降钙素和癌胚抗原联合检测在甲状腺髓样癌诊治中的意义

陈明光

[摘要] 目的 分析降钙素和癌胚抗原联合检测在甲状腺髓样癌诊治中的意义。 方法 方便收取该院20例甲状腺髓样癌患者作为观察组，再收取20名健康体检者作为对照组，收取时间在2010年2月—2015年3月，实施化学发光法检测两种受检者癌胚抗原、降钙素水平。结果 患者术后6 d癌胚抗原（3.12±0.89）ng/mL、降钙素水平（9.59±3.29）ng/mL与术前1 d相比显著降低，而复发时癌胚抗原、降钙素水平与术后6 d相比，显著升高（P<0.05），观察组患者降钙素（120.04±23.49）pg/mL、癌胚抗原水平（15.01±4.23）ng/mL高于对照组健康体检者（P<0.05），联合检查的敏感性显著高于单一检查（P<0.05）。结论 降钙素和癌胚抗原联合检测能提高甲状腺髓样癌的敏感性，利于早期治疗和早期检测，同时还能判断患者肿瘤复发和手术效果。

[关键词] 降钙素；癌胚抗原；甲状腺髓样癌

[中图分类号] R736 [文献标识码] A [文章编号] 1674-0742（2017）06（b）-0007-03

[Abstract] Objective To analyze the significance of combined test of Calcitonin and carcinoembryonic antigen in diagnosis and treatment of medullary carcinoma of thyroid gland. Methods Convenient selection 20 cases of patients with medullary carcinoma of thyroid gland admitted and treated in our hospital were selected as the observation group， 20 cases of healthy physical examination persons were selected as the control group and the admission time was from February 2010 to March 2015， and the calcitonin and carcinoembryonic antigen levels of the two groups were tested by the chemiluminescence method. Results On 6 d after operation， the carcinoembryonic antigen（3.12±0.89）ng/mL and calcitonin （9.59±3.29）ng/mL were obviously decreased compared with those in 1 d before operation， and the calcitonin and carcinoembryonic antigen levels at recurrence were obviously increased compared with those in 6 d after operation（P<0.05）， and the calcitonin and carcinoembryonic antigen levels in the observation group were respectively （120.04±23.49）pg/mL and （15.01±4.23）ng/mL， which were higher than those in the control group（P<0.05）， and the sensitivity of combined examination was obviously higher that of the single examination（P<0.05）. Conclusion The calcitonin and carcinoembryonic antigen can improve the sensitivity of medullary carcinoma of thyroid gland， which is conducive to the early treatment and test， and it can also determine the tumor recurrence and operation effect.

[Key words] Calcitonin； Carcinoembryonic antigen； Medullary carcinoma of thyroid gland

甲狀腺髓样癌为临床上常见的内分泌系统恶性肿瘤，由于该种肿瘤预后差、恶性程度高，而早发现、早诊断对甲状腺髓样癌患者十分重要。在临床中甲状腺髓样癌无公认肿瘤标志物，而如何增加甲状腺髓样癌的检出率为临床主要研究目的[1-2]。因此，该院对降钙素和癌胚抗原联合检测在甲状腺髓样癌诊治中的意义进行分析，方便选取2010年2月—2015年3月该院收治的20例甲状腺髓样癌患者进行研究，现报道如下。

1 资料与方法

1.1 一般资料

方便收取该院收治的20例甲状腺髓样癌患者作为观察组，再收取20名健康体检者作为对照组。纳入标准：①20例患者经病理和手术结果证实为甲状腺髓样癌，②两组受检者均签署知情同意书，参与该次研究。排除标准：①甲状腺疾病、其他恶性肿瘤、慢性肾病、甲状旁腺疾病、神经内分泌肿瘤患者，②在7 d内采用口服补钙和静脉补钙患者。观察组患者；年龄在20～50岁之间，患者平均年龄为（36.01±1.16）岁，男性患者有10例、女性患者有10例。对照组；年龄在20～51岁之间，平均年龄为（37.21±1.24）岁，男性健康体检者有9名、女性体检者有11名。观察组甲状腺髓样癌患者、对照组健康体检者的各项资料差异无统计学意义（P>0.05），可进行对比。