同步放化疗与序贯放化疗治疗局部晚期非小细胞肺癌的效果比较

赵强德　汪娇龙　李春燕

[摘要]目的 探讨同步放化疗与序贯放化疗治疗局部晚期非小细胞肺癌（NSCLC）的效果。方法 选取2016年1月～2018年1月我院收治的52例局部晚期NSCLC患者作为研究对象，按照序列分组方法分为对照组（26例）和观察组（26例）。对照组采取序贯放化疗治疗，观察组采取同步放化疗治疗，比较两组的临床疗效及生存质量评分。结果 观察组治疗总有效率为73.07%，高于对照组38.46%，差异有统计学意义（P<0.05）。两组治疗前生存质量评分中的角色、躯体、认知、情绪及社会功能和总健康状况评分比较，差异无统计学意义（P>0.05），观察组治疗后躯体、总健康状况评分高于对照组，差异有统计学意义（P<0.05）。结论 將同步放化疗在局部晚期NSCLC患者的治疗，可显著促进临床治疗效果和患者生存质量的提升，临床应用予以推荐。

[关键词]局部晚期非小细胞肺癌;序贯放化疗;同步放化疗

[中图分类号] R734.2     [文献标识码] A     [文章编号] 1674-4721（2019）9（b）-0057-03

Effect comparison of the concurrent radiotherapy and sequential radiotherapy and chemotherapy in the treatment of locally advanced non-small cell lung cancer

ZHAO Qiang-de   WANG Jiao-long   LI Chun-yan

Department of Oncology， Yingtan People′s Hospital， Jiangxi Province， Yingtan   335000， China

[Abstract] Objective To investigate the effect of concurrent radiotherapy and sequential radiotherapy and chemotherapy in the treatment of locally advanced non-small cell lung cancer （NSCLC）. Methods A total of 52 patients with locally advanced NSCLC admitted to our hospital from January 2016 to January 2018 were selected as the study subjects. They were divided into control group （26 cases） and observation group （26 cases） according to the sequence. The control group was treated with sequential radiotherapy and chemotherapy， while the observation group was treated with concurrent radiotherapy and chemotherapy. The clinical efficacy and quality of life score of the two groups were compared. Results The total effective rate of treatment in the observation group was 73.07%， higher than that in the control group （38.46%）， with statistical difference （P<0.05）. There was no statistical difference in the role， body， cognition， emotion， social function and total health status between the two groups before treatment （P>0.05）. After treatment， the indexes of body and total health status in the observation group were higher than those in the control group， with statistical difference （P<0.05）. Conclusion Concurrent chemoradiotherapy in the treatment of locally advanced NSCLC patients can significantly improve the clinical efficacy and quality of life of patients， therefore， clinical application is recommended.

[Key words] Locally advanced non-small cell lung cancer; Sequential radiotherapy and chemotherapy; Concurrent radiotherapy and chemotherapy

现阶段，受人口老龄化加剧和工业化进程加速的影响，肺癌患者也呈现出增长之势[1]。相比较健壮的青年人而言，老年人的身体免疫机能减弱，同时还合并其他多种基础代谢性疾病，成为肺癌的易感人群。而在肺癌患者中，约有7成以上为局部晚期非小细胞肺癌（NSCLC）[2]。局部晚期NSCLC患者在发现时多错过了最佳的手术治疗时机，临床多采取放化疗进行治疗。采取放化疗对局部晚期NSCLC患者治疗，可以减轻患者痛苦，提高整体疗效。为探讨同步放化疗和序贯放化疗在局部晚期NSCLC患者治疗中的治疗价值，本研究特调查我院接受治疗的52例局部晚期NSCLC患者，现报道如下。