腹腔镜术后联合戈舍瑞林治疗巧克力囊肿的效果

李小红

[摘要]目的 比较巧克力囊肿患者腹腔镜术后联合孕三烯酮与戈舍瑞林治疗的临床效果。方法 将我院2014年1月～2015年11月收治的72例巧克力囊肿患者作为观察对象，依照随机数字表法分为对照组（n=36）和观察组（n=36）。两组均给予腹腔镜术治疗，在此基础上，对照组加用孕三烯酮，观察组加用戈舍瑞林，对两组患者体内激素水平、临床疗效、妊娠率进行比较。结果 在激素水平方面，两组治疗后血清卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）水平显著降低（P<0.05），但组间血清FSH、LH水平比较差异无统计学意义（P>0.05），而观察组血清E2水平显著低于对照组（P<0.05）。在总有效率、妊娠率方面，观察组者均高于对照组，分别为83.3% vs.61.1%、63.9% vs.38.9%，组间比较差异有统计学意义（P<0.05）。结论 巧克力囊肿患者腹腔镜术后联合戈舍瑞林临床效果更加显著，不仅可降低患者激素水平，还可提高妊娠率，值得临床进一步应用与借鉴。

[关键词]巧克力囊肿；腹腔镜术；孕三烯酮；戈舍瑞林；临床效果

[中图分类号] R713.4 [文献标识码] A [文章编号] 1674-4721（2018）5（b）-0095-03

Effect of Goserelin combined after laparoscopic surgery treating chocolate cyst

LI Xiao-hong

Department of Gynecology，People′s Hospital of Maoming City，Guangdong Province，Maoming 525000，China

[Abstract]Objective To compare the clinical effect of laparoscopic surgery in patients with chocolate cyst combined with Gestrinone and Goserelin treatment.Methods 72 patients with chocolate cyst treated in our hospital from January 2014 to November 2015 were selected as observation subjects and divided into control group （n=36） and observation group （n=36） according to random number table method.Both groups were given laparoscopic treatment.On this basis，the patients in the control group were given Gestrinone and the patients in the observation group were given Goserelin.The levels of hormone，clinical efficacy and pregnancy rate in both groups were statistically analyzed.Results In hormone levels，two groups of after treatment，serum follicle stimulating hormone （FSH），luteinizing hormone （LH），estradiol （E2） level were significantly decreased（P<0.05），but the groups of serum FSH，there was no significant difference between the level of LH（P>0.05），and the serum E2 level of observation group was significantly lower than the control group （P<0.05）.In terms of the total effective rate，pregnancy rate，the observation group were higher than that in the control group，the data were 83.3% vs. 61.1%，63.9% vs.38.9%，there was a significant difference between groups （P<0.05）.Conclusion The clinical effect of Goserelin for chocolate cyst patients after laparoscopic surgery is more significant，not only can reduce the hormone level of patients but also can improve the pregnancy rate，which is worthy of further application and clinical reference.

[Key words]Chocolate cyst；Laparoscopy；Gestrinone；Goserelin；Clinical effect

巧克力囊肿是子宫内膜异位症的一种类型，发病率为50%～70%[1]，若单纯给予手术治疗，治愈率較低，复发率较高，因此，对希望保留卵巢功能的患者来说，多联合药物治疗，以此巩固治疗效果[2]。现今，孕三烯酮、戈舍瑞林作为促性腺激素释放激素类似物（GnRHa）药物，在临床中得到了普遍应用，且具有一定的临床疗效[3-4]。为了进一步探讨孕三烯酮、戈舍瑞林的治疗效果，本研究现对我院收治的巧克力囊肿患者进行探究，比较腹腔镜术联合孕三烯酮与戈舍瑞林治疗的临床效果，现报道如下。