Nicotine transdermal patch for smoking cessation using combination of hydrophilic and hydrophobic polymers as matrix flm formers

Danaipat Sukphong,Thesisanin Rojanaratha,Marut Srivarnitpoom, Chaisan Sriwichupong,Garnpimol C.Ritthidej

Pharmaceutics and Industrial Pharmacy,Faculty of Pharmaceutical Science,Chulalongkorn University, Bangkok,Thailand

Nicotine transdermal patch for smoking cessation using combination of hydrophilic and hydrophobic polymers as matrix flm formers

Danaipat Sukphong*,Thesisanin Rojanaratha,Marut Srivarnitpoom, Chaisan Sriwichupong,Garnpimol C.Ritthidej

Pharmaceutics and Industrial Pharmacy,Faculty of Pharmaceutical Science,Chulalongkorn University, Bangkok,Thailand

A R T I C L E I N F O

Article history:

Available online 25 November 2015

Nicotine

Transdermal patch

Eudragit

Hydroxypropyl methylcellulose

One of the most popular nicotine replacement therapies(NRTs) available in the market nowadays is the nicotine patches,which provide a source of nicotine to reduce the withdrawal symptoms experienced when smoking is stopped.Nicotine transdermal patch to satisfy addicted smoker’s cravings as oninvasive,self medicated therefore patient compliance and less frequent administration than oral was investigated to contain 2 layers;backing layer,adhesive with drug layer.Several polymers such as hydroxypropyl methylcellulose(HPMC)E5, PEG4000,PVP K30,Eudragit E100,maltodextrin,polyvinyl alcohol (PVA),xanthan gum and carbopol were used as flm formers; polyethylene glycol(PEG)400,triacetin,propylene glycol and glycerin were used as plasticizers.Polymers and plasticizers were able to form homogeneous mixture,and the patches were easily prepared by pouring them into plates followed by drying them in a hot air oven at 50°C for 4 hours.Finally,the patches were evaluated to study the effect of type and content of polymers and plasticizers that were suitable for transdermal patch such as thickness,tensile strength,Young’s modulus,internal structure,drug release and drug content following USP monograph.

Eudragit E100 with HPMC E5,PEG4000,and PVP K30 produced satisfactorily clear and elastic flms(Fig.1a)with satisfactory mechanical properties,determined from a universal tensile tester.HPMC E5,PEG4000 and PVP K30 could form pores due to their water solubility,thus increased drug release. When using PVA,maltodextrin,xanthan gum and carbopol, unclear flm was obtained.For PEG400,triacetin and propylene glycol as plasticizer,glycerin was not suitable because flm characteristic was too sticky.The amount of Eudragit E100 signifcantly affected the drug release,while slight alteration in drug release was observed from other polymers(Fig.1b).The results indicated that the polymeric patches composed of these polymers were suitable for developing nicotine transdermal patches with the composition of 4%,1.4%,0.5%and 0.8%of Eudragit E100,HPMC E5,PEG4000 and PVP K30,respectively.

Fig.1–Skin adhesion of selected patch(a)and drug release profle(b):Eudragit E100 4%(Formula A),Eudragit E100 10% (Formula B),Eudragit L100 4%(Formula C),Eudragit L100 4%(Formula D).

Acknowledgement

The researchers would like to express our sincere thanks to Thailand Center of Excellence on Life Sciences(TCELS)for supporting throughout the course of this research work.

R E F E R E N C E S

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[3]Gore AV,Chien YW.The nicotine transdermal system.Clin Dermatol 1998;16:599–615.

*E-mail address:petedanaipat@gmail.com.

Peer review under responsibility of Shenyang Pharmaceutical University.

http://dx.doi.org/10.1016/j.ajps.2015.11.033

1818-0876/©2016 Production and hosting by Elsevier B.V.on behalf of Shenyang Pharmaceutical University.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).