamous cell carcinoma. Methods Altogether 60 patients with locally advanced head and neck squamous cell carcinoma from April 2014 to April 2017 were selected and randomly divided into the observation group and the control group， 30 cases in each group. The control group was treated with time-modulated induction chemotherapy. The observation group was treated with time-modulated induction chemotherapy and intensity-modulated radiotherapy combined with concurrent Lobaplatin chemotherapy. The incidence of adverse reactions， total effective rate， one-year overall survival rate， progression-free survival rate and local recurrence-free survival rate were compared between the two groups. Results The total effective rate of the observation group was 60.00%， which was higher than that of the control group （30.00%）， with statistically significant difference （P<0.05）. The total incidence of adverse reactions of the observation group was 23.33%， compared with the control group （20.00%）， there was no statistically significant difference （P>0.05）. The one-year overall survival rate， progression-free survival rate and local recurrence-free survival rate of the observation group were 80.00%， 60.00% and 56.67% respectively， which was higher than those of the control group （53.33%， 33.33% and 30.00%）， with statistically significant difference （P<0.05）. Conclusion Time-modulated induction chemotherapy combined with intensity-modulated radiotherapy combined plus concurrent Lobaplatin chemotherapy for locally advanced head and neck squamous cell carcinoma has a satisfactory effect with mild adverse reactions， which can be tolerated by patients and has clinical value.