来曲唑结合地塞米松对多囊卵巢综合征患者血清MCP-1、AMH水平及妊娠率的影响

金雁　肖新益

【摘要】 目的：探讨来曲唑结合地塞米松对多囊卵巢综合征（PCOS）患者血清单核细胞趋化蛋白（MCP-1）、抗苗勒管激素（AMH）水平及妊娠率的影响。方法：选择2015年12月-2018年5月在笔者所在医院就诊的PCOS患者86例，根据盲抽法将其分为两组，各43例。对照组采用来曲唑治疗，在此基础上，观察组采用地塞米松片治疗，对比两组雌激素水平、妊娠情况、血清MCP-1、AMH水平。结果：治疗后两组黄体生成激素、睾酮均低于治疗前，且观察组均低于对照组，差异均有统计学意义（P<0.05）;观察组妊娠率（48.84%）高于对照组（23.26%），差异有统计学意义（P<0.05）;治疗后两组MCP-1、AMH水平均低于治疗前，且观察组均低于对照组，差异均有统计学意义（P<0.05）。结论：来曲唑结合地塞米松可有效降低PCOS患者雌激素水平，调节血清MCP-1、AMH水平，提高妊娠率。

【关键词】 多囊卵巢综合征 地塞米松 来曲唑 单核细胞趋化蛋白-1 抗苗勒管激素 妊娠率

doi：10.14033/j.cnki.cfmr.2020.15.056 文献标识码 B 文章编号 1674-6805（2020）15-0-02

The Effect of Letrozole Combined with Dexamethasone on Serum MCP-1 and AMH in Patients with Polycystic Ovary Syndrome and Pregnancy Rate/JIN Yan， XIAO Xinyi. //Chinese and Foreign Medical Research， 2020， 18（15）： -135

[Abstract] Objective： To investigate the effect of Letrozole combined with Dexamethasone on serum monocyte chemoattractant protein （MCP-1）， anti Mullerian hormone （AMH） and pregnancy rate in patients with polycystic ovary syndrome （PCOS）. Method： A total of 86 patients with PCOS who were treated in our hospital from December 2015 to May 2018 were selected and divided into two groups according to blind sampling method， 43 in each group. The control group was treated with Letrozole， on this basis， the observation group was treated with Dexamethasone Tablets， and the estrogen level， pregnancy situation， serum MCP-1， AMH level of the two groups were compared. Result： After treatment， the luteinizing hormone and testosterone in the two groups were lower than those before treatment， and the observation group was lower than the the control group， the differences were statistically significant （P<0.05）. The pregnancy rate in the observation group （48.84%） was higher than that in the control group （23.26%）， the difference was statistically significant （P<0.05）. The levels of MCP-1 and AMH in the two groups after treatment were lower than those before treatment， and the observation group were lower than the control group， the differences were statistically significant （P<0.05）. Conclusion： Letrozole combined with Dexamethasone can effectively reduce the estrogen level of PCOS patients， regulate the serum MCP-1 and AMH levels， and improve the pregnancy rate.

[Key words] Polycystic ovary syndrome Dexamethasone Letrozole Monocyte chemoattractant protein-1 Against Mullerian hormone Pregnancy rate

First-authors address： Huangshi Aikang Hospital， Huangshi 435000， China

多囊卵巢綜合征（PCOS）是常见的女性内分泌代谢异常疾病之一，以慢性无排卵和高雄激素血症为特征，主要临床表现为月经周期不规律、不孕等[1-2]。现在对于多囊卵巢综合征，手术治疗已经不是第一线治疗方法，多数通过药物治疗，都顺利怀孕，是很多患者治疗的目的[3]。来曲唑是一个芳香化酶抑制剂，芳香化酶可催化女性身体内雄激素，从而抑制身体里面雄激素转化为雌激素。有研究发现，联合地塞米松使用可更有效地促进排卵，提高妊娠率[4]。鉴于此，本研究主要探讨来曲唑结合地塞米松对PCOS患者血清单核细胞趋化蛋白（MCP-1）、抗苗勒管激素（AMH）水平及妊娠率的影响，现报道如下。