不饱和烃高效转化中的新催化体系研究

王从洋

摘 要：催化剂在现代有机反应中占核心地位，众多知名反应的发现和发展都以新催化剂和催化体系的发现为基础。随着经济社会可持续发展对化学提出越来越高的要求，围绕不饱和烃催化转化反应在催化效率、选择性、原子经济性和实用性等各个方面都面临着巨大挑战。因此，迫切需要针对存在的挑战性难题发展新型的催化剂和催化体系。催化剂的种类繁多，不同类反应（甚至不同底物的同类反应）对催化剂的结构都有不同的要求，因此，催化剂的结构创新，发展结构可调的催化剂，特别是有一定优势结构的催化剂是不饱和烃高效转化的关键问题。同时催化剂的创新性运用，如，多种催化剂的协同作用，对反应的优化和新反应的发现也有重要意义。

关键词：不饱和烃 不对称催化 催化剂 全合成

Abstract： Catalysts play an essential role in modern organic syntheses and green chemistry， which is the key basis for the discovery and evolution of a wide range of name reactions. The expectation of sustainable chemistry poses great challenges for the transformations of unsaturated hydrocarbons in terms of the efficiency of catalysis， reaction selectivities， atom economy， and the applicability of reactions， among others. Therefore， the development of new types of catalytic systems to meet these challenges is highly desirable. Due to the variety of reactions relies mainly on the structures of catalysts， the design and development of novel catalysts with easily tunable structure is the key for high efficient transformations of unsaturated hydrocarbons. Moreover， the implication of multiple catalysts to generate a synergic effect has also great importance to explore for new reactions. In the past two years， we have developed a series of highly efficient chiral catalysts marked with our specialty， such as bioinspired-primary-amine catalysts， N-heterocyclic carbine catalysts， supermolecular catalysts， and so on. Furthermore， a plethora of new reactions and the total syntheses of important natural products were achieved. As a result， 59 SCI publications were obtained and 11 patents were applied.

Key Words： Unsaturated hydrocarbons； Asymmetric catalysis； Catalysts； Total syntheses

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