门冬氨酸鸟氨酸联合乳果糖治疗肝性脑病患者的效果观察

宋方敏　李丹　王良

【摘要】 目的：觀察门冬氨酸鸟氨酸联合乳果糖治疗肝性脑病（patients encephalopathy，HE）患者的临床效果。方法：72例HE患者根据数字表法随机分为两组，两组入院后均予以综合措施治疗，对照组（36例）在此基础上加用门冬氨酸鸟氨酸治疗，观察组（36例）在对照组基础上加用乳果糖治疗，两组患者均连续治疗14 d。比较两组患者治疗总有效率，检测两组患者治疗前后谷丙转氨酶（ALT）、总胆红素（TBIL）及血氨等表达水平变化，采用数字连接试验（NCT）与数字符号试验（DST）评估两组患者治疗前后认知功能状态。结果：观察组患者治疗总有效率（88.89%）明显高于对照组（66.67%），差异有统计学意义（P<0.05）;两组患者治疗前ALT、TBIL及血氨水平比较差异无统计学意义（P>0.05），两组患者治疗后ALT、TBIL及血氨水平明显降低（P<0.05），且观察组治疗后低于对照组（P<0.05）;两组患者治疗前NCT时间、DST评分比较差异无统计学意义（P>0.05），两组患者治疗后NCT时间明显缩短，DST评分明显升高（P<0.05），且观察组治疗后优于对照组 （P<0.05）。结论：门冬氨酸鸟氨酸联合乳果糖治疗HE患者疗效显著，不但可改善肝功能和降低血氨水平，还可改善患者认知功能。

【关键词】 门冬氨酸鸟氨酸; 乳果糖; 肝性脑病

doi：10.14033/j.cnki.cfmr.2019.19.007 文献标识码 B 文章编号 1674-6805（2019）19-00-03

Clinical Observation of Nmda Ornithine Combined with Lactulose on the Treatment of Patients with Hepatic Encephalopathy/SONG Fangmin，LI Dan，WANG Liang.//Chinese and Foreign Medical Research，2019，17（19）：-18

【Abstract】 Objective：To observe the clinical effect of Nmda Ornithine combined with Lactulose on the treatment of patients with hepatic encephalopathy （HE）.

Method：A total of 72 HE patients were randomly divided into two groups according to the number table method，both groups were treated with comprehensive measures after admission，the control group（36 cases） was treated with Nmda ornithine on this basis，and the observation group（36 cases） was treated with lactulose on the basis of the control group，both groups were treated for 14 days.The total effective rate of the two groups were compared，and the expression levels of ALT，TBIL and serum ammonia before and after treatment were detected.The cognitive function status of the two groups before and after treatment were evaluated by number connection test（NCT） and digital symbol test（DST）.Result：The total effective rate in the observation group was 88.89%，significantly higher than 66.67% in the control group（P<0.05）.There was no significant difference about ALT，TBIL and serum ammonia levels between the two groups before treatment（P>0.05），and ALT，TBIL and serum ammonia levels of the two groups significantly decreased after treatment（P<0.05），and the observation group after treatment decreased more obvious than that of the control group（P<0.05）.There was no significant difference about NCT time and DST score between the two groups before treatment（P>0.05）.After treatment，the NCT time of the two groups was significantly shortened（P<0.05），and the DST score significantly increased（P<0.05）.The observation group after treatment was more significantly shortened and increased than that of the control group（P<0.05）.Conclusion：The treatment of Nmda Ornithine combined with Lactulose for HE patients has a significant curative effect，which can not only improve the liver function and reduce the blood ammonia level，but also improve the cognitive function of patients.