黄檀属植物化学成分和药理活性研究进展

2018-09-18 08:40赵惠玲韦建华
中国民族民间医药·上半月 2018年3期
关键词:药理活性化学成分

赵惠玲 韦建华

【摘 要】 黄檀属植物化学成分主要为黄酮及其苷类、香豆素类、醌类等,具有抗氧化、抗炎、抗菌、成骨活性、脑保护作用、止泻等多种生物活性。文章通过对国内外有关黄檀属植物的文献资料进行系统整理,对其化学成分和药理作用进行综述,以期为该属植物的开发利用提供参考。

【关键词】 黄檀属;化学成分;药理活性

【中图分类号】R284 【文献标志码】 A 【文章编号】1007-8517(2018)05-0040-08

Abstract:The major chemical constituents in plants of Dalbergia Linn. f. are flavonoids and its glycosides, coumarins and quinones. Researchs show the plants of Dalbergia Linn. f. have many biological activitives,including antioxidant activity,anti-inflammatory activity,antibacterial activity,osteogenic activity, cerebral protective effect and anti-diarrhea effect.This review focuses on the chemical structures of constituents and medical functions of Dalbergia Linn. f. It would provide a good reference to further utilize this medicinal plant.

Keywords:Dalbergia Linn. f.;Chemical Constituents;Pharmacological Effects

黄檀属Dalbergia Linn植物多为乔木、灌木或木质藤本。该属约100种,主要分布于亚洲、非洲和美洲的热带和亚热带地区。我国有28种,1变种,产西南部、南部至中部[1]。近年该属植物化学成分和药理研究主要集中在印度黄檀(Dalbergia sissoo)、降香(Dalbergia odorifera)、阔叶黄檀(Dalbergia latifolia Roxb.)等。文献报道从该属植物中提取分离得到黄酮及其苷类、香豆素类、醌类、三萜类等多种活性物质,具有抗氧化、抗炎、抗菌、成骨活性、脑保护作用、止泻等药理作用。笔者就该属植物化学成分及其药理作用的研究予以综述,以期能为该属植物资源的利用提供参考。

1 化学成分

目前,从黄檀属植物中已经发现的化学成分主要有黄酮类及黄酮苷类、香豆素类、醌类、三萜类等化合物。

1.1 黄酮及黄酮苷类化合物 黄酮类化合物广泛分布于植物界,从黄檀属植物中分离得到黄酮类化合物主要有异黄酮类、黄酮类、异黄烷类、查尔酮类及异黄酮苷类。具体见表1~5,图1~5。

1.2 香豆素成分 从黄檀属植物中分出4',7-dihydroxy-3'-methoxy-4-phenyl-2H-1-benzopyran-2-one等5个香豆素类化合物。详见表6。

1.3 醌类成分 黄檀属植物中醌类成分有sissoidenone、obtusaquinone等。详见表7。

1.4 酚类成分 黄檀属植物中还含有酚类成分,如(R)-latifolin、(R)-5-O-methyllatifolin和4-hydroxy-2'-methoxychalcone等。詳见表8。

1.5 三萜类成分 从黄酮属植物中分离出5个五环三萜类化合物。详见表9。

1.6 其他成分 黄檀属植物中还含有其他类成分,有Salicylic acid、β-sitosterol、Mucronulatol等。详见表10。

2 药理作用

2.1 抗氧化作用 Promden等[47]对小花黄檀中提取出来的24个异黄酮类化合物进行抗氧化活性研究,结果发现大豆异黄酮的抗氧化性最强;Huang Xing等[48] 对印度黄檀种子不同提取部位的抗氧化性进行研究,结果表明所有提取物均有抗氧化性,其中乙酸乙酯提取物作用最强,抗氧化性可能与黄酮类化合物。JiangAili等[49]考察降香黄檀叶不同提取部位的体外抗氧化活性研究,结果表明各个提取部位均有不同程度的体外抗氧化能力。Roy Nayan等[50]发现印度黄檀树皮的甲醇提取物比水提物的抗氧化活性更强。Khalid Mohammad等[51] 研究发现阔叶黄檀树皮提取物具有显著的抗氧化性。

2.2 抗炎活性 Lee Dong-Sung等[52] 对降香黄檀中的苯并呋喃类化合物进行抑制脂多糖诱导小鼠的小胶质细胞BV2研究。结果发现该类化合物能抑制脂多糖刺激小鼠的小胶质细胞BV2中HO-1,诱导型一氧化氮合酶、环氧化酶-2和前列腺素E2的表达,抑制TNF-α和IL-1的产生。Edayadulla等[53]以交叉菜胶诱导大鼠足肿胀模型,比较Dalbergia coromandeliana粗提物和单体化合物抗炎活性,结果发现其粗提物和单体化合物均有很高的抗炎活性。Ganga Rao B等[54] 以大鼠足肿胀模型对Dalbergia paniculata 叶的甲醇提取物的体内抗炎活性进行研究,发现其具有很好的抗炎活性。Lee Dong-Sung等[55]对降香黄檀中化学成分TMC对巨噬细胞中由HO-1产生的炎症的抗炎性质进行研究。结果发现TMC能促进Nrf2通路上的抗炎的OH-1的表达从而抑制炎症介质而产生抗炎作用。Wang Juan等[56]研究印度黄檀中的黄酮类化合物对RAW264.7巨噬细胞中脂多糖引起的炎症的抗炎活性,结果发现其中sativanone的抗炎活性最强,作用机制可能是减少一氧化氮的释放和抑制炎症因子TNF-α。

2.3 抗菌活性 Koma Okwute Simon等[57] 对黄檀的根材主要成分进行抗菌活性筛选,结果发现桦木酸对大肠杆菌和枯草杆菌较强的作用。Mutai Peggoty等[58]从非洲黑檀茎皮中分离出两个新的3-羟基异黄酮类化合物,活性研究发现均有抗结核分支杆菌的作用。

2.4 成骨活性 Im Nam Kyung等[59]对降香黄檀心材化学成分DMF抑制破骨细胞分化和作用进行研究。结果表明DMF能抑制受体活化剂核因子κ,通过破坏激动蛋白环的形成降低破骨细胞功能,抑制有丝分裂原蛋白激酶信号通路的核转录因子(激动的T细胞、活化T细胞核因子1蛋白(NFATc1)和c-Fos)。KumarPadam等[60]对降香黄酮心材的新黄酮类化合物的抗骨质疏松活性进行研究,共分出8个化合物,颅骨成骨细胞的碱性磷酸酶活性和矿化来评估其活性,发现化合物 1, 3, 5-8有显著的促进新骨形成的作用。 Khedgikar Vikram等[61]用绝经后骨质疏松小鼠模型研究印度黄檀叶和豆荚的正丁醇提取物(BSSF)对骨骼的影响。成年的S-D大鼠切除卵巢后,连续12周口服给BSSF(50和100mg/kg-1·d-1)或者雌激素。对骨微结构、骨转化标记物、生物力学强度、新骨形成、破骨细胞骨骼表达和再吸收基因标志物进行研究。结果发现,BSSF治疗能提高长骨的骨小梁微构筑和脊椎和股骨的生物力学强度,降低骨转化标记物和骨骼破骨细胞基因的表达以及提高新骨形成和股骨中破骨基因的表达。

2.5 脑保护作用 KulkarniSudhir C等[62] 以脑缺血再灌注引发的脑梗死大鼠模型研究阔叶黄檀中黄檀的脑保护活性可能的机制,研究表明阔叶黄檀树皮的甲醇提取物对环氧合酶抑制剂表现出协同作用,其作用机制可能是抑制环氧合酶途径。Li Bohui等[63] 研究包括印度黄檀在内的三种代表性的中药治疗心血管疾病(CVD)的作用机制。通过药物的吸收、分布、代谢及排泄(ADME)的结合使用筛选和网络药理学方法,发现其治疗CVD的活性成分和蛋白质靶点。揭示了活性成分和和潜在靶点、疾病和信号系统的关系。

2.6 止泻活性 Chandra Phool等[64]研究印度黄檀叶的乙醇提取物(EDSL)对小鼠腹泻和肠蠕动的保护作用,利用蓖麻油引起的腹泻和硫酸镁引起的腹泻测试对印度黄檀的抗腹泻活性进行评价,结果表明EDSL能显著减少排便量和腹泻情况,能延缓腹泻的发作时间。 Kalaskar M. G[65]用蓖麻油引起腹泻的小鼠模型研究印度黄檀树皮的抗腹泻活性,结果显示其有显著的、剂量依賴性的抗腹泻活性,提取物还能减少小肠炭末推进实验的小肠转运时间,与硫酸阿托品有相同的作用。

2.6 抗糖尿病活性 Pund Kiran V等[66]研究印度黄檀乙醇提取物对地塞米松引起的胰岛素抵抗小鼠的影响,观察小鼠血浆、血液葡萄糖、血浆甘油三酯、肝脏抗氧化酶(LPO, GSH, SOD和过氧化氢酶)等水平,结果显示高剂量组显著地降低血浆葡萄糖、甘油三酯水平和LPO的水平,增强GSH, SOD和过氧化氢酶水平。 Niranjan Pankaj Singh[67]等研究印度黄檀叶乙醇提取物对四氧嘧啶导致糖尿病的小鼠模型的降血糖活性,口服给药,连续21d给药后,低剂量组血糖水平降低至125mg/dL,高剂量组降低至104mg/dL,格列本脲组,比格列本脲的降血糖效果(降低至120mg/dL)更显著。

2.7 抗生育作用 Verma Hari Prakash等[68]研究印度黄檀叶水提物对雄鼠的形成和生育能力的影响,连续35d口服给药后,结果发现附睾的精子活力、生存能力和数量显著降低,提取物组血清睾酮水平也显著降低。Vasudeva Neeru等[69]对印度黄檀茎皮乙醇提取物对抗精子形成的影响进行研究,结果发现印度黄檀乙醇提取物对精子的活力和生存能力产生剂量依赖性和时间依赖性的影响,200mg/kg的乙醇提取物能显著降低睾丸和附睾的重量,附睾中的精子活力和数量也显著降低。

2.8 其他作用 Jaiganesh K P等[70]对 dalbergia spinosa roxb根提取物的利尿活性进行研究,结果发现乙醇提取物能增加尿量和电解质(钠、钾、氯),效果与强效利尿药呋塞米的效果相当。Choi Chun Whan等[71]对降香黄檀心材甲醇提取物的抗癌成分的研究,结果显示提取物能显著抑制增生期的癌细胞,抗癌活性主要成分是研究黄酮类和酚类化合物。 Hood M. M. [72]对印度黄檀不同提取物(石油醚、四氯化碳、苯和乙醇)的抗蚯蚓蠕虫活性进行研究,结果发现四种提取物有均有抗蠕虫活型,其中四氯化碳提取物的活性最高。

3 小结与展望

通过分析黄檀属植物国内外有关化学成分和药理活性的研究文献,发现黄檀属植物主要的化学成分是黄酮及其苷类化合物,且有着广泛而显著的药理作用,如抗氧化、抗炎、抗菌、成骨活性、脑保护作用、止泻等。从目前的研究来看,对黄檀属研究取得了一定的成果,尤其国外对其研究得比较多,但在国内其化学成分以及药理作用的研究尚不够深入。对生物活性的作用机制及药效物质基础仍未得到较好的阐明。亟待今后对其特色药理作用机制和活性成分进行深入研究,阐明其药效物质基础,一方面可以为黄檀属植物的开发利用提供科学依据,另一方面可为从天然产物中开发新药或药物先导化合物积累经验。

参考文献

[1]中国科学院《中国植物志》编辑委员会. 中国植物志:第2分册第53卷[M]. 北京:科学出版社,2000.

[2]Chawla, H. M.,Chibber, S. S. Occurrence of 7-hydroxy-4-methylcoumarin in Dalbergia volubilis[J]. Indian Journal of Chemistry,1977, 15B(5):492-493.

[3]Matos F. J. de Abreu,Gottlieb O. R. Ollis W. D, Andrade C. H. Souza . Chemistry of Brazilian Leguminosae. XXIV. Flavanoids of Dalbergia ecastophyllum[J]. Anais da Academia Brasileira de Ciencias,1970, 42(Supl.):61-64.

[4]Adinarayana, D,Radhakrishniah, M, Rao J. Rajasekhara. Occurrence of caviunin in Dalbergia paniculata (N. O. Leguminosae)[J]. Current Science,1971,40(22):602.

[5]Jurd L, Stevens K, Manners G. Phenolic and quinoidal constituents of dalbergia retusa[J]. Tetrahedron Letters, 1972, 13(21):2149-2152.

[6]Jurd L, Stevens K, Manners G. Isoflavones of the heartwood of dalbergia retusa[J]. Phytochemistry, 1972, 11(8):2535-2540.

[7]Dhingra, V. K.,Seshadri, T. R.,Mukerjee, S. K. Isotectorigenin from the bark of Dalbergia sissoo[J]. Indian Journal of Chemistry,1974, 12(10), 1118.

[8]Adinarayana, D., Rao J. Rajasekhara. Isoflavonoids of Dalbergia paniculata[J]. Indian Journal of Chemistry,1975, 13(4):425-426.

[9]Parthasarathy M R, Seshadri T R, Varma R S. Triterpenoids and flavonoids of Dalbergia sericea, bark[J]. Phytochemistry, 1976, 15(1):226-227.

[10]Dayal R, Parthasarathy M R. Phenolic constituents of Dalbergia sericea leaves[J]. Planta Medica, 1977, 31(3):245-8.

[11]Shirley L I M. Phenolic compounds from the heartwood of Dalbergia nitidula[J]. Phytochemistry, 1976, 15(2):353-354.

[12]Kurosawa Kazu, Ollis W. D,Redman B T,et al.Isoflavonoid constituents of Dalbergia and Machaerium species. Part 6. Absolute configurationsof isoflavans[J]. Phytochemistry ,1978, 17(8):1423-1426.

[13]Chibber S S, Sharma R P. Isolation of 6-hydroxy-2,7-dimethoxy -4, 5-methylenedioxy isoflav-one from the Pods of Dalbergia Assamica[J]. Current Science, 1978, 47(22), 856-857.

[14]Cook J T,Ollis W D,Sutherland I O,et al. Isoflavonoid constituents of Dalbergia and Machaerium species. Part 5. Pterocarpans from Dalbergia spruceana[J]. Phytochemistry,1978,17(8):1419-1422.

[15]Ingham J L. Isoflavonoid Phytoalexins from Leaflets of Dalbergia sericea[J]. Zeitschrift Für Naturforschung C, 1979, 34(7-8):630-631.

[16]Gregson Michael,Ollis W D, Sutherland I O. Neoflavonoid group of natural products.Part4.Violastyrene and isoviolastyrene, cinnamylphenols from Dalbergia miscolobium[J]. Phytochemistry,1978, 17(8), 1375-1377.

[17]Yahara S, Ogata T, Saijo R, et al. Isoflavan and related compounds from Dalbergia odorifera. I.[J]. Chemical & Pharmaceutical Bulletin, 1989, 37(4):979-987.

[18]Dasan R. G,Nagarajan N. S, Narayanan V,et al. Dalspinin and dalspinosin, two new isoflavones from Dalbergia spinosa roots[J]. Indian Journal of Chemistry,1982, 21B(4):385-386.

[19]Chawla H. M,Johny C. J,Mittal R S. New phenolic components from Dalbergia volubilis[J]. Bulletin de la Societe Chimique de France,1989(1):82-87.

[20]Bhatt P, Dayal R. Stipulin, a prenylated chalcone from Dalbergia stipulacea[J]. Phytochemistry, 1992,31(2):719-721.

[21]Chan S C, Chang Y S, Wang J P, et al. Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera[J]. Planta Medica, 1998, 64(2):153-158.

[22]Khera U,Chhiber S. S. . Isolation of 4'-O-gentiobioside and 4'-O-glucoside of 7-O-methyltectorigenin from Dalbergia volubilis[J]. Indian Journal of Chemistry,1978,16B(7):641-643.

[23]Narayanan V, Seshadri T R. Paniculatin, a new isoflavone-di-C-glucoside of Dalbergia paniculata Bark[J]. Indian Journal of Chemistry, 1971,9(1):14-16.

[24]Radhakrishniah M. Chemical constituents of Dalbergia paniculata roots[J]. Journal, 1979, 56(1):81-83.

[25]Rajulu K G, Rao J R. Caviunin 7- O -rhamnoglucoside from Dalbergia paniculata, root[J]. Phytochemistry, 1980, 19(7):1563-1563.

[26]Khera U, Chibber S S. Tectorigenin 7-gentiobioside from Dalbergia volubilis stem bark[J]. Phytochemistry, 1978, 17(3):596-596.

[27]Gandhidasan R,Hariramakrishnan,KNeelakantan S,et al. Dalspinosin 7-O-β-D-glucopyrano-side, a new isoflavone glycoside from the roots of Dalbergia spinosa Roxb[J]. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1988, 27B(7):693.

[28]Narayanan V, Nacarajan N S. Two isoflavone galactosides from Dalbergia spinosa[J]. Phytochemistry, 1988, 27(7):2364-2365.

[29]Donnelly B J, Donnelly D M X, O'Sullivan A M. Dalbergia Species—VI : The occurrence of melannein in the genus dalbergia[J]. Tetrahedron, 1968, 24(6):2617-2622.

[30]Saxena V K,Tiwari K P,Tandon S P. New 4-phenylcoumarin 'sisafolin' from Dalbergia latifolia[J].1970, 40(Pt. 2):165-169.

[31]Heerden F R V, Brandt E V, Roux D G.Structure and synthesis of some complex pyranoisoflavonoids from the bark of Dalbergia nitidula Welw. ex Bak[J].Journal of the Chemical Society Perkin Transactions, 1978, 2(20):137-145.

[32]Yesumarian Y, Krishnamoorthy M K, Ramasamy G, et al. Photodynamic action and antim-icrobial activity of some excited metabolites of Dalbergia sissoides and their ability to cleave DNA[J]. Natural Product Communications, 2007, 2(2):159-168.

[33]Ravi P,Narayanan V,Raman P V. A novel quinone from Dalbergia sissoides Grah[J].Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1989,28B(9):778-779.

[34]Jurd L, Stevens K, Manners G. Quinonoid constituents of Dalbergia retusa, heartwood[J]. Phytochemistry, 1972, 11(11):3287-3292.

[35]Donnelly D M X, Nangle B J, Prendergast J P, et al. Dalbergia, species—V. Isolation of R-5- O-methyllatifolin from Dalbergia cochinchinensis, Pierre[J]. Phytochemistry, 1968, 7(4):647-649.

[36]Jurd L,Roitman J N. Quinones and quinone methides. II. Cyclization and hydration reactions of 2-cinnamyl-5-methoxy-1,4benzoquinones[J]. Tetrahedron,1978,34(1):57-62.

[37]Ocriodain T, Osullivan M, Meegan M J, et al. Dalbergia wood constituents. 13. Latinone, a phenanthrene-1,4-quinone from Dalbergia latifolia[J].Phytochemis try,1981, 20(5):1089-1092.

[38]Dhingra V K, Mukerjee S K, Saroja T, et al. Chemical examination of the bark and sapwood of Dalbergia latifolia[J]. Phytochemistry, 1971, 10(10):2551-2551.

[39]Dealmeid. M E, Gottlieb O R. Chemistry of Brazilian leguminosae. XLIV. Iso- and neoflavonoids from Dalbergia inundata[J]. Phytochemistry,1974, 13(4):751-752.

[40]Shirota O,Pathak V,Sekita S,et al. Phenolic constituents from Dalbergia cochinchinensis[J]. Journal of natural products,2003, 66(8):1128-1131.

[41]Aiyar V N, Dayal R, Seshadri T R. Triterpenoids from the stem-bark of Dalbergia sericea[J]. Current Science, 1974.

[42]Jurd L, Manners G, Stevens K. Isolation and synthesis of (±)-obtusafuran[J]. Journal of the Chemical Society Chemical Communications, 1972(17):992-993.

[43]Donnelly, D. M. X, O'Reilly J,Thompson J. Dalbergia species. VIII. Neoflavanoids of Dalbergia cultrata[J]. Phytochemistry,1972, 11(2):823-826.

[44]Alencar R D, Filho R B, Gottlieb O R. Pterocarpanoids from Dalbergia decipularis[J]. Phytochemistry, 1972, 11(4):1517-1517.

[45]Soni P L. chemistry of extractives of Dalbergia sissoo. I. The occurrence of 3,5 dihydroxy trans stilbene in the heartwood[J]. Journal, 1975, 6(2):57-58.

[46]Muangnoicharoen N, Frahm A W. Arylbenzofurans from Dalbergia parviflora[J]. Phytochemistry, 1981, 20(2):291-293.

[47]Promden W, Monthakantirat O, Umehara K, et al. Structure and antioxidant activity relationships of isoflavonoids from Dalbergia parviflora[J]. Molecules, 2014, 19(2):2226.

[48]Huang Xing,Zheng Lianhe,Wang Li,et al. In vitro antioxidant activity of Dalbergia odorifera T. Chen seed extract[J]. Shipin Gongye Keji,2012, 33(5):49-51.

[49]Jin-Yu L I. In vitro Antioxidant Activity of the Extracts from Dalbergia Leaves[J]. Journal of Anhui Agricultural Sciences, 2013, 41(9):3853-3856.

[50]Roy N, Laskar R A, Sk I, et al. A detailed study on the antioxidant activity of the stem bark of Dalbergia sissoo Roxb. an Indian medicinal plant[J]. Food Chemistry, 2011, 126(3):1115-1121.

[51]Kahlert M, Albert R L, Anttila E L, et al. In-vitro Assessment of Antioxidant Activity of Dalbergia latifolia Barks Extract Against Free Radicals[J]. European Geriatric Medicine, 2014, 5(7):188-194.

[52]Lee Dong-Sung, Jeong Gil-Saeng. Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity[J]. European Journal of Pharmacology, 2014(728):1-8.

[53]Edayadulla N, Ramesh P. Anti- inflammatory action of crude extract and isolated compounds from the stems of Dalbergia coromandeliana[J].Journal of Pharmacy Research,2012,5(7):3841-3843.

[54]Santiago D O B R, Acácio R R, Pires D L F J, et al. Fine-scale spatial genetic structure ofDalbergia nigra(Fabaceae), a threatened and endemic tree of the Brazilian Atlantic Forest[J]. Genetics & Molecular Biology, 2012, 35(4):838-846.

[55]Lee DS, Li B, Im NK,et al. 4,2',5'-trihydroxy-4'-methoxychalcone from Dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages[J]. International Immunopharmacology, 2013, 16(1):114-121.

[56]Wang J, Jiang W, Wang Y. Anti-inflammation of flavonoid compounds from Dalbergia odorifera T. Chen in lipopolysaccharide stimulated RAW264.7 macrophages[J].Chinese Journal of Cellular & Molecular Immunology,2013, 29(7):681-684.

[57]Koma O S, Sani I M. Betulinic acid from antimicrobial root wood extract of Dalbergia saxatilis Hook f.(Fabaceae)[J]. European Journal of Medicinal Plants, 2014, 4(6):686-694.

[58]Mutai P, Heydenreich M, Thoithi G, et al. 3-Hydroxyisoflavanones from the stem bark of Dalbergia melanoxylon : Isolation, antimycobacterial evaluation and molecular docking studies[J]. Phytochemistry Letters, 2013, 6(4):671-675.

[59]Im NK, Choi JY, Oh H,et al. 6,4'-dihydroxy-7-methoxyflavanone Inhibits Osteoclast Differe-ntiation and Function[J]. Biological & Pharmaceutical Bulletin, 2013, 36(5):796-801.

[60]Kumar P, Kushwaha P, Khedgikar V, et al. Neoflavonoids as potential osteogenic agents from Dalbergia sissoo heartwood[J]. Bioorganic & Medicinal Chemistry Letters, 2014, 24(12):2664-2668.

[61]Khedgikar V, Gautam J, Kushwaha P, et al. A standardized phytopreparation from an Indian medicinal plant (Dalbergia sissoo) has antiresorptive and bone-forming effects on a postmenopausal osteoporosis model of rat[J]. Menopause-the Journal of the North American Menopause Society, 2012, 19(12):1336-1346.

[62]Kulkarni Sudhir C,Nagarathna P. K. M,Vasanthkumar C,et al. Determination of possible mechanism of cerebroprotective action of flavonoid of Dalbergia latifolia against cerebral ischemia reperfusion induced-cerebral infarction in rats[J]. Research & Reviews: Journal of Pharmacy and Pharmaceutical Sciences,2013, 2(4):19-26.

[63]Li B, Xu X, Wang X, et al.A systems biology approach to understanding the mechanisms of action of chinese herbs for treatment of cardiovascular disease[J]. International Journal of Molecular Sciences, 2012, 13(10):13501-13520.

[64]Phool C, Neetu S, Dilipkumar P. Protective effect of Dalbergia sissoo Roxb. ex DC. (family: Fabaceae) leaves against experimentally induced diarrhoea and peristalsis in mice[J]. Toxicology & Industrial Health, 2015, 31(12):1229-1235.

[65]Kalaskar M G, Divekar V B, Chaugule P D, et al. Studies on anti-diarrheal activity of Dalberjia Sissoo Roxb. in experimental animals[J]. Pharmacologyonline, 2010(1):453-457.

[66]Kiran V. Pund, Neeraj S. Vyawahare, Vilas K. Murkute, et al. Effect of Dalbergia sissoo Roxb on dexamethasone-induced insulin resistance in mice[J]. Inventi Impact Ethnopharmacology, 2012(1):13-15.

[67]Niranjan P S,Singh D,Prajapati K,et al. Antidiabetic activity of ethanolic extract of Dalbergia sissoo L. leaves in alloxan-induced diabetic rats[J].International Journal of Current Pharmaceutical Research,2010, 2(2):24-27.

[68]Verma H P, Singh S K. Effect of aqueous leaf extract of Dalbergia sissoo Roxb. on spermatogenesis and fertility in male mice[J]. The European journal of contraception & reproductive health care,2014,19(6):475-486.

[69]Vasudeva N, Vats M. Anti-spermatogenic activity of ethanol extract of Dalbergia sissoo Roxb. stem bark.[J]. Journal of Acupuncture & Meridian Studies, 2011, 4(2):116-122.

[70]Jaiganesh K P, Akilandeshwari S, Senthamarai R. Diuretic Activity Of Root Extracts of Dalbergia Spinosa Roxb[J]. Ancient Science of Life, 2009, 28(3):11-13.

[71]Choi C W, Choi Y H, Cha M R, et al. Antitumor components isolated from the heartwood extract of Dalbergia odorifera[J]. Journal of the Korean Society for Applied Biological Chemistry, 2009, 52(4):375-379.

[72]Hood M M, Tembhurne S V, Sakarkar D M. Anthelmintic activity of different extracts of Dalbergia sissoo Roxb. on Indian Adult Earthworms[J]. Der Pharma Chemica, 2015, 3(2):142-146.

(收稿日期:2018-01-23 編辑:程鹏飞)

猜你喜欢
药理活性化学成分
半枫荷化学成分及药理活性研究进展
壮药积雪草主要化学成分及对神经系统作用的研究进展
金线莲的研究进展