盐酸纳美芬联合曲克芦丁脑蛋白水解物注射液治疗新生儿缺氧缺血性脑病的临床效果

龚梨林

【摘要】 目的：探討盐酸纳美芬联合曲克芦丁脑蛋白水解物注射液治疗新生儿缺氧缺血性脑病的临床效果。方法：选取2012年10月-2015年11月本院确诊治疗的缺氧缺血性脑病患儿100例，依据随机分配原则分为美芬蛋白组和美芬组，每组50例。美芬组患儿给予常规基础治疗及盐酸纳美芬治疗，美芬蛋白组患儿在此基础上给予曲克芦丁脑蛋白水解物注射液治疗，采用神经行为测定（NBNA）评分评估患儿的神经功能，采用Gesell发育量表评估患儿智能发育情况，并统计分析患儿的临床疗效和不良反应发生情况。结果：美芬蛋白组患儿治疗总有效率、NBNA评分及DQ均明显高于美芬组，差异均有统计学意义（P<0.05）；美芬蛋白组和美芬组患儿不良反应发生率分别为16.00%、6.00%，两组比较差异无统计学意义（P>0.05）。结论：盐酸纳美芬联合曲克芦丁脑蛋白水解物注射液治疗可有效缓解新生儿缺氧缺血性脑病的临床症状，提高患儿的临床疗效，且具有良好的安全性，值得临床作进一步推广。

【关键词】 新生儿； 缺氧缺血性脑病； 盐酸纳美芬； 曲克芦丁脑蛋白水解物注射液

【Abstract】 Objective：To explore the clinical efficacy of Nalmefene Hydrochloride combined with Troxerutin and Cerebroprotein Hydrolysate Injection in treatment of newborn hypoxic ischemic encephalopathy.Method：100 children with hypoxic ischemic encephalopathy in our hospital from October 2012 to November 2015 were selected，they were randomly divided into Mefene-protein group and Mefene group，50 cases in each group.The Mefene group was given conventional treatment and Nalmefene Hydrochloride treatment，while the Mefene-protein group was additionally given Cerebroprotein Hydrolysate Injection treatment.Neonatal behavioral neurological assessment（NBNA） score was used to assess the neurological function，and the Gesell development scale was used to assess the intelligence development of the children，the clinical efficacy and adverse reactions of the patients were statistically analyzed.Result：The total effective rate，NBNA score and DQ of Mefene-protein group were significantly higher than those in Mefene group（P<0.05）.The incidence of adverse reactions was 16.00% in the Mefene-protein group and 6.00% in the Mefene group，the difference was no statistically significant（P>0.05）.Conclusion：Nalmefene Hydrochloride combined with Troxerutin and Cerebroprotein Hydrolysate Injection can effectively alleviate the clinical symptoms of neonatal hypoxic ischemic encephalopathy，improve the clinical efficacy of children，and has a good safety，it is worth of further promotion.

【Key words】 Newborn； Hypoxic ischemic encephalopathy； Nalmefene Hydrochloride； Troxerutin and Cerebroprotein Hydrolysate Injection

First-authors address：Fengcheng Peoples Hospital，Fengcheng 331100，China

doi：10.3969/j.issn.1674-4985.2016.36.028

新生儿缺氧缺血性脑病是临床上新生儿常见的一种临床高危病症，是围生期新生儿因缺氧引起脑部病变所致，可导致意识模糊、惊厥、呼吸节律不齐等症状，严重影响患儿的身体健康[1]。目前，新生儿缺氧缺血性脑病临床上多采用吸氧、保暖、降颅内压、止惊等基础治疗[2-4]，可有效缓解患儿的临床症状，但由于新生儿体质虚弱，导致疗效欠佳，故如何提高患儿的临床疗效成为了广大学者重点关注的问题。对此，本研究通过给予患儿盐酸纳美芬联合曲克芦丁脑蛋白水解物注射液治疗，探讨其对患儿的疗效的影响及其安全性，现报道如下。

1 资料与方法endprint