吴孟超院士简介

吴孟超，中国科学院院士，2005年度国家最高科学技术进步奖获得者，我国肝癌研究的开创人之一，生于福建闽清县，1940年自马来西亚归国。吴教授1949年毕业于同济大学医学院。他是海军军医大学(原第二军医大学)一级教授，博士生导师，一位杰出的医学科学家，中国肝胆外科的主要奠基人之一。

吴教授提出了“五叶四段”的肝解剖学理论; 建立了“常温下间歇肝门阻断止血技术”，提供了纠正肝癌术后常见的致命性生化代谢紊乱的新策略; 提出了“二期手术”的概念，为晚期肝癌开辟了一条新的治疗途径。

吴教授组建了国际上大规模的肝脏外科专业研究所，牵头指导了一系列具有国际先进水平的基础研究工作，研制了细胞融合和双特异性单抗修饰两种肿瘤疫苗，发明了携带抗癌基因的增殖性病毒载体等，研究结果发表在《科学》《自然医学》《肝病学》《癌基因》等杂志上。

至今，吴孟超院士仍然致力于肝癌发病机制及肝癌医治方略的研究当中。

Introduction to Academician WU Mengchao

Wu Mengchao, academician of the Chinese Academy of Sciences, winner of the National Award of Science and Technology of China in 2005, a pioneer in Chinese liver cancer research, was an overseas Chinese born in Minqing County, Fujian Province, and returned from Malaysia in 1940. Prof. Wu graduated from Tongji University School of Medicine in 1949. He is grade-one professor and PhD supervisor of the Navy Medical University (formerly Second Military Medical University), and is known as the major founder of liver surgery in China and an outstanding scientist of medicine.

Prof. Wu proposed the anatomic idea of “five lobes and four segments”. To solve the challenging problem of hemorrhage in liver operations, he created the technique of “intermittent occlusion of porta hepatis in normothermic condition”. He set up a series of new strategies for correcting fatal disturbance of biochemical metabolism occurring perioperatively. He raised the concept of “two-stage operation”, which opened up a new approach to the treatment of late-stage liver cancer.

Prof. Wu has developed the current world’s medical center of hepatobiliary surgery, and has been leading a series of basic studies of the world up-to-date level, including biopathologic study on liver cancer. His team also developed two vaccines, that is cell fusion vaccine and bi-specific monoclonal antibody modified vaccine, and created proliferative virus vectors carrying anti-cancer gene. The results of these studies are published inScience,Nature Medicine, Hepatology, Oncogene, etc.

Today, academician Wu Mengchao remains active in clinic and basic research of liver cancer, developing effective therapeutic strategies and investigating mechanisms of hepatocarcinogenesis.

封面人物：中国科学院院士——吴孟超