去氧孕烯炔雌醇片与甲羟孕酮治疗青春期功能失调性子宫出血的临床效果对比

刘志华

[摘要]目的 探討去氧孕烯炔雌醇片与甲羟孕酮治疗青春期功能失调性子宫出血的临床效果，为临床治疗药物选择提供科学依据。方法 选择2015年3月～2017年3月在我院采用甲羟孕酮治疗的青春期功能失调性子宫出血患者52例作为本次研究对照组，另取同期在我院采用去氧孕烯炔雌醇片治疗的52例青春期功能失调性子宫出血患者作为本次研究观察组，将两种不同方法治疗所取得的临床疗效作以比较。结果 观察组总有效率为98.0%明显高于对照组82.7%（χ2=6.172，P<0.05）。与对照组比较，治疗后观察组患者内膜厚度、经期、经量改善效果优势显著（t=3.168，t=32.413，t=11.607，P<0.05）。观察组不良反应发生率为9.6%，明显低于对照组（32.7%）（χ2=17.146，P<0.05）。结论 青春期功能失调性子宫出血采用去氧孕炔雌醇片与甲羟孕酮治疗均能获得一定疗效，但相较之下前者治疗效果更佳，不良反应发生率相对较低，临床应用安全性可靠，非常值得在临床广泛推广应用。

[关键词]去氧孕烯炔雌醇片；甲羟孕酮；青春期功能失调性子宫出血

[中图分类号] R711 [文献标识码] A [文章编号] 1674-4721（2017）11（c）-0081-04

Clinical effect comparison of Desogestrel and Ethlinylestradiol Tablets and Medroxyprogesterone in the treatment of adolescent dysfunctional uterine bleeding

LIU Zhi-hua

Department of Gynaecology，Xiniujiao Community Health Service Station，Jingxi Street，Baiyun District in Guangzhou City of Guangdong Province，Guangzhou 510515，China

[Abstract]Objective To compare the clinical effect of Desogestrel and Ethlinylestradiol Tablets and Medroxyprogesterone in the treatment of adolescent dysfunctional uterine bleeding in order to provide a scientific basis for the drug choice of clinical treatment.Methods From March 2015 to March 2017，52 patients with adolescent dysfunctional uterine bleeding treated by Medroxyprogesterone in our hospital were selected into control group.Meanwhile，52 patients with adolescent dysfunctional uterine bleeding treated by Desogestrel and Ethlinylestradiol Tablets in our hospital were classified into observation group.The clinical effect by the two different methods was compared.Results The total effectiveness rate was 98.0% in the observation group，much higher than that in the control group accounting for 82.7% （χ2=6.172，P<0.05）.Compared with the control group，the improvement of endometrial thickness，menstrual cycle，volume of menses after therapy was all more remarkable （t=3.168，t=32.413，t=11.607；P<0.05）.The incidence of adverse reactions in the observation group was 9.6%，much lower than that in the control group accounting for 32.7% （χ2=17.146，P<0.05）.Conclusion For adolescent dysfunctional uterine bleeding，both Desogestrel and Ethlinylestradiol Tablets and Medroxyprogesterone can obtain a certain effect，and is better in the former which has a lower incidence of adverse reactions and a more reliable safety in clinical application after comparison.Desogestrel and Ethlinylestradiol tablets is worthy to be widely promoted in clinical application.

[Key words]Desogestrel and Ethlinylestradiol Tablets；Medroxyprogesterone；Adolescent dysfunctional uterine bleedingendprint