HMGB1、MMP-9及VEGF-C在老年肺癌患者组织中水平变化及意义研究

孙党泽 张潍

[摘要] 目的 探讨HMGB1、MMP-9及VEGF-C在老年肺癌患者组织中的水平变化及意义。方法 方便选取2018年1月—2019年3月该院收治的60例老年肺癌患者和36例癌旁组织（距肺癌病灶2 cm）标本作为研究对象，比較两组患者HMGB1、MMP-9、VEGF-C阳性表达情况，并探讨肺癌组织中HMGB1、MMP-9及VEGF-C表达与临床病理特征的关系。结果 肺癌组患者HMGB1、MMP-9及VEGF-C阳性表达率（63.3%、70.0%、66.7%）显著高于癌旁组（31.4%、28.6%、0.0%），差异有统计学意义（χ2=13.046、9.259、5.392，P<0.05）;肺癌组织中HMGB1、MMP-9、VEGF-C表达与性别、年龄、分化程度无关，差异无统计学意义（P>0.05）;腺癌、有淋巴结转移的HMGB1、MMP-9、VEGF-C阳性表达率（76.5%、79.4%、82.4%;85.7%、89.3%、82.1%）显著高于鳞癌、无淋巴结转移（50.0%、26.9%、50.0%;46.9%、56.3%、53.1%），差异有统计学意义（χ2=7.126、5.336、4.825、10.392、3.503、5.177，P<0.05）。 结论 肺癌组患者HMGB1、MMP-9及VEGF-C阳性表达率均显著高于癌旁组，肺癌组织中HMGB1、MMP-9、VEGF-C阳性表达与组织学分型和无淋巴结转移有关。

[关键词] 肺癌; 高迁移率族蛋白B1; 基质金属蛋白酶-9; 血管内皮生长因子-C

[Abstract] Objective To investigate the changes and significance of HMGB1， MMP-9 and vascular endothelial growth factor-C in elderly patients with lung cancer. Methods From January 2018 to March 2019， 60 elderly patients with lung cancer and 36 adjacent tissues （2 cm away from the lesion of lung cancer） were convenient selected as the study subjects. The positive expression of HMGB1， MMP-9 and VEGF-C in the two groups were compared， and the relationship between the expression of HMGB1， MMP-9 and VEGF-C in lung cancer tissues and clinicopathological characteristics was discussed. Results The positive expression rates of HMGB1， MMP-9 and VEGF-C in lung cancer group （63.3%， 70.0%， 66.7%） were significantly higher than those in para-cancer group （31.4%， 28.6%， 0.0%），the difference was statistically significant（χ2=13.046， 9.259， 5.392， P<0.05）; the expressions of HMGB1， MMP-9 and VEGF-C in lung cancer tissues were not related to sex， age and differentiation degree，the difference was notstatistically significant （P>0.05）; the positive expression rates of HMGB1， MMP-9 and VEGF-C in adenocarcinoma， lymph node metastasis （76.5%， 79.4%， 82.4%; 85.7%， 89.3%， 82.1%） were significantly higher than those of squamous cell carcinoma and non-lymph node metastasis （50.0%， 26.9%， 50.0%; 46.9%， 56.3%， 53.1%），the difference was statistically significant（χ2=7.126， 5.336， 4.825， 10.392， 3.503， 5.177， P<0.05）. Conclusion The positive expression rates of HMGB1， MMP-9 and VEGF-C in lung cancer group were significantly higher than those in adjacent group. The positive expression rates of HMGB1， MMP-9 and VEGF-C in lung cancer tissue were related to histological classification and lymph node metastasis.

[Key words] Lung cancer; High mobility group protein B1; Matrix metalloproteinase-9; Vascular endothelial growth factor-C