俞亮++杨帆++黄佳伟
DOI:10.16662/j.cnki.1674-0742.2017.20.043
[摘要] 目的 对高压氧联合神经节苷脂治疗对颅脑外伤的神经保护作用的临床效果进行研究观察分析。方法 方便选取该院2013年12月—2016年10月收治的92例颅脑损伤患者,根据治疗方式不同分为对照组与观察组,平均每组46例。对照组给予常规治疗,观察组给予高压氧联合神经节苷脂治疗治疗,对比两组临床效果并观察分析。结果 对照组总治愈率为28.26%,死亡率为19.57%。观察组总治愈率为47.82%,死亡率为4.35%,两组间数据对比差异有统计学意义(P<0.05)。治疗前两组患者GCS评分与Barthel指数对比差异无统计学意义(P>0.05),治疗后观察组GCS评分与Barthel相比较对照组均有所提升,组间比较差异有统计学意义(P<0.05)。结论 经过高压氧联合神经节苷脂治疗对颅脑外伤的神经保护作用效果确切,患者神经功能恢复快,且接受度高,适用于各临床颅脑损伤患者,值得各医院推广及应用。
[关键词] 高压氧;神经节苷脂;颅脑外伤;神经保护作用
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2017)07(b)-0043-03
Effect of High Pressure Oxygen and Ganglioside Treatment on the Nerve Protection of Cerebral Trauma
YU Liang, YANG Fan, HUANG Jia-wei
Department of Neurology, Leyu Town Peoples Hospital, Zhangjiagang, Jiangsu Province, 215600 China
[Abstract] Objective To research the effect of high pressure oxygen and ganglioside treatment on the nerve protection of cerebral trauma. Methods 92 cases of patients with cerebral trauma admitted and treated in our hospital from December 2013 to October 2016 were convenient selected and divided into two groups with 46 cases in each, the control group adopted the routine treatment, while the observation group were treated with high pressure oxygen and ganglioside, and the clinical effect was compared and observed. Results The differences in the total cure rate and death rate between the control group and the observation group were statistically significant(28.26%, 19.57% vs 47.82%, 4.35%)(P<0.05), before treatment, there were no obvious differences in the GCS score and Barthel index between the two groups(P>0.05), after treatment, the GCS score and Barthel index of the two groups were improved and the difference was statistically significant(P<0.05). Conclusion The effect of high pressure oxygen and ganglioside treatment on the nerve protection of cerebral trauma is definite with rapid nerve function and high acceptance, which is suitable for various patients with cerebral wounds, and it is worth promotion and application.
[Key words] High pressure oxygen; Ganglioside; Cerebral trauma; Nerve protection function
顱脑外伤是神经外科一种常见临床疾病,由于发病紧急,病情发展迅速,而且致残率与致死率很高[1]。该研究方便选取该院2013年12月—2016年10月92例颅脑损伤患者,对高压氧联合神经节苷脂治疗对颅脑外伤的神经保护作用的临床效果进行研究观察分析,现报道如下。
1 资料与方法
1.1 一般资料
方便选取2013年12月—2016年10月该院就诊的颅脑损伤患者92例,入选标准:①入院后均影像学检查,临床诊断明确;②年龄在20~75岁;③格拉斯评分为5~8分[2];④经头颅CT和MRI检测证实,排除心、肺、肝、肾等功能不全者,排除精神障碍患者,排除合并其他严重器质性病变患者;⑤签署治疗知情同意书。随机将92例患者分为对照组和观察组,每组46例。对照组46例患者年龄在20~75岁,平均(47.4±11.2)岁,其中男25例,女21例;观察组46例患者中男23例,女23例,年龄在23~72岁,平均(46.8±11.7)岁。两组患者在一般资料上比较差异无统计学意义(P>0.05),有可比性。endprint