Research progress of TREM2 in Alzheimer disease

Yu-bao CHEN,Xiao-yu XU

(College of Pharmaceutical Sciences&Chinese Medicine,Southwest University,Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine,Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine,Chongqing 400715,China)

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Research progress of TREM2 in Alzheimer disease

Yu-bao CHEN,Xiao-yu XU

(College of Pharmaceutical Sciences&Chinese Medicine,Southwest University,Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine,Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine,Chongqing 400715,China)

Alzheimer disease(AD)is a common neurodegenerative disease in the elderly,but nowadays the pathogenesis of AD is unclear.Myeloid cell 2 trigger receptor(TREM2)is one of the most famous and most common rare mutations in neurodegenerative disease research,and its functional site mutation can significantly increase the incidence of AD.In this paper,we summary the structure,localization,and function and related signaling pathways of TREM2,review the latest epide⁃miological findings of TREM2 associated with the pathogenesis of AD,and speculate on the possible role of TREM2 in the progression of this disease,as well as the expression of TREM2 and the role of soluble TREM2 in AD brain are further elucidated.Based on the potential protective effect of TREM2 in the pathogenesis of AD,Therefore,targeting TREM2 may provide new opportunities and a reference for AD treatment.As the TREM2 variant appears to be widely involved in neurodegenerative diseases,there is an urgent need to further study the function of TREM2 in the brain and to find its ligands involved in TREM2-mediated signaling transduction and its specific role in AD pathogenesis.

Alzheimer disease；TREM2；Aβ；genetics；inflammation；phagocytosis

The project supported by National Natural Science Foundation of China(81473549)

Yu-bao CHEN，E-mail:cyb1116@email.swu.edu.cn