恶性黑色素瘤的细胞免疫治疗研究进展

吴育罗+黄冠军

[摘要] 恶性黑色素瘤是一种恶性程度极高且发病率持续增长的肿瘤，对术后辅助放、化疗不敏感，预后较差。研究发现，恶性黑色素瘤为免疫原性较高的肿瘤，因此，肿瘤生物治疗得到广泛应用，细胞免疫治疗已成为恶性黑色素瘤个体化综合治疗的重要组成部分及研究热点。本文就恶性黑色素瘤的细胞免疫治疗研究进展作一综述。

[关键词] 恶性黑色素瘤；细胞免疫治疗；研究进展

[中图分类号] R730.5 [文献标识码] A [文章编号] 1674-4721（2014）09（c）-0194-03

Research progress on cell immunotherapy of malignant melanoma

WU Yu-luo HUANG Guan-jun

Cancer Prevention and Control Center，Affiliated Zhanjiang Cental People′s Hospital of Guangdong Medical College，Zhanjiang 524037，China

[Abstract] Malignant melanoma is among the most lethal of the cutaneous neoplasms，and the incidence of it has been rising over the past few decades Malignant melanoma is not sensitive to chemotherapy and radiation therapy，and has a poor prognosis.Studies found that malignant melanoma shows a high immunogenicity，therefore，tumor biologic therapy is widely applicated.Cell immunotherapy has become an important part of individualizedly systematic treatment and research hot spot.In this paper，research progress on cell immunotherapy of malignant melanoma was reviewed.

[Key words] Malignant melanoma；Cell immunotherapy；Research progress

恶性黑色素瘤的细胞免疫治疗研究进展

吴育罗 黄冠军

广东医学院附属湛江中心人民医院肿瘤防治中心，广东湛江 524037

[摘要] 恶性黑色素瘤是一种恶性程度极高且发病率持续增长的肿瘤，对术后辅助放、化疗不敏感，预后较差。研究发现，恶性黑色素瘤为免疫原性较高的肿瘤，因此，肿瘤生物治疗得到广泛应用，细胞免疫治疗已成为恶性黑色素瘤个体化综合治疗的重要组成部分及研究热点。本文就恶性黑色素瘤的细胞免疫治疗研究进展作一综述。

[关键词] 恶性黑色素瘤；细胞免疫治疗；研究进展

[中图分类号] R730.5 [文献标识码] A [文章编号] 1674-4721（2014）09（c）-0194-03

Research progress on cell immunotherapy of malignant melanoma

WU Yu-luo HUANG Guan-jun

Cancer Prevention and Control Center，Affiliated Zhanjiang Cental People′s Hospital of Guangdong Medical College，Zhanjiang 524037，China

[Abstract] Malignant melanoma is among the most lethal of the cutaneous neoplasms，and the incidence of it has been rising over the past few decades Malignant melanoma is not sensitive to chemotherapy and radiation therapy，and has a poor prognosis.Studies found that malignant melanoma shows a high immunogenicity，therefore，tumor biologic therapy is widely applicated.Cell immunotherapy has become an important part of individualizedly systematic treatment and research hot spot.In this paper，research progress on cell immunotherapy of malignant melanoma was reviewed.

[Key words] Malignant melanoma；Cell immunotherapy；Research progressendprint