叶酸联合维生素B6治疗缺血性脑卒中相关血清指标观察及疗效分析

孙亚男　　孙红霞　　姜爽　　郑敏　　朱兆武

[摘要] 目的 探讨常规治疗与叶酸联合维生素B6治疗缺血性脑卒中疗效及对相关血清指标的影响。 方法 采集2020年1—10月我院缺血性脑卒中患者450例，通过随机数字法分为对照组（常规治疗）与研究组（叶酸联合维生素B6），每组各225例。比较两组治疗前后NIHSS评分及mRS评分、治疗效果、生化指标、治疗后D-二聚体、TG、LDL-C、TC、Hcy、HDL-C等指标。 结果 两组治疗前NIHSS评分及mRS评分比较，差异无统计学意义（P>0.05）;研究组治疗后NIHSS评分[（4.77±2.19）分]与mRS评分[（3.01±0.54）分]均低于对照组，差异有统计学意义（P<0.05）。研究组治疗后总有效率（94.7%）高于对照组（80.4%），差异有统计学意义（P<0.05）。两组治疗前各项生化指标水平比较，差异无统计学意义（P>0.05）;研究组治疗后D-二聚体（2.11±0.39）μg/L、TG（3.46±0.33）mmol/L、LDL-C（1.39±0.20）mmol/L、TC（1.51±0.31）mmol/L、Hcy（1.31±0.20）μmol/L水平均低于对照组，HDL-C[（1.31±0.20）mmol/L]水平高于對照组，差异有统计学意义（P<0.05）。 结论 在缺血性脑卒中治疗中，更推荐采用叶酸联合维生素B6治疗，可减轻神经功能受损程度，改善D-二聚体与Hcy水平，使血脂水平得到有效调整，整体治疗效果明确。

[关键词] 常规治疗;叶酸;维生素B6;缺血性脑卒中;血清指标

[中图分类号] R743.1          [文献标识码] B          [文章编号] 1673-9701（2021）20-0058-04

Observation and efficacy analysis on the folic acid combined with Vitamin B6 in the treatment of ischemic stroke related serum index

SUN Ya′nan   SUN Hongxia   JIANG Shuang   ZHENG Min   ZHU Zhaowu

No.1 Department of Encephalopathy，Jiamusi Traditional Chinese Medicine Hospital in Heilongjiang Province， Jiamusi 154000， China

[Abstract] Objective To explore the curative effect of conventional treatment and folic acid combined with vitamin B6 in the treatment of ischemic stroke and its effects on related serum indices. Methods From January 2020 to October 2020，a total of 450 patients with ischemic stroke in our hospital were collected. They were divided into a control group of 225 cases （conventional treatment） and a study group of 225 cases （folic acid combined with vitamin B6） by random number method. The NIHSS score and mRS score before and after treatment， curative effect， biochemical indices， D-dimer， TG， LDL-C， TC， Hcy， and HDL-C after treatment of two groups were compared. Results The difference between the NIHSS score and mRS score before treatment between the two groups was small and not statistically significant（P>0.05）; compared with the control group， the NIHSS score （4.77±2.19） points and mRS score （3.01±0.54） points in the study group after treatment were lower， and the difference was large and statistically significant（P<0.05）. Compared with the control group（80.4%）， the total effective rate after treatment in the study group was 94.7%， and the difference was large and statistically significant（P<0.05）. The differences in the levels of various biochemical indicators between the two groups before treatment were small and not statistically significant（P>0.05）; compared with the control group， the D-dimer （2.11±0.39）μg/L， TG（3.46±0.33）mmol/L， LDL-C（1.39±0.20）mmol/L， TC （1.51±0.31）mmol/L，and Hcy （1.31±0.20）μmol/L after treatment were lower， and the level of HDL-C（1.31±0.20）mmol/L was higher. The differences were statistically significant（P<0.05）. Conclusion In the treatment of ischemic stroke， folic acid combined with vitamin B6 therapy is more recommended， which can reduce the degree of neurological impairment，improve the level of D-dimer and Hcy， and effectively adjust the blood lipid level.The overall therapeutic effect is exact.