Cellular and molecular perspectives of macrophage in rheumatoid arthritis

Xin-ming WANG,Wei WEI

(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei 230032,China）

T1-35

Cellular and molecular perspectives of macrophage in rheumatoid arthritis

Xin-ming WANG,Wei WEI

(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei 230032,China）

Rheumatoid arthritis(RA)is a systemic,inflammatory autoimmune disease,which is still a significant unmet medical need despite significant therapeutic advances.The pathogenesis of RA involves many types of immune cells,such as T cells,B cells,macrophages and so on.It′s known that the synovial membrane contains two layers,the outer layer,or subintima and the inner layer,or intima.The intimal cells mainly include two types of cells,fibroblasts synoviocyte and macrophage-like synoviocyte.In the inflamed rheumatoid synovial tissues,there is a large number of macrophage-like synoviocytes.These cells can produce key pro-inflammatory cytokines,chemokines and growth factors and their signaling pathways,including nuclear factor κB,Janus kinase-signal transducer,are highly activated.It will trigger cartilage destruction and perpetuate inflammation.This review attempts to high⁃light some aberrations of macrophage in immunoreaction including the roles of genetic and environ⁃mental factors,cellular alterations,especially signaling pathways that are implicated in the pathogenesis of RA.

cell;molecular;perspectives;macrophage;rheumatoid arthritis

The project supported by National Natural Science Foundation of China(81330081,81473223 and 81673444)

Wei WEI,Tel:13605510563,E-mail：wwei@ahmu.edu.cn