柯萨奇病毒A组6型所致手足口病的临床特征分析

任小梅

[關键词] 手足口病;柯萨奇病毒;临床特征;特征分析

[中图分类号] R725.1          [文献标识码] B          [文章编号] 1673-9701（2021）19-0156-04

Clinical characteristics analysis of hand，foot and mouth disease caused by coxsackievirus group A type 6

REN Xiaomei

Department of Infectious Diseases，Tai'an Maternal and Child Health Hospital，Tai'an   271000，China

[Abstract] Objective To understand the clinical features of coxsackievirus A6 （CV-A6）-associated hand， foot， and mouth disease （HFMD），to explore the clinical features of HFMD caused by different enteroviruses，and to provide a scientific basis for future HFMD prevention and control strategies. Methods The information on cases of CV-A6 HFMD diagnosed in the Department of Infectious Diseases of our hospital from 2018 to 2019 was collected by retrospective investigation and research method. According to different ages，the patients were divided into the infant group，preschool group，and school age group. The clinical characteristics and auxiliary examinations of the 3 groups were analyzed and compared. Results In the statistically significant differences in exudation clinical manifestations of the three groups，84.86% of the children were accompanied by fever. The incidence of fever，multi-site rash，and polymorphic rash in the infant group were higher than those in the preschool and school-age groups. The difference in polymorphic rash among the three groups was statistically significant （χ2=7.316， P=0.026）. The school-age group was prone to have digestive associated symptoms. The preschool group was prone to have respiratory associated system. The infant group was prone to have clinical manifestations of nervous system involvement. The onychomadesis rate of this group was slightly higher than that of the preschool group and the school age group. The differences in respiratory symptoms between the two groups were statistically significant （χ2=6.821， P=0.033）. The incidence of elevated white blood cells （38.46%） was the highest in the school-age group. The incidence of elevated CRP （56.90%） was the highest in the preschool-age group. The infant group was prone to have abnormal myocardial enzyme spectrum. And the school-age group was more likely to have an abnormal liver function enzyme spectrum. The 23 cases of chest radiographs with exudation were all infants. The chest radiographs among the three groups showed there were statistically significant differences in exudation （χ2=13.896， P=0.001）. Conclusion The clinical characteristics of CV A6 HFMD are different in different age groups. The infant group is more severely ill than the preschool and school-age groups. In clinical practice，more attention should be paid to the changes in the condition of children in this age group.