Cervical spondylotic myelopathy with syringomyelia presenting as hip Charcot neuroarthropathy: A case report and review of literature

INTRODUCTION

Charcot neuroarthropathy (CN), or Charcot joint, is a systemic disease characterized by progressive bone loss and destruction of the joints and/or spine usually accompanied by dysfunctions of sensitive and autonomic nerves and is reported to be closely associated with diabetes mellitus, HIV, chronic alcoholism, end-stage renal disease, gigantism, intra-articular steroid injections, peripheral neuropathy,meningomyelocele, multiple sclerosis, myelodysplasia, leprosy, amyloidosis, and congenital pain insensitivity[1-3]. However, CN caused by syringomyelia accounts for approximately 5% of CN cases[4]. A retrospective study showed that syringomyeliaassociated CN most often involves the shoulder (17 of 33, 50.0%) and elbow (17 of 33,50.0%), while the hip joint is rarely involved (1 of 33, 2.94%)[5]. To date, a few cases of CN associated with syringomyelia have been reported, but a case report of CN of the hip caused by syringomyelia secondary to cervical spondylotic myelopathy (CSM) has never been published. Therefore, the purpose of this report is to discuss this rare pathological association and to provide new insights into the surgical treatment of CN.

CASE PRESENTATION

Chief complaints

A 76-year-old male patient presented to the Department of Orthopedics of our hospital complaining of worsening progressive right hip pain, a limp when walking and weakness of the right hip. He was admitted to our hospital.

History of present illness

The patient’s symptoms started four years ago with recurrent swelling of the right hip with mild pain, which had worsened in the last 48 h.

History of past illness

The patient initially presente d with neck pain and weakness in all four limbs 16 years ago and was diagnosed with cervical spondylosis, which was treated conservatively.

Personal and family history

The patient had an unremarkable personal and family history.

Physical examination

The patient reported mild pain with flexion and extension of the cervical spine and activity limitation. Apparent swelling was observed in the left hip, and more than 110 mL of clear yellowish joint fluid was extracted. The active range of motion of the right hip was recorded as follows: flexion 90°, abduction 30°, internal rotation 20°, and external rotation 35°, with pain in all directions. The visual analog score was 6/10 points, and the Harris hip score (HHS) was 56 points. Neurologically, the sensation of pain and temperature in the upper and lower extremities was decreased, and proprioception and position sensation were normal. A pathologic reflex was not elicited. Both upper limbs and the right lower limb exhibited weakness with a muscle strength of 4/5, the muscle strength of the left lower limb was normal at 5/5, the right abductor had a muscle strength score of 5/5, and the modified Japanese Orthopedic Association score for CSM was 9/17 points. The bone mineral density (BMD) of the hip was 0.45 g/cm, and the T score was -2.9. Laboratory results were nonspecific.

产销差率是指销售水量和供给水量的比值。有研究表明，全球产销差率平均在27%左右，欧美、日本等发达国家的产销差率比较低，在10%以下。而非洲、拉丁美洲等发展中国家产销差率高，达到了40%以上[1]。

Laboratory examinations

Blood biochemistry and urine analyses were normal. Electrocardiogram, chest X-ray and arterial blood gases were also normal. The BMD of the hip was 0.45 g/cm, and the T score was -2.9.

Imaging examinations

Magnetic resonance imaging (MRI) of the cervical spine showed cervical syringomyelia at C4, cervical disc herniation and spinal canal stenosis from the C3 to the C7 levels (Figure 1). Cervical computed tomography (CT) revealed destruction of the vertebral body at C4 and C5–7 vertebral body assimilation (Figure 2). Threedimensional CT reconstruction, CT scans, and X-rays of the right hip joint showed joint space loss, articular surface collapse, and destructive changes in the acetabulum and femoral head (Figure 3A-C). T2W1 MRI of the right hip showed articular cartilage loss, degeneration of the joint, disordered soft tissue, and apparent joint fluid(Figure 3D).

FINAL DIAGNOSIS

The final diagnosis was CN of the hip associated with syringomyelia and CSM

TREATMENT

● 遥控：自动或手动远程控制路灯的开/关/调光，可依据路灯的用途、马路类型分别配置不同的开、关、调光时间。

OUTCOME AND FOLLOW-UP

September 1, 2021

DISCUSSION

CN is considered a multifactorial disease that may lead to progressive bone resorption and destruction of the joints and further develop into joint instability, deformity, and structural collapse with or without pain[6,7]. The possible pathogenesis includes the following: (1) Inflammatory cascading reactions caused by excessive expression of proinflammatory cytokines lead to an increase in osteoclastogenesis; (2) Abnormal neurovascular reflexes at joints promote osteoclast activation, leading to osteopenia;and (3) Painful sensory neuropathy and local temperature increases lead to the accumulation of microtrauma, resulting in joint dislocation and collapse[8,9]. Diabetes is considered the most common cause of CN and usually affects the foot and ankle joints[10]. However, syringomyelia-associated CN accounts for only approximately 5%of CN cases and easily causes upper limb CN[4,11], which most frequently involves the shoulder and elbow joints[3,12]. Only a few studies have reported that CN of the hip and knee joint is a rare complication of lumbar syringomyelia caused by epidural anesthesia[13,14].

Syringomyelia is a chronic progressive condition in which cystic tubular cavitation of the spinal cord is commonly caused by disorders of normal cerebrospinal fluid(CSF) flow dynamics. The possible mechanisms of syringomyelia include: (1) CSF transfer from the fourth ventricle to the central canal[15,16]; and (2) CSF filtration through medullary channels through perivascular and interstitial metastasis[17].While the etiology of syringomyelia is not completely understood, Chiari 1 malformation is generally considered the most significant etiology. Other possible causes include Chiari 2 malformation, myelomeningocele, tethered cord syndrome,hydrocephalus, infection, inflammatory conditions, trauma, extramedullary tumors,arachnoid cysts and spinal canal stenosis[18,19]. As a rare factor, CSM associated with syringomyelia is scarcely reported in the literature[20]. Four potential pathologic mechanisms have been considered for cervical syringomyelia secondary to CSM:Ischemia causing degeneration, microtrauma caused by persistent oppression,hydrodynamic changes in CSF, and the dynamic pincer effect[21]. In addition,enhanced blood flow signals in compressed segments of the cervical spinal cord suggest that dyskinesia of CSF movement may play a role in the process of lesion development[22,23]. The typical clinical manifestation of syringomyelia is weakening or loss of pain and temperature sensation, but proprioception and position sensation are maintained, which is known as "free anesthesia", with muscular atrophy and undernourishment at the level of lesions. With loss of the normal protective reflex,joints may suffer from unrecognized trauma or repeated injury, eventually leading to the occurrence of CN.

In this case, the patient had no significant previous medical history except for CSM diagnosed 16 years prior. According to the MRI results, we found that the patient had CSM and cervical syringomyelia at C4, without other special lesions. Therefore, we suspected that cervical syringomyelia at C4 was associated with long-term CSM,although this is an extremely rare pathological association. Meanwhile, a typical X-ray showed severe hip deterioration, bone loss, and destruction. Interestingly, we carried out systemic physical, laboratory and imaging examinations on the patient, which confirmed that the patient's blood glucose and laboratory results were normal,indicating no other systemic diseases. Therefore, we excluded the differential diagnoses of congenital pain insensitivity, infection and inflammatory joint disease.Finally, after discussion with neurologists and radiologists, the patient was diagnosed with CN of the right hip caused by cervical syringomyelia secondary to CSM.

县域电力通信网作为最末端的电力通信网，承载电网与用户的信息交互，是电网业务向服务化转型的最前沿。而现有的低压侧通信大都采用无线公网技术，尚不能承载如此庞杂的信息量，如何应对用户侧的信息交互是电力通信网研究中的一个难题，还需要考虑此类信息的储存问题。智能电网发展将为电力通信网带来新的挑战，也是电力通信网全面发展的契机。

We suggest a possible etiological association between CSM and syringomyelia, which may reflect a potential pathogenesis of CN. A differential diagnosis should be established for patients with joint swelling, pain and limited mobility, especially patients with chronic shoulder and neck pain. Imaging examinations should be actively performed to rule out the possibility of syringomyelia secondary to CSM.Therefore, the key to successful treatment of patients with CN is comprehensive medical history acquisition, examination and early diagnosis. In addition, arthroplasty may no longer be an absolute contraindication to surgical treatment of CN. Reasonable selection of the surgical strategy can markedly improve the clinical symptoms and quality of life of patients.

Grade C (Good): 0

易开裂区为计算拉应力超过材料抗拉强度的区域，表明易开裂区如图10所示，内部易开裂区如图11所示。由于动力条件下廊道应力值较静力条件下增大在15%以内，而混凝土动强度比静强度有所提高，所以地震工况下廊道易开裂区没有显著增大。在进行廊道材料和结构设计时，只要满足其静力工况下的材料强度要求，就能保证满足设计地震工况下材料强度要求。

综上所述，UV法结合金属离子沉淀法操作简便、准确，精密度、稳定性、重复性好，可用于米索硝唑pH敏感脂质体中主成分的含量测定，其结果与HPLC法含量测定结果一致。

Therefore, adopting reasonable precautions to provide a fixed prosthesis and increase the stability of the hip joint is particularly important to avoid early complications, including: (1) The use of a larger diameter femoral head to reduce the risk of postoperative dislocation; (2) The use of a highly cross-linked polyethylene lining to reduce wear; (3) The use of 3D CT template software to produce femoral stems with appropriate anteversion and femoral offset; (4) The use of a CT navigation system to reproduce the preoperative plan as much as possible; (5) Judicious use of dual mobility constructs; and (6) Revision of the acetabular component and the use of multiple acetabular screws to enhance the firmness of the component[26,29,30]. In addition, we should adhere to conservative treatments during the perioperative period, such as weight-bearing, immobilization, passive stretching, physical therapy and nonsteroidal anti-inflammatory drugs[5].

In our case, the patient refused to undergo cervical decompression surgery. To relieve the pain in the hip joint and restore the motor function of the limbs, we performed right THA. In the preoperative evaluation, the patient suffered from osteoporosis and bone fragmentation and loss around the hip. We suspect that the mass and strength of bone around the hip joint cannot provide sufficient stability at the bone-implant interface if a biotype acetabular cup is adopted. Moreover, the cement-type prosthesis possesses a short curing time, and strong fixation is achieved immediately after curing. Two to three days postoperatively, the patient can begin to bear partial weight with support, which reduces perioperative complications. During the operation, to reduce the risk of dislocation, we used the Hardinge approach to preserve the external rotator muscle group, which can reduce hip joint stability impairment with close suturing of the joint tendon. The cement-type Lubinus antidislocation acetabular cup and a biological fully coated biconical femoral stem were used to improve stability and promote bone ingrowth. After surgery, the patient's symptoms improved, without complications such as recurrent dislocation, loosening of the femoral prosthesis, and fracture around the prosthesis.

CONCLUSION

Early CN is difficult to distinguish from other diseases due to a lack of characteristic clinical manifestations, typical X-ray findings, laboratory tests, and severe underlying neurological disease that can facilitate clinical diagnosis. The management goal for CN patients is early diagnosis and intervention to maintain joint and limb function and active treatment of primary underlying diseases. The surgical strategy for CN of the hip remains controversial.

1.1 仪器 LC-20A HPLC(日本岛津公司)；AB SCTEX QTRAP 5500 串联质谱(美国AB公司)；T25 D高速匀浆机(德国IKA公司)；MS3 D S25涡旋混合仪(德国IKA公司)；BSA224S - CW 万分之一电子天平(德国 Sartorius公司)；LDZS - 2 高速离心机(北京京立离心机公司)；0.22 μm 有机系微孔滤膜(北京科瑞海科学仪器有限公司)。

We thank the staff at the Department of Radiology and the Department of Pathology in Yunnan Provincial Hospital of Traditional Chinese Medicine.

冰层与闸门牢固结冻后，当气温升高时，闸门将受到静冰压力影响；当水位升降时，冰层会产生上抬力或下拉力，特别是两种力同时反复发生时，将导致闸门产生变形，闸墩产生裂缝。每当冬季来临，我国北方寒冷地区的水库都存在冰压力对闸门产生破坏的现象。所以必须采取防冰措施，以尽量避免和减少闸门前的冰压力，确保闸门安全越冬。