Evaluation of blank flm forming polymeric dispersions based on Eudragit RL 30D and RS 30D for transdermal drug delivery

b

aThe Herbal Medicinal Products Research and Development Center,Faculty of Pharmacy,Rangsit University, Pathum Thani 12000,Thailand

bDepartment of Pharmaceutical Chemistry,Faculty of Pharmacy,Rangsit University,Pathum Thani 12000, Thailand

Evaluation of blank flm forming polymeric dispersions based on Eudragit RL 30D and RS 30D for transdermal drug delivery

Chaowalit Montona,*,Jirapornchai Suksaereea,b

aThe Herbal Medicinal Products Research and Development Center,Faculty of Pharmacy,Rangsit University, Pathum Thani 12000,Thailand

bDepartment of Pharmaceutical Chemistry,Faculty of Pharmacy,Rangsit University,Pathum Thani 12000, Thailand

A R T I C L E I N F O

Article history:

Available online 24 November 2015

Film forming polymeric dispersions Eudragit

Transdermal drug delivery

The frst approved transdermal drug delivery system in the United States in 1979 is a scopolamine patch for treatment of motion sickness.Transdermal drug delivery system has many advantages over oral route such as it is useful for vomiting and unconscious patients.It can avoid frst pass metabolism by the liver.It is non-invasive way and self-administered system compared to injections.The flm forming polymeric solutions are a novel transdermal drug delivery system.This system consists of an active drug,flm forming polymer,plasticizer,and other excipients.The flm forming polymeric solutions as a liquid form are frstly applied to the skin,and then the solvent is evaporated from their formulation formed the in situ flm that adhere on the skin[1,2].

The aim of this study was to prepare and evaluate of the blank flm forming polymeric dispersions based on Eudragit RL 30D and RS 30D.Film forming polymeric dispersions were prepared by the simple blending method[3].The formulation factors;amount of absolute ethanol(solvent),amount of glycerin(plasticizer),and ratio of Eudragit RL 30D and RS 30D(flm forming polymer)were studied.Five parameters including pH, viscosity,spreadability,drying time of flm formation,and integrity of flm on skin were evaluated.Results showed that all formulas were a homogeneous appearance(Fig.1a).Increasing of absolute ethanol from 0 to 24.4%w/w,pH and spreadability of the formulations were slightly increased,while,viscosity was not affected.Increasing of glycerin from 2.4 to 16.7%w/w,pH was not affected,viscosity decreased,while,spreadability increased.This result was similar to the varying of ratio between Eudragit RL 30D and RS 30D from 30:0 to 0:30.After application of the formulation to the skin,all formulas that contained glycerin(13.0 and 16.7%w/w)and absolute ethanol(20.8 and 21.7%w/w)provided complete flm,while,low content of glycerin and absolute ethanol caused flm cracking(Fig.1b).This result indicated that plasticizer played an important role on flm characteristics.Furthermore,all formulations dried within 15 minutes after these were applied to the skin of theresearcher.In conclusion,these flm forming polymeric dispersions had good properties that possibly act as a base formula for transdermal drug delivery.Moreover,drug loaded flm forming polymeric dispersions will be further investigated.

Fig.1–(a)Physical appearance of blank flm forming polymeric dispersions prepared from different ratios of Eudragit RL 30D and RS 30D,and(b)crack flm and complete flm characteristic after applied to the skin.

Acknowledgements

The authors would like to thank the Faculty of Pharmacy, Rangsit University,Thailand for fnancial and facilities support. We also greatly appreciated to the Jebsen and Jessen Nutri Life Ltd.,Thailand for supporting some chemicals in this study.

R E F E R E N C E S

[1]Pichayakorn W,Suksaeree J,Boonme P,et al.Deproteinized natural rubber flm forming polymeric solutions for nicotine transdermal delivery.Pharm Dev Technol 2013;18:1111–1121.

[2]Zurdo Schroeder I,Franke P,Schaefer UF,et al.Delivery of ethinylestradiol from flm forming polymeric solutions across human epidermis in vitro and in vivo in pigs.J Control Release 2007;118:196–203.

[3]Pichayakorn W,Suksaeree J,Boonme P,et al.Transdermal nicotine mixed natural rubber-hydroxypropylmethylcellulose flm forming systems for smoking cessation:in vitro evaluations.Pharm Dev Technol 2015;20:966–975.

*E-mail address:chaowalit@rsu.ac.th.

Peer review under responsibility of Shenyang Pharmaceutical University.

http://dx.doi.org/10.1016/j.ajps.2015.11.109

1818-0876/©2016 Production and hosting by Elsevier B.V.on behalf of Shenyang Pharmaceutical University.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).