“聚焦诱导发光的基本科学问题”研究4年报告

董宇平+孙景先+王博+佟斌+张关心

摘 要：该研究通过AIE小分子/高分子的官能化，形成基于AIE原理的化学与生物检测技术，观察到修饰后的AIE分子对蛋白质、酶、DNA、RNA等生物分子的特异响应，实现了深红/近红外荧光的AIE材料在活性细胞与生物体内的应用，同时开展了AIE材料新结构的开发以及应用领域的扩展研究工作。

关键词：聚集诱导发光 化学传感器 生物传感器

Abstract：In this year， we achieved the following progresses：（1）the introduction of the functional groups into AIE compounds；（2）the fabrication of novel AIE system with the mechanochromic properties；（3）the application of AIE compounds for studying the motions of polymeric chains；（4）the application of AIE compounds as biosensors for detection of proteins， enzyme， DNA， RNA and etc.；（5）the application of carmine/NIR AIE compounds for active cells and biosystems. We published 14 peer-reviewed papers and wrote 3 chapters for a Wiley book “Aggregation-Induced Emission”. We gave 3 invited talks on international conference. 4 PhD and 6 MS students graduated.

Key Words：Aggregated-Induced emission； Chemosensors； Biosensors

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