Review for treatment and signaling pathway regulation of kidney-tonifying traditional Chinese medicine on osteoporosis

Ya-ping XIAO,Jie ZENG,Lin-na JIAO,Xiao-yu XU

（1.College of Pharmaceutical Sciences&Chinese Medicine,Southwest University,Chongqing 400715,China;2.Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine,Chongqing 400715,China;3.Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine,Chongqing 400715,China）

T2-28

Review for treatment and signaling pathway regulation of kidney-tonifying traditional Chinese medicine on osteoporosis

Ya-ping XIAO1,2,3,Jie ZENG1,2,3,Lin-na JIAO1,2,3,Xiao-yu XU1,2,3

（1.College of Pharmaceutical Sciences&Chinese Medicine,Southwest University,Chongqing 400715,China;2.Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine,Chongqing 400715,China;3.Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine,Chongqing 400715,China）

The treatment and signaling pathway regulation effects of kidney-tonifying traditional Chinese medicine on osteoporosis have been widely studied,but without a systematic summary currently.This review comprehensively collected and analyzed the traditional Chinese medicine on the treatment and signaling pathway regulation of osteoporosis in recent ten years,such as Epimedium,Drynariae Rhizoma,Cnidium,Eucommia,Psoralen and Dipsacus.Based on the existing findings,we concluded the following conclusions:(1)kidney-tonifying traditional Chinese medicine treats osteoporosis mainly through BMP-Smads,Wnt/β-catenin,MAPK,PI3K/AKT signaling pathway to promote osteoblast bone formation and through OPG/RANKL/RANK,estrogen,CTSK signaling pathway to inhibit osteo⁃clasts of bone resorption.①Epimedium,Drynariae Rhizoma,Cnidium and Psoralen up-regulate the key proteins and genes of BMP-Smads and Wnt/β-catenin signaling pathways to promote bone formation.②Epimedium,Drynariae Rhizoma,Cnidium,Eucommia,Psoralen,Dipsacusinhibit the bone resorption by mediating the OPG/RANKL/RANK signaling pathway.(2)Kidney-tonifying traditional Chinese medicine prevent and treat osteoporosis through a variety of ways:Icariin,Naringin,Osthol,Psoralen can regulate BMP-Smads,Wnt/β-catenin signaling pathway to promote bone formation,but also activate OPG/RANKL/RANK,CTSK and other signaling pathway to inhibit bone resorption.(3)The crosstalk of the signaling pathways and the animal experiments of the traditional Chinese medicine on the prevention and treatment of osteoporosis as well as their multi-target mechanism and comprehensive regulation need further clarification.

kidney-tonifying traditional Chinese medicine;osteoporosis;signaling pathways;bone metabolism;osteoblast;osteoclast