The changing world of drug development

Editorial Offce, Chinese Clinical Oncology, Guangzhou 510120, China

Correspondence to: Grace Li. Editorial Offce, Chinese Clinical Oncology, No. 82 Jiangnandadaozhong Road, Guangzhou 510120, China. Email: editor@thecco.net.

The changing world of drug development

Grace Li

Editorial Offce, Chinese Clinical Oncology, Guangzhou 510120, China

Correspondence to: Grace Li. Editorial Offce, Chinese Clinical Oncology, No. 82 Jiangnandadaozhong Road, Guangzhou 510120, China. Email: editor@thecco.net.

Submitted Apr 02, 2014. Accepted for publication Apr 03, 2014.

View this article at:http://www.thecjcr.org/article/view/3688/4565

Drug development in oncology is undergoing a substantial shift nowadays. The drivers for this are multi-factorial. On the one side, drug development is performed more rationally than ever, profting from the scientifc advances in molecular biology in general and the elucidation of the various "omes" from genome to metabolome in particular. On the other side, it is based on enormous technological progress, e.g., in the feld of genome sequencing, and in that of adequate handling of the resulting plethora of data. The high attrition rate of oncologic drugs under development in the past and the pressure from the side of the payers make it necessary to fnd permanently new answers for and adaptations of the process of drug development. In this context, it is necessary to respect arguments and views from the various perspectives of all the relevant stakeholders.

Together with a group of international experts from different perspectives of drug development, Dr. Christian Dittrich from Center for Oncology and Hematology, Kaiser Franz Josef-Spital, Vienna, Austria, is going to launch a special issue on the Changing World of Drug Development in Chinese Clinical Oncology (CCO) in June 2014.

This special issue will illustrate the respective role of patients, laboratory, clinical trials, drug companies, regulatory bodies, and also the economic principle in drug development, aiming at facilitating drug research in the near future.

The topics to be covered in this special issue are as follows:

❖ Editorial: the Changing World of Drug Development Christian Dittrich; Austria

❖ The Spectrum of Clinical Trials Aiming at Personalizing Medicine Christophe Le Tourneau, Maud Kamal, Maria Alt, Loic Verlingue, Vincent Servois, Marie-Paule Sablin, Nicolas Servant, Xavier Paoletti; France

❖ Drug Designs Fulfilling the Requirements of Clinical Trials Aiming at Personalizing Medicine Sumithra J. Mandrekar, Daniel J. Sargent; USA

❖ Integrative Oncology Drug Discovery Accompanied by Preclinical Translational Research as Prerequisite for Clinical Development Jens Hoffmann; Germany

❖ Translational Research as the Determining Element in the Actual Process of Novel Drug Development Nadia Harbeck; Germany

❖ Functional and Molecular Imaging in Cancer Drug Development Yan Liu; Belgium

❖ Interdisciplinary Challenge of Developing Combined Radio-Drug-Therapies Philippe Maingon; France, Vincent Gregoire; Belgium

❖ An Academic Research Organization's Perspective Yan Liu, Denis Lacombe, Roger Stupp; Belgium

❖ A Global Pharmaceutical Company's Perspective Susan Galbraith; UK

❖ Medicine Adaptive Pathways to Patients (MAPPs): Using Regulatory Innovation to Defeat Eroom's Law Duane Schulthess, Magda Chlebus, Richard Bergström, Karin Van Baelen; Belgium

❖ The Regulatory Bodies' Perspective Iordanis Gravanis, Camille Vleminckx, Bertil Jonsson, Francesco Pignatti; UK

❖ The Positioning of Economic Principles under the Changing Conditions of the Novel Drug Developmental Process in Cancer Nils Wilking, Ulla Wilking, Bengt Jönsson; Sweden

❖ And Now for Something Completely Different: Drugs that work! The Patients' Perspective Peter Kapitein; The Netherlands

Acknowledgements

Disclosure: The author declares no confict of interest.

Cite this article as:Li G. The changing world of drug development. Chin J Cancer Res 2014;26(2):132. doi: 10.3978/ j.issn.1000-9604.2014.04.01

10.3978/j.issn.1000-9604.2014.04.01