“易损斑块无创、高分辨超声功能与分子定量成像”研究2010年度报告

万明习　宗瑜瑾　万锦锦　吴道澄　谷晓林

摘要：本研究本年度在（1）高分辨超声成像理论与方法、（2）微泡制备、高CTR造影成像及灌注参量成像、（3）血管及其周围组织运动与弹性检测成像、（4）超声空化机理等四个方面研究取得重要进展。对高帧率、较高频率超声图像分别进行了基于光流场（OF）的IBP超分辨重建和基于灰度非均匀校正的超分辨重建，重建后轴向及横向分辨率可达到原始图像的4倍以上；并在低成本数字超声成像系统上实现了高CTR值的造影成像和灌注参量定量成像和脉冲逆转小波变换造影成像技术；初步得到模仿人体生理pH环境下，聚焦超声自由空化场中声致发光（SL）的光学检测实验结果及声致化学发光（SCL）的光学检测实验结果。

关键词：超分辨重建；超声造影成像；超声空化；声致发光；

Abstract：This year we make important progresses in following aspects： （1） Principle and methods of high resolution ultrasound imaging， （2）Preparation of microbubbles， ultrasound perfusion imaging with high CTR and perfusion parameter imaging， （3）motion and elasticity imaging of vascular and surrounding tissue， （4）mechanism of ultrasound cavition. The high frame rate and higher frequency ultrasound images have been made IBP super-resolution reconstruction based on optic flow and super-resolution reconstruction based on grey scale ununiformity correction， and the axial and lateral resolution after reconstruction can reach to four times higher than the original images. Additionally， ultrasound contrast imaging with high CTR， perfusion parameter quantitative imaging and pulse inverse wavelet transform contrast imaging have been realized on low cost digital ultrasound imaging system. Preliminary optical experimental results of sonoluminesence （SL） and sonochemoluminesence （SCL） in focused ultrasound free cavitation field have been obtained in a pH similar to human physiological environment.

Keywords：super-resolution reconstruction；ultrasound perfusion imaging；ultrasound cavitation；sonoluminesence