Dendroforin inhibits lung cancer cell migration

b,Pithi Chanvorahoteb

aDepartment of Pharmacology and Physiology,Faculty of Pharmaceutical Sciences,Chulalongkorn University, Bangkok 10330,Thailand

bCell-Based Drug and Health Product Development Research Unit,Faculty of Pharmaceutical Sciences, Chulalongkorn University,Bangkok 10330,Thailand

cDepartment of Pharmacognosy and Pharmaceutical Botany,Faculty of Pharmaceutical Sciences, Chulalongkorn University,Bangkok 10330,Thailand

Dendroforin inhibits lung cancer cell migration

Kesarin Busaranona,*,Varisa Pongrakhananona,b, Boonchoo Sritularakc,Pithi Chanvorachotea,b

aDepartment of Pharmacology and Physiology,Faculty of Pharmaceutical Sciences,Chulalongkorn University, Bangkok 10330,Thailand

bCell-Based Drug and Health Product Development Research Unit,Faculty of Pharmaceutical Sciences, Chulalongkorn University,Bangkok 10330,Thailand

cDepartment of Pharmacognosy and Pharmaceutical Botany,Faculty of Pharmaceutical Sciences, Chulalongkorn University,Bangkok 10330,Thailand

A R T I C L E I N F O

Article history:

Available online 25 November 2015

Dendroforin

Antimigration

H460

Lung cancer

Lung cancer patients have high mortality rate due to the high incidence rate of metastasis.To achieve metastasize,cancer cells require an ability to migrate from initial to secondary site.Therefore,the promising compound with antimigrating effect might be a beneft for cancer metastasis[1].Dendroforin,a potential active polyphenol compound,is extracted from Dendrobium brymerianum found in Thailand,Burma,Laos,and China.Previous studies showed that some Dendrobium species exhibit the potential sources of cytotoxic compounds[2,3].Dendroforin has been identifed from this plant and investigated for cytotoxic and antimigratory activities in this study.The results showed that dendroforin has signifcant cytotoxic effect against human lung cancer H460 cells,showing 80%inhibition at a concentration of 15 μg/mL(IC50=124.77±3.63 μg/mL).Additionally,wound healing assay reveals that dendroforin is able to suppress lung cancer migration.This study suggests that dendroforin might be a potential compound for attenuation of lung cancer metastasis.

Acknowledgements

This research was funded by the Ratchadapiseksompoch Endowment Fund(2014),Chulalongkorn University(CU-57-003-HR).

Fig.1–Effects of Dendroforin on(A)H460 cell viability,(B)H460 cell migration,and(C)relative wound space.

R E F E R E N C E S

[1]Eccles SA,Welch DR.Metastasis:recent discoveries and novel treatment strategies.Lancet 2007;369:1742–1757.

[2]Yau L,Tzi BN,Ren MY,et al.Evaluation of chemical constituents and important mechanism of pharmacological biology in Dendrobium plants.Evid Based Complement Alternat Med 2015;2015:841752.doi:10.1155/2015/ 841752.

[3]Pengpaeng P,Sritularak B,Chanvorachote P.Dendrofalconerol A sensitizes anoikis and inhibits migration in lung cancer cell.J Nat Med 2015;69:178–190.

*E-mail address:keasrinb@gmail.com.

Peer review under responsibility of Shenyang Pharmaceutical University.

http://dx.doi.org/10.1016/j.ajps.2015.11.049

1818-0876/©2016 Production and hosting by Elsevier B.V.on behalf of Shenyang Pharmaceutical University.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).