探讨氨氯地平联合厄贝沙坦对糖尿病合并高血压的疗效及对QT离散度的影响

刘涛

[摘要] 目的 对糖尿病合并高血压患者接受氨氯地平联合厄贝沙坦治疗的效果进行分析研究，探讨其对QT离散度的影响情况，为临床提供依据。 方法 2015年2月—2017年2月该院对104例糖尿病合并高血压患者开展分析，分成ABC 3组，A组34例患者使用厄贝沙坦治疗，B组患者34例使用氨氯地平治疗，C组患者36例使用厄贝沙坦和氨氯地平治疗，对3组的临床治疗效果进行对比分析。结果 A组的临床有效率是82.35%，B组的临床治疗有效率是88.24%，C组的临床治疗有效率是100.00%，3组结果差异有统计学意义（P<0.05），AB两组差异无统计学意义（P>0.05）。3組血糖和血压均改善，C组比其他两组优秀，A组比B组优秀，结果差异有统计学意义（P<0.05）。3组的QT期间，校正QT期间，QT期间离散度等指标对比在治疗前没有差异性，治疗后，C组比其他两组低，结果差异有统计学意义（P<0.05）。结论 糖尿病合并高血压使用氨氯地平联合厄贝沙坦治疗的效果突出，患者的血压和血糖稳定，心室肥厚情况得到了改善，临床中应该进行推广使用。

[关键词] 氨氯地平;厄贝沙坦;糖尿病;高血压;QT离散度

[中图分类号] R544.1          [文献标识码] A          [文章编号] 1672-4062（2019）09（a）-0067-02

[Abstract] Objective To study the effect of amlodipine combined with irbesartan on QT dispersion in patients with diabetes mellitus and hypertension， and to provide evidence for clinical practice. Methods From February 2015 to February 2017， 104 patients with diabetes mellitus and hypertension were analyzed in our hospital. They were divided into three groups： ABC group， 34 patients in group A were treated with irbesartan， 34 patients in group B were treated with amlodipine， and 36 patients in group C were treated with irbesartan and amlodipine. Results  The clinical effective rate of group A was 82.35%， that of group B was 88.24%， and that of group C was 100.00%. There were statistical differences among the three groups（P<0.05）. There was no statistically significant difference between the two groups（P>0.05）. The blood sugar and blood pressure of the three groups were improved. Group C was better than the other two groups， and Group B was better than Group A. There was statistical difference in the results（P<0.05）. There was no statistically significant difference between the three groups in terms of QT interval， corrected QT interval dispersion and other indicators before treatment. After treatment， group C was lower than the other two groups， and the results were statistically significant different（P<0.05）. Conclusion Amlodipine combined with irbesartan is effective in the treatment of diabetes mellitus complicated with hypertension. Blood pressure and blood sugar are stable， and ventricular hypertrophy is improved. It should be popularized in clinic.

[Key words] Amlodipine; Irbesartan; Diabetes mellitus; Hypertension; QT dispersion

糖尿病和高血压是比较多见的疾病，治疗难度大[1]。药物治疗能够有效的改善患者的血糖水平，降低血压，氨氯地平和厄贝沙坦联合治疗的效果突出，受到了广泛的关注[2]。此次该院于2015年2月—2017年2月选取了104例糖尿病合并高血压患者开展分析，将患者分成3组进行对比，现根据研究开展以下报道。