外周血Th17和调节性T细胞变化与患儿支气管哮喘活动状态的相关性研究

2015-02-21 06:08陈啸洪李华浚姚欢银张佩红章杭湖刘小群周国中
中国全科医学 2015年8期
关键词:调节性绍兴市儿科

陈啸洪,李华浚,姚欢银,朱 芹,张佩红,章杭湖,刘小群,周国中



·短篇论著·

陈啸洪,李华浚,姚欢银,朱 芹,张佩红,章杭湖,刘小群,周国中

哮喘;T淋巴细胞,辅助诱导;T淋巴细胞,调节性;儿童

表1 三组外周血检测指标比较

注:与慢性持续期组比较,*P<0.05

1 对象与方法

1.1 纳入标准与排除标准 纳入标准:(1)年龄5~14 岁;(2)符合中华医学会儿科学分会呼吸学组制定的《儿童支气管哮喘诊断与防治指南》的诊断标准[7]。排除标准:(1)合并其他肺部疾病者;(2)合并严重心、肝、肾等疾病者。

1.2 研究对象 选择2010 年1月—2013年12月在绍兴市人民医院儿科哮喘专病门诊就诊及住院的98例支气管哮喘患儿作为慢性持续期组,其中男50例,女48例;年龄5 ~14岁,平均(8.9±2.2)岁;轻度47例,中度43例,重度8例。选择同期在本院治疗的40例缓解期支气管哮喘患儿为缓解期组,其中男21例,女19例;年龄6~14岁,平均(8.6±1.9)岁。另选择同期在本院儿童保健门诊体检健康的儿童40例作为健康对照组,其中男22例,女18例;年龄6~14岁,平均(8.1±1.2)岁。3组性别、年龄比较,差异无统计学意义(χ2=0.182,F=2.074,P>0.05)。

2 结果

3 讨论

[1]周虹,文富强.影响支气管哮喘Th1/Th2失衡的因素及治疗的新视点[J].中华哮喘杂志:电子版,2009,3(4):303-306.

[2]Wiethe C,Debus A,Mohrs M,et al.Dendritic cell differentiation state and their interaction with NK T cells determine Th1/Th2 differentiation in the murine model of Leishmania major infection[J].J Immunol,2008,180(7):4371-4381.

[3]Douwes J,Gibson P,Pekkanen J,et al.Non-eosinophilic asthma:importance and possible mechanisms[J].Thorax,2002,57(7):643-648.

[4]Tian BP,Shen HH.Interleukin-17A and its role in bronchial asthma[J].Chinese Journal of Asthma :Electronic Version,2013,7(5):350-355.(in Chinese) 田宝平,沈华浩.白介素17A及其在支气管哮喘中的作用[J].中华哮喘杂志:电子版,2013,7(5):350-355.

[5]Zhou C,Chen JH,Yin KS.The Th17/Treg imbalance in the pathogenesis of asthma in a mouse model[J].Chinese Journal of Respiratory and Critical Care Medicine,2010,9(1):28-31.(in Chinese) 周辰,陈军浩,殷凯生.辅助性T细胞17和调节性T细胞在哮喘小鼠中失衡表达及其意义[J].中国呼吸与危重监护杂志,2010,9(1):28-31.

[6]Shi YH,Shi GC,Wan HY,et al.Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with allergic asthma[J].Chin Med J(Engl),2011,124(13):195l-1956.

[7]The Subspecialty Group of Respiratory Diseases,the Society of Pediatrics,Chinese Medical Association,the Editorial Board,Chinese Journal of Pediatrtics.Guideline for the Diagnosis and Optimal Management of Asthma in Children[J].Chinese Journal of Pediatrics,2008,46(10):745-753.(in Chinese) 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745-753.

[8]Cosmi L,Liotta F,Maggi E,et al.Th17 cell:new players in asthma pathogenesis[J].J Allergy Clin Immunol,2011,66(8):989-998.

[9]Chen JM,Li YL,Huang P,et al.Effect of budesonide on the balance of Th17/Treg for patients with bronchial asthma[J].International Journal of Respiratio,2011,32(18):1378-1382.(in Chinese) 陈济明,李一禄,黄平,等.布地奈德对支气管哮喘患者Th17/Treg平衡的干预机制研究[J].国际呼吸杂志,2011,32(18):1378-1382.

[10]Li HJ,Peng S,Liang P,et al.Changes of T helper lymphocyte 17,interleukin-17,interleukin-21 levels of peripheral blood in children with asthma[J].Journal of Applied Clinical Pediatrics,2011,26(9):692-694.(in Chinese) 李会娟,彭韶,梁鹏,等.支气管哮喘患儿外周血辅助性T淋巴细胞17、白细胞介素-17、白细胞介素-21水平变化[J].实用儿科临床杂志,2011,26(9):692-694.

[13]Yang YL,Pan YQ,He BS,et al.Changes of regulatory T cells and T helper cells in peripheral blood and their roles in the severity evaluation in children with asthma[J].Chinese Journal of Contemporary Pediatrics,2011,13(6):482-485.(in Chinese) 阳艳丽,潘玉琴,何帮顺,等.哮喘患儿外周血调节性T细胞和Th1/Th2的变化及其与哮喘病情的关系[J].中国当代儿科杂志,2011,13(6):482-485.

[14]Toldi G,Molvarec A,Stencxer B,et al.Peripheral T(h)1/T(h)2/T(h)17/regulatory T-cell balance in asthmatic pregnancy[J].Int Immunol,2011,23(11):669-677.

[15]Palomares O,Yaman G,Azkur AK,et al.Role of Treg in immune regulation of allergic diseases[J].Eur J Immunol,2010,40(5):1232-1240.

修回日期:2014-11-05)

(本文编辑:吴立波)

CHEN Xiao-hong,LI Hua-jun,YAO Huan-yin,et al.

Department of Pediatrics Medicine,Shaoxing People's Hospital,Shaoxing 312000,China

Asthma;T-lymphocytes,helper-inducer;T-lymphocytes,regulatory;Child

绍兴市科技计划项目(2012B70069)

312000浙江省绍兴市人民医院儿内科(陈啸洪,李华浚,姚欢银,朱芹,张佩红,章杭湖,刘小群),临床检验中心(周国中)

陈啸洪,312000浙江省绍兴市人民医院儿内科; E-mail:cxh00869@163.com

R 725.622.5

B

10.3969/j.issn.1007-9572.2015.08.028

2014-09-28;

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