小儿热速清糖浆治疗手足口病患儿的临床效果

陈海华

[关键词] 手足口病;常规治疗;小儿热速清糖浆;皮疹消失时间;退热时间

[中图分类号] R725.1          [文献标识码] B          [文章编号] 1673-9701（2021）25-0143-04

Clinical effect of Xiaoer Resuqing syrup on children with hand-foot-mouth disease

CHEN Haihua

Department of Pediatrics， Huai′an Maternal and Child Health Hospital，Huai′an   223001，China

[Abstract] Objective To explore the clinical effect of Xiaoer Resuqing syrup in children with hand-foot-mouth disease. Methods A total of 100 children with hand-foot-mouth disease admitted to our hospital from September 2019 to September 2020 were selected and divided into the observation group （Xiaoer Resuqing syrup combined with conventional treatment， n=50） and the control group （conventional treatment， n=50） according to different treatment regimens. The clinical effect，disappearance time of clinical symptoms，C-reactive protein （CRP） level，and procalcitonin （PCT） level were recorded and compared between the two groups. Results The clinical treatment effect of the observation group was 98.0%，which was better than 76.0% of the control group， and the difference was significant （P<0.05）.The disappearance time of clinical symptoms of fever， mouth pain， rash， and anorexia in the observation group （[1.57±0.45] d， [3.14±0.71] d， [4.01±1.04] d， [1.91±0.61] d） was shorter than that in the control group （[3.71±0.67] d， [5.02±0.86] d， [5.64±1.26] d， [3.65±0.81] d）， and the difference was significant （P<0.001）. The levels of CRP and PCT in the observation group after treatment （[1.16±0.21] mg/L， [0.31±0.06] ng/mL） were lower than those in the control group （[2.32±0.39] mg/L， [0.56±0.08] ng/mL） （P<0.001）. Conclusion Xiaoer Resuqing syrup in the treatment of Children with hand-foot-mouth disease has a significant clinical therapeutic effect，which makes the disappearance time of clinical symptoms in children shorter， and the contents of CRP and PCT in children effectively reduced， which had more application value.

[Key words] Hand-foot-mouth disease; Conventional treatment; Xiaoer Resuqing syrup; Time of rash disappearance; Antipyretic time

手足口病属于常见小儿疾病，多因肠道病毒诱发疾病[1]，临床上常以柯萨奇病毒A16型（Coxsachie virus，Cox16）和肠道病毒71型（Enterovirus 71，EV71）最为常见[2]。该病多发于学龄前儿童，多為5岁及以下的儿童，主要是因为儿童年龄尚小，机体免疫功能尚未发育完善，对于病毒的抵抗能力还不够强，所以肠道病毒入侵后，容易形成疾病[3]。患儿发病后，会有厌食、口痛、发热、口腔疱疹或是手足疱疹等症状。若患儿病情较轻，一周内便可自愈。若患儿病情较重，则需及时进行有效治疗，预防疾病恶化，诱发心肺、神经系统并发症，如心肌炎、肺水肿等[4]。同时由于其传播途径较为复杂，传播速度较快，导致其临床控制难度较大[5]。因此临床中探索有效实用的治疗方法十分重要。中药治疗小儿手足口病取得了较好疗效，但传统煎剂汤药口感苦，且剂量大，家长喂服困难，患儿配合程度低。小儿热速清糖浆是一种中药糖浆制剂，口感甘甜，患儿易接受。本研究探讨小儿热速清糖浆对手足口病患儿的临床效果，以寻求更优的临床治疗方法。