第1期
研究报告
七甲川菁染料与醋酸阿比特龙的化合物应用于小鼠前列腺癌的活体成像和治疗研究
谭邓旭,马帅军,吴朋朋,等(1)
BMSCs过表达BMP-4复合同种异体骨修复软骨缺损
张 飞,温福利,党 源,等(7)
自发性先天性白内障大鼠皮肤移植及生化位点的研究
尤金炜,董 敏,吴正林,等(13)
孕期营养补充剂对妊娠母鼠和仔鼠行为学影响
张长勇,白兢毳,暴 国,等(17)
miRNA-125a靶向调控Bcl-2对癫痫大鼠神经元凋亡的影响
裴 静,陈 明,高 华,等(23)
应用COMT基因SNP位点鉴别拉布拉多和金毛猎犬胆量行为的研究
白 静,马雪娜,陈舒婷,等(29)
HEV经输血感染兔模型研究
梁春南,刘志国,黄维金(35)
研究简报
国内外不同体制下实验动物管理政策体系和标准体系的分析与启示
巩 薇,卢胜明,陈洪岩,等(43)
新媒体环境下实验动物科普传播模式的探析
李会萍,王晓明,杨锦淳,等(49)
实验动物设施废气处理设备工艺选择
刁瑞国,张文明,李 娜(53)
一种改良的兔经胃给药方法
李彦锦,蔡贤华,丰瑞兵,等(56)
SPF小鼠上呼吸道常见细菌的分离鉴定及携带率分析
魏天文,胡芹宝,宣俊文,等(59)
研究进展
妊娠糖尿病大鼠造模方法研究进展
江心泳,葛 莉,庞书勤,等(63)
禽源沙门氏菌快速检测方法研究进展
方焕新,李智丽,黄淑坚,等(69)
遗传修饰小鼠模型基因型鉴定技术要点介绍
刘甦苏,王辰飞,岳秉飞,等(74)
第2期
研究报告
二母散对博来霉素诱导大鼠肺纤维化模型FGF、CTGF和Collagen Ⅰ表达的影响
李 想,刘 畅(1)
干扰长链非编码RNA NEAT1上调miR-126抑制胃癌细胞的生长、间质转换及裸鼠肿瘤形成
陶正贵,杜静虎,田 葵,等(8)
补肾清肝疏脾法对2型糖尿病SD大鼠模型肠道菌群改善及MAPK信号通路的影响
范艳艳,陈 晟,邢 俊,等(17)
间充质干细胞移植改善脑室周围白质软化损伤作用的研究
巴依尔才次克,王彦梅,朱艳萍(22)
基于液质联用技术对早期高脂血症金黄地鼠肝脏鞘脂的靶向代谢组学研究
孙明谦,苗 兰,张 颖,等(30)
氢气对实验性小鼠过敏性鼻炎减轻作用的研究
严伟明,龙 盘,杨健松,等(35)
脑蛋白水解液对七氟醚麻醉导致的大鼠学习记忆障碍的影响
童 华,王欣路,冉志超,等(42)
正交试验设计探索小鼠不同组织冰冻切片的优化制备方法
房彬彬,孙 立,刘 芬,等(48)
DRD1基因敲除影响雄鼠生育的分子机理研究
龚晓娟,马 盼,孙 敏,等(53)
研究简报
常规动物麻醉药作用于雄性小鼠不同时间血液指标变化的分析
刘 燕,彭薪元,丁 洁,等(57)
推进我国实验动物福利技术的研究和应用
刘晓宇,卢选成,鹿双双,等(61)
实验动物设施的噪声不确定度评定
刘 巍,侯丰田, 梁春南(67)
研究进展
挫伤型脊髓损伤动物模型制作方法研究进展
姬笑颜,李含笑,刘西纺(70)
咳嗽变异性哮喘病理机制及造模方法的研究进展
陈婷婷,易桂生(74)
第3期
研究报告
二乙基亚硝胺诱导小鼠肝纤维化动态模型的建立及病理机制初探
王明亮,彭蕴茹(1)
CD40免疫检查点人源化小鼠的制备及在抗体药物研究中的应用
张 静,张 赞,赵 磊,等(10)
耐辐射奇球菌急性毒性研究
许 琴,宋来阳,张 蕾,等(17)
CB6F1-Tg(HRAS)Nifdc小鼠与CByB6F1-Tg(HRAS)2Jic小鼠的脏器及血液生理指标测定与比较分析
刘甦苏,魏 杰,王辰飞,等(23)
黄芪甲苷对糖尿病性白内障SD大鼠晶状体组织的MDA、SOD及GSH-Px水平的影响研究
解艳艳,孙雅彬(29)
氢吗啡酮对炎性痛大鼠脊髓ERK1/2信号通路的影响
石晓玲,贾 伟(34)
四氯化碳致大鼠肝纤维化动物模型的文献再评价
李高辉,吕文良,闫 暾,等(39)
不同干预方式对ASD大鼠认知能力的影响及机制探讨
魏渼淇,刘忠民,冯广智(47)
基于VB的实验动物环境设施参数快速计算器开发与应用初探
刘 巍,赵明海,侯丰田,等(54)
研究简报
SD大鼠凝血四项检查正常参考值范围探讨
刘珍清,赵媛媛,任一冉,等(59)
大鼠脑缺血再灌注模型制作流程详述及经验总结
吴 琳,吴 芳,刘娅楠,等(62)
巴马小型猪胰腺解剖学特点
赵玉琼,戴 鑫,陈 华(66)
单操作者大鼠腹腔异位心脏移植模型的建立与改良
曾 顺,刘达兴(70)
研究进展
实验动物病理学检测与实施成果
赖梦雨,周向梅,赵德明,等(75)
椎间盘退变动物模型的研究进展
张欣怡,杨艳妮,姬笑颜,等(79)
第4期
专家论坛
实验动物遗传质量监测技术研究进展与应用
杜小燕,霍学云,陈振文(1)
病理学在人类疾病实验动物模型评价中的作用和意义
杨利峰,赵德明(6)
研究报告
137Cs-γ辐照对实验红鲫的组织病理学影响
陶宏婷,廖小立,彭赞平,等(11)
心肌细胞条件性Ppara敲除小鼠模型中他莫昔芬安全有效剂量的筛选
王晶晶,池亚菲,乔 欣,等(16)
自建Tg.C57-rasV1.0小鼠模型与日本Tg.rasH2小鼠遗传学及其杂交1代生物学特性比较
刘甦苏,曹 愿,杨艳伟,等(22)
R26-hSCARB2小鼠生理生化指标的测定与分析
周佳琪,魏 杰,王 洪,等(28)
血管内皮生长因子结合可降解壳聚糖治疗大鼠心肌梗塞的研究
李延民,冯 艳,魏燕云,等(33)
MAOA在诱导前列腺癌神经内分泌分化中的作用
税 雪,许 荣,谢清华,等(40)
研究简报
阿尔茨海默症基因修饰小鼠模型
李志萍,杨利峰,周向梅,等(47)
基于物联网及大数据技术的实验动物中心运营管理实践
李自发,耿希文,徐凯勇,等(52)
三种重组乙型肝炎疫苗异常毒性检查对动物影响的比较
曹春然,刘洪艳,李雪梅,等(56)
猪肠系膜上动脉血栓模型建立的改良方法
丛铭池,荆玉辰,辛世杰(62)
亚硝酸异丁酯遗传毒性效应的研究
赵少浩,章跃龙,蒋清清,等 (65)
研究进展
猕猴结肠镜检查前的肠道准备
唐川君,龚 慧,黄志寅,等(69)
老年慢性创面动物模型的建立及研究进展
徐 烽,樊炜静,张寅峰,等(73)
慢性支气管炎动物模型的研究进展
崔 爽,张明倩,梁五林,等(78)
第5期
专家论坛
通过制度建设推进我国实验动物福利伦理审查工作
刘晓宇,贺争鸣(1)
论著
热应激对ICR雌性小鼠超数排卵及卵泡发育的影响
田永路,李 娜,田 祯,等(4)
Caveolin-1在肝纤维化中作用的研究
张 洁,杨子衡,王 燕,等(8)
经皮肺动脉去交感神经冷冻消融术治疗犬肺动脉高压疗效评价
陈 浩,林衔亮,温福利,等(15)
2017—2019 年北京地区实验动物质量抽检结果分析
魏 杰,黄 健,刘文菊,等(19)
高脂饮食对生长期大鼠体质量和骨质量影响的研究
阎国强,刘莉莉,梁 震,等(28)
2017—2019年CD(SD)大鼠240个SNP位点遗传检测结果分析
龙烟朦,郑天威,张巧稚,等(32)
长链非编码RNAH19在多发性骨髓瘤硼替佐米耐药中的作用研究
肖 平,蔡桂程,陈文婷(37)
人参皂苷Rb1干预DSS诱导结肠炎模型小鼠转录组高通量测序及分析
董建一,李昶仪,陈大朋,等(42)
技术
舒泰、速眠新Ⅱ和利多卡因复合麻醉在比格犬开颅手术中的应用
焦 昆,卢 静(49)
姜黄在啮齿类实验动物标认中的应用
矫 建,张婷婷,鹿 麟,等(54)
实验用雪貂的饲养管理探析
何滋林,姚敏桦,韦 涛,等(59)
探讨药物GLP机构中IACUC的职能和伦理审查流程
孙昌华,张艳美,李水仙,等(63)
小鼠电激怒实验中应用研制的智能化电刺激系统提高成模率的探索
王秋静,鲁金凤,于小亚,等(67)
综述
精神分裂症动物模型的研究进展
王凤娟,于小亚,丁 瑜,等(70)
基于CRISPR/Cas9技术构建点突变小鼠概述
刘素丽,朱 云,武会娟(75)
第6期
专家论坛
实验动物行业兽医现状分析
许虎峰,孙晨阳(1)
论著
柚皮苷对DSS诱导结肠炎小鼠肠道菌群的影响
张伟东,徐 阳,郑 路,等(5)
糖氧剥夺对大鼠脂肪干细胞自噬和成脂的影响
袁志坚,吴小瑜,何文涓,等(11)
射干止咳胶囊抗炎作用初探
包玉龙,甘 雨,范英兰,等(16)
miR-143-3p通过调节TGIF2的表达在甲状腺癌中的作用研究
李 佳,李 涛,潘 婧,等(20)
黄甲软肝颗粒对人血白蛋白致免疫性肝纤维化模型大鼠的影响
高晓新,朱春玥,张茜茜,等(28)
两种国产与一种进口小鼠肝炎病毒ELISA抗体检测试剂盒的比较研究
方 姣,梁锦宁,方 茜,等(33)
妊娠SD大鼠血糖指标值的系统评价和单组连续变量Meta分析
江心泳,葛 莉,赖玉婷,等(37)
SPF级SD与Wistar大鼠不同饲养周期和性别部分生物学指标的比较分析
泰 刚,郭 东,杨志敏,等(47)
牛蛙替代蟾蜍在生理教学实验中的应用研究
徐彩云,李天舒,李晓慧,等(53)
慢性心力衰竭兔心室结构重构对心电生理功能产生的影响及意义
安晓霞,贺梅年,何秀英(59)
技术
实验动物病理组织切片质量评价体系与回顾性分析
乔 欣,李 梦,焦 昆,等 (63)
实验牛微生物学和寄生虫学等级及监测地方标准的研究和制定
李昌文,朱远茂,夏长友,等(66)
中央排风通气笼具(EVC)和独立通气笼具(IVC)的技术指标和参数评价
耿祥飞,王 鹏,刘鹏杰,等(73)
基因工程小鼠剖宫产生物净化技术的研究
张 曼,彭丽娜,高则发,等(76)
综述
实验用猫的应用及标准化
陈 军,王 亮,邱泽文,等(80)
LABORATORYANIMALSCIENCEVolume38Number1—62021CONTENTSINBRIEF
Number1
Application of Near-infrared Fluorescent Dyes and Abiraterone Compounds for Living Imaging and Treatment of Prostate Cancer
TAN Dengxu, MA Shuaijun, WU Pengpeng,etal(6)
Repairment of Cartilage Defects through BMSCs Overexpression BMP-4 with Allogeneic Bone
ZHANG Fei, WEN Fuli, DANG Yuan,etal(12)
Research of Skin Transplantation and Biochemical Marker Genes in Spontaneous Congenital Cataract Rats
YOU Jinwei, DONG Min, WU Zhenglin,etal(16)
Effect of Nutritional Supplements during Pregnancy on Spontaneous Motor Activity and Explorative Behavior of Mother and Filial Mice
ZHANG Changyong, BAI Jingcui, BAO Guo,etal(22)
Effect of miRNA-125a Targeted Regulation ofBcl-2 on Neuronal Apoptosis in Epileptic Rats
PEI Jing, CHEN Ming, GAO Hua,etal(28)
Study on the Application of COMT Gene SNP Loci in the Identification of the Timid Temperament of Labrador and Golden Retriever
BAI Jing, MA Xuena, CHEN Shuting,etal(34)
Study on Rabbit Model of Hepatitis E Virus Infection by Blood Transfusion
LIANG Chunnan, LIU Zhiguo, HUANG Weijin,etal(42)
Analysis and Enlightenment of Policy System and Standard System of Laboratory Animal Management under Different Systems at Home and Abroad
GONG Wei, LU Shengming, CHEN Hongyan,etal(48)
Dissemination Mode Research on Science Popularization of Laboratory Animals in the New Media Environment
LI Huiping, WANG Xiaoming, YANG Jinchun,etal(52)
Technological Process of Waste Gas Treatment Equipment for Laboratory Animal Facilities
DIAO Ruiguo, ZHANG Wenming, LI Na(55)
A Modified Method for the Transgastric Administration of Rabbit
LI Yanjin, CAI Xianhua, FENG Ruibing,etal(58)
Analysis of Carrying Status in Common Bacteria Identified from the Upper Respiratory Tract of SPF Mice
WEI Tianwen, HU Qinbao, XUAN Junwen,etal(62)
Research Progress on Modeling Methods in Gestational Diabetes Rats
JIANG Xinyong, GE Li, PANG Shuqin,etal(68)
Review on Rapid Detecting Approaches of Avian Salmonella
FANG Huanxin, LI Zhili, HUANG Shujian,etal(73)
The Key Points of Genotype Identification in Genetically Modified Mice Model
LIU Susu, WANG Chenfei, YUE Bingfei,etal(78)
Number2
Effect of Ermu Powder on the Expression of FGF, CTGF and Collagen Ⅰ in Rat Pulmonary Fibrosis Model Induced by Bleomycin
LI Xiang, LIU Chang(7)
Interfering Long-chain Non-coding RNA NEAT1 Up-regulation of miR-126 in the Inhibition of Gastric Cancer Cells Growth, Epithelial-mesenchymal Transition and Tumor Formation in Nude Mice
TAO Zhenggui, DU Jinghu, TIAN Kui,etal(16)
Effect of Bushen Qinggan Shupi on Intestinal Flora Improvement and MAPK Signaling Pathway in Type 2 Diabetes Model Rats
FAN Yanyan, CHEN Cheng, XING Jun,etal(21)
Study on the Effect of Mesenchymal Stem Cell Transplantation on Softening Damage of Periventricular White Matter
BA Yiercaicike, WANG Yanmei, ZHU Yanping(29)
Targeted Metabonomics of Sphingolipids in Liver Tissue from Early Stage Hyperlipidemia Hamsters Using Liquid Chromatography-tandem Mass Spectrometry
SUN Mingqian, MIAO Lan, ZHANG Ying,etal(40)
Research on the Alleviating Effect of Hydrogen Gas on Allergic Rhinitis in Mice
YAN Weiming, LONG Pan, YANG Jiansong,etal(41)
Effect of Cerebroprotein Hydrolysate Injection on Learning and Memory Impairment Caused by Sevoflurane Anesthesia in Rats
TONG Hua, WANG Xinlu, RAN Zhichao,etal(47)
Improvement of the Preparation Method of Frozen Sections for Different Tissues of Mice by Orthogonal Design
FANG Binbin, SUN Li, LIU Fen,etal(52)
Study on Molecular Mechanism of Male Mice Reproduction inDRD1 Knockout
GONG Xiaojuan, MA Pan, SUN Min,etal(60)
Analysis of the Changes of Blood Indicators of Male Mice by Conventional Animal Anesthetics at Different Times
LIU Yan, PENG Xinyuan, DING Jie,etal(60)
To Advance the Development of Laboratory Animal Welfare Technology in China
LIU Xiaoyu, LU Xuancheng, LU Shuangshuang,etal(66)
Evaluation of Uncertainty in Noise Measurement for Laboratory Animal Housing Facilities
LIU Wei, HOU Fengtian, LIANG Chunnan(69)
Research Progress on Animal Model of Spinal Cord Injury
JI Xiaoyan, LI Hanxiao, LIU Xifang(73)
Research Progress on the Pathological Mechanism and Modeling Methods of Cough Variant Asthma
CHEN Tingting, YI Guisheng(78)
Number3
To Establish a Dynamic Model of Hepatic Fibrosis Induced by Diethylnitrosamine and Explore its Pathological Mechanism in Mice
WANG Mingliang, PENG Yunru(9)
Establishment of CD40 Immune Checkpoint Humanized Mice and Their Application in Antibody Drug Research
ZHANG Jing, ZHANG Zan, ZHAO Lei,etal(28)
Study on Acute Toxicity ofDeinococcusradiodurans
XU Qin, SONG Laiyang, ZHANG Lei,etal(22)
Comparison of Biological Characteristics of CB6F1-Tg(HRAS)Nifdc Mice and CByB6F1-Tg(HRAS)2Jic Mice
LIU Susu, WEI Jie, WANG Chenfei,etal(28)
Effect of Astragaloside IV on MDA, SOD and GSH-Px Levels in Lens Tissue of SD Rats with Diabetic Cataract
XIE Yanyan, SUN Yabin(33)
Effect of Hydromorphine on ERK1/2 Signal Pathway in Spinal Cord of Rats with Inflammatory Pain
SHI Xiaoling, JIA Wei(38)
Re-evaluation of Literature on Rat Liver Fibrosis Animal Model Induced by Carbon Tetrachloride
LI Gaohui, LV Wenliang, YAN Tun,etal(46)
Effects of Different Interventions on Cognitive Ability in ASD Rats and Possible Mechanisms
WEI Meiqi, LIU Zhongmin, FENG Guangzhi(53)
Development and Application of a Rapid Calculator for Laboratory Animal Facilities Parameters Based on VB
LIU Wei, ZHAO Minghai, HOU Fengtian,etal(58)
Reference Range of Four Tests of Coagulation in the Plasma of SD rats
LIU Zhenqing, ZHAO Yuanyuan, REN Yiran,etal(61)
Detailed Process and Experiences of Cerebral Ischemia-reperfusion Model in Rats
WU Lin, WU Fang, LIU Yanan,etal(65)
Anatomical Characteristics of Pancreas in Bama Minipigs
ZHAO Yuqiong, DAI Xin, CHEN Hua(69)
Establishment and Improvement of Abdominal Heterotopic Heart Transplantation Model in Rats by Single Operator
ZENG Shun, LIU Daxing(74)
Laboratory Animal Pathological Monitoring and Implementation Results
LAI Mengyu, ZHOU Xiangmei, ZHAO Deming,etal(78)
Research Progress in Animal Models of Intervertebral Disc Degeneration
ZHANG Xinyi, YANG Yanni, JI Xiaoyan,etal(83)
Number4
Research Progress and Application of Genetic Quality Detection Technology in Laboratory Animal
DU Xiaoyan, HUO Xueyun, CHEN Zhenwen(5)
The Roles and Significance of Pathology in the Evaluation of Animal Models of Human Diseases
YANG Lifeng, ZHAO Deming(10)
Histopathological Effects of137Cs-γ External Irradiation on Laboratory Red Crucian Carps
TAO Hongting, LIAO Xiaoli, PENG Zanping,etal(15)
Establishment of an Inducible Cardiomyocyte-specificPpara-deficient Mice
WANG Jingjing, CHI Yafei, QIAO Xin,etal(21)
Similarities and Differences between the Self-established Tg.C57-rasV1.0 Transgenic Mice Model and Japanese Tg.rasH2 Mice Model
LIU Susu, CAO Yuan, YANG Yanwei,etal(27)
Determination of Blood Physiological and Serum Biochemical Values ofR26-hSCARB2 Mice
ZHOU Jiaqi, WEI Jie, WANG Hong,etal(32)
Vascular Endothelial Growth Factor Combined with Degradable Chitosan for the Treatment of Myocardial Infarction in Rats
LI Yanmin, FENG Yan, WEI Yanyun,etal(39)
The Function of MAOA in Inducing the Neuroendocrine Differentiation of Prostate Cancer
SHUI Xue, XU Rong, XIE Qinghua,etal(46)
Genetic Modified Mouse Models of Alzheimer’s Disease
LI Zhiping, YANG Lifeng, ZHOU Xiangmei,etal(51)
Operation and Management Practice of Laboratory Animal Center Based on Internet of Things and Big Data Technology
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Improved Method for Establishment of Porcine Superior Mesenteric Artery Thrombosis Model
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Bowel Preparation before Colonoscopy on Macaques
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Number5
Promotion of the Ethical Review of Laboratory Animal Welfare through Institutional Construction
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Effects of Heat Stress on Superovulation and Follicular Development in the Female Mice
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Study on the Role of Caveolin-1 in Liver Fibrosis
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Analysis of Random Testing Results of Laboratory Animals in Beijing Area from 2017 to 2019
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Effects of High-fat Diet on Body Weight and Bone Mass of Growth Period Rats
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The 240 SNPs Panel Genetic Monitoring Analysis of CD (SD) Rats from 2017 to 2019
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The Role of Long-chain Non-codingRNAH19 in Bortezomib-resisted Multiple Myeloma
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Number6
Veterinary Status of Laboratory Animal Industry
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The Effect of Naringin on the Intestinal Flora of DSS-induced Colitis Mice
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Comparison of Two Domestic and One Imported ELISA Kits for the Detection of Mouse Hepatitis Virus Antibodies
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Normal Reference Ranges of Blood Glucose Indexes among Pregnant SD Rats: A Systematic Review and Meta-analysis in Single Group Continuous Variables
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Study on the Application of Bullfrog Instead of Toad in Physiology Teaching Experiment
XU Caiyun, LI Tianshu, LI Xiaohui,etal(58)
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AN Xiaoxia, HE Meinian, HE Xiuying(62)
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Stability Evaluation about Technical Parameters of EVC and IVC Systems
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Application and Standardization of Laboratory Cats
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